Gene interactions and pathways from curated databases and text-mining

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AKT3 — PRKAG1

Text-mined interactions from Literome

Kovacic et al., J Biol Chem 2003 : Because insulin is able to activate Akt and inactivate AMP activated protein kinase (AMPK) in the heart, we hypothesized that Akt can regulate the activity of AMPK ... Taken together, this study suggests that there is cross-talk between the AMPK and Akt pathways and that Akt activation can lead to decreased AMPK activity
Ouchi et al., J Biol Chem 2004 (Neovascularization, Pathologic) : Dominant negative AMPK also inhibited adiponectin induced Akt phosphorylation, suggesting that AMPK is upstream of Akt
Baumann et al., Exp Cell Res 2007 (Multiple Myeloma) : Activation of AMPK inhibited basal extracellular signal regulated kinase ( ERK ), mammalian target of rapamycin (mTOR) and P70S6 kinase ( P70S6K ) as well as AKT phosphorylation, and blocked IL-6, IGF-1, and HS-5 stromal cell conditioned medium induced increase of cell growth
Memmott et al., Cancer Res 2008 (Carcinoma, Non-Small-Cell Lung...) : Here, we show that lipid based Akt inhibitors, phosphatidylinositol ether lipid analogues ( PIA ), activate AMPK independently of LKB1 ... PIAs activated AMPK in LKB1-mutant non-small cell lung cancer ( NSCLC ) cell lines with similar concentration dependence as that required to inhibit Akt ... However, AMPK activation was independent of Akt inhibition
Chan et al., J Biol Chem 2008 (Cardiomegaly) : Taken together, our data suggest that resveratrol exerts anti-hypertrophic effects by activating AMPK via LKB1 and inhibiting Akt , thus suppressing protein synthesis and gene transcription
Youn et al., Circ Res 2009 : These data indicate that AMPK and AKT are both downstream of PI3K and that AKT activation is partially dependent on AMPK
Sag et al., J Immunol 2008 (Inflammation) : In addition, we found that AMPK negatively regulated LPS induced IkappaB-alpha degradation and positively regulated Akt activation, accompanied by inhibition of glycogen synthase kinase beta and activation of CREB
Procopio et al., Endocrinology 2009 : Whether leptin promotes eNOS activation via AMPK dependent activation of Akt , and which of the two AMPKalpha catalytic subunits is involved, remains unknown
Zakikhani et al., Breast Cancer Res Treat 2010 (Breast Neoplasms) : siRNA methods confirmed that reduction of AMPK levels attenuates both the IRS-1 Ser ( 789 ) phosphorylation and the inhibition of AKT activation associated with metformin exposure
Tao et al., Journal of molecular signaling 2010 : Thus, this result suggests that AMPK activation of Akt is not mediated by regulating phosphatase and tensin homologue (PTEN)
Suh et al., Carcinogenesis 2010 (Prostatic Neoplasms) : Fisetin also activated the mTOR repressor TSC2 through inhibition of Akt and activation of AMPK
Memmott et al., Cancer prevention research (Philadelphia, Pa.) 2010 (Carcinoma...) : In lung tissue, metformin did not activate AMPK but inhibited phosphorylation of insulin-like growth factor-I receptor/insulin receptor ( IGF-1R/IR ), Akt , extracellular signal regulated kinase ( ERK ), and mTOR
Leclerc et al., Journal of molecular signaling 2010 : AMPK induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia ... We found that AICAR induced AMPK activation resulted in up-regulation of P-Akt ( Ser473 and Thr308 ) and decrease of P-mTOR ( Ser2448 ) expression and downstream signaling ... We determined that activation of P-Akt ( Thr308 ) was mediated by AMPK induced IGF-1R activation via phosphorylation of the insulin receptor substrate-1 (IRS-1) at Ser794 ... Co-treatment of AICAR plus HNMPA ( AM ) 3 prevented AMPK induced up-regulation of P-Akt ( Thr308 ) but did not alter the activation of P-Akt ( Ser473 ) ... Inhibition of AMPK using compound-C resulted in decreased P-Akt expression at both residues, suggesting a central role for AMPK in Akt activation
Pulinilkunnil et al., J Biol Chem 2011 : Both PKA and AKT inhibitors attenuated AMPK Ser ( 485/491 ) phosphorylation resulting from a-adrenergic blockade and prevented decreases in AMPK activity
Kuznetsov et al., Mol Cancer Ther 2011 (Precursor Cell Lymphoblastic Leukemia-Lymphoma) : Under these conditions, the concomitant inhibition of Akt , a cellular antagonist of AMPK, leads to further upregulation of AMPK activity and alleviates AICAr plus MTX induced ER stress and apoptosis
Carvalho et al., J Clin Endocrinol Metab 2011 (Myocardial Reperfusion Injury...) : However, there was no evidence for AKT dependent AMPK inhibition
Pu et al., J Lipid Res 2011 : Weakening AMPK activity reduced phosphorylation of Akt but not ERK1/2, and Akt inhibitor could not affect ERK1/2 activation either
Tong et al., Mol Carcinog 2012 : Through experiments with over-expression of constitutively active Akt and knockdown of LKB1 expression by siRNAs, we further found that the activation of AMPK by apigenin was not dependent on its inhibition of Akt , and was independent of the activation of upstream kinase LKB1
Priebe et al., Gynecol Oncol 2011 (Ovarian Neoplasms) : Glucose deprivation activates AMPK and induces cell death through modulation of Akt in ovarian cancer cells
Ginion et al., Am J Physiol Heart Circ Physiol 2011 (Insulin Resistance) : In conclusion, although the insulin sensitizing effect of AMPK on PKB/Akt is explained by the inhibition of the insulin induced negative feedback loop, its effect on glucose uptake is independent of this mechanism
Ning et al., Endocrinology 2011 (Diabetes Mellitus, Experimental...) : Suppression of AMPK activation via S485 phosphorylation by IGF-I during hyperglycemia is mediated by AKT activation in vascular smooth muscle cells
Lieberthal et al., American journal of physiology. Renal physiology 2011 : Protection by AMPK appears to be due not to AMPK mediated conservation of cell energy stores, but rather, at least in part, to AMPK mediated activation of Akt
Davila et al., Cell Death Differ 2012 : The activation of AMPK reduced AKT activation, and led to dephosphorylation and nuclear translocation of FOXO3
DeSalvo et al., Mol Cancer Res 2012 (Leukemia, B-Cell...) : In addition, we find that pharmacologic and genetic Akt inhibition upregulates P-AMPK , downregulates UPR, and sensitizes ALL cells to remarkably low doses of 2-DG ( 0.5 mmol/L ), inducing 85 % cell death and overcoming the relative resistance of T-ALL
Liu et al., Biochim Biophys Acta 2012 (Insulin Resistance) : Consistent with this, inhibition of AMPK by compound C induced an enhanced phosphorylation of both S6K1 and Akt , and silencing of S6K1 with siRNA showed no effect on Akt phosphorylation in both the absence and presence of palmitate cultured myotubes
Choi et al., J Cell Physiol 2013 (Neoplasms) : Furthermore, whereas Compound C ( an AMPK inhibitor ), AMPK-DN ( AMPK-dominant negative ) mutant, and SB203580 ( a p38 MAPK inhibitor ) did not block the 8-Cl-cAMP induced phosphorylation of Akt/PKB , TCN ( an Akt1/2/3 specific inhibitor ) and an Akt2/PKBß targeted siRNA inhibited the 8-Cl-cAMP- and AICAR mediated phosphorylation of AMPK and p38 MAPK
Castillo-Pichardo et al., Nutr Cancer 2012 (Breast Neoplasms) : RQC was found to reduce Akt activity, induce the activation of AMPK , and inhibit mTOR signaling in breast cancer cells
Huang et al., Int J Oncol 2013 : In SK-HEP-1 cells, kaempferol increased the protein levels of p-AMPK , LC3-II, Atg 5, Atg 7, Atg 12 and beclin 1 as well as inhibited the protein levels of CDK1, cyclin B, p-AKT and p-mTOR
Suzuki et al., Mol Cell 2013 : Surprisingly, PI3K-Akt signaling, which is a major anabolic signaling and normally inhibits GSK3 activity, promotes GSK3 phosphorylation and inhibition of AMPK , thus revealing how AMPK senses anabolic environments in addition to cellular energy levels