Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
MAPK3
→
PRKD3
(increases, PRKD3 Activity, MAPK3 Activity)
Evidence: we examined the requirement for PKCs in the PMA-induced activation of ERKs by using different PKC inhibitors. Treatment with GF109203X resulted in a total inhibition of ERKs activation, whereas rottlerin had no effect (Figure 8). Because rottlerin is unable to block the activation of ERKs by PMA, PKC-d is not implicated in this process. Given that atypical PKCs were not activated by PMA on the XG-6 cells, these results suggest that PKC-z was not involved...Finally, because XG-6 cells express PKC...