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IL6 — PRL
Text-mined interactions from Literome
Deb et al., Endocrinology 1999
:
Progesterone showed no effect, whereas estradiol and
PRL reduced the level of
IL-6 mRNA expression ... However,
PRL had no effect on
IL-6R mRNA levels ...
PRL inhibition of
IL-6 expression was totally reversed by tyrphostin AG490, a JAK2 inhibitor
Matalka et al., Cytokine 2003
:
Prolactin enhances production of interferon-gamma,
interleukin-12 , and interleukin-10, but not of tumor necrosis factor-alpha, in a stimulus-specific manner
Lee et al., Cancer Res 2005
(MAP Kinase Signaling System) :
To delineate the signaling mechanism from 16-kDa PRL, we examined the
effect of 16-kDa
PRL on
interleukin IL-1beta-inducible iNOS expression, which is regulated by two parallel pathways, one involving IFN regulatory factor 1 (IRF-1) and the other nuclear factor-kappaB (NF-kappaB)
Yang et al., Int Immunopharmacol 2006
:
In addition,
PRL increased the expressions of
IL-6 , IL-10, IL-12 and TNF-alpha in SDCs
Bukulmez et al., BioDrugs 1997
:
In the central nervous system,
interleukin-1 (IL-1) decreases gonadotropin releasing hormone and luteinising hormone levels and
increases prolactin levels
Yamaguchi et al., Endocrinol Jpn 1991
:
The release of
PRL from rat pituitary cells in 30 min was
increased about 2-fold ( p less than 0.05 ) by 10 ( 5 ) U/l interleukin-1 beta, 10 ( 5 ) U/l
interleukin-6 or 100 micrograms/l TNF-alpha
Yamaguchi et al., Acta Endocrinol (Copenh) 1990
:
Interleukin 6 possibly induced by interleukin 1 beta in the pituitary gland
stimulates the release of gonadotropins and
prolactin ... The abilities of recombinant human interleukin 1 (IL-1) and
IL-6 to
induce release of FSH, LH and
PRL from rat pituitary cells in vitro were examined ... IL-1 and
IL-6 induced significant releases of FSH, LH and
PRL within 3 h ... These findings suggest that IL-1 induced the release of IL-6 from rat pituitary, and that the released
IL-6 stimulated the secretions of FSH, LH and
PRL
Spangelo et al., Endocrinology 1989
:
Dopamine ( DA ) attenuated
IL6 induced
PRL release
Jikihara et al., Endocrinology 1994
:
In contrast to the other cytokines,
IL-6 had no effect on basal
PRL release
Tseng et al., Mol Cell Endocrinol 1997
:
Here, we investigated the
effects of GH and
PRL on the expression of interleukin (IL)-1alpha, IL-1beta and
IL-6 in thymic stromal cells (TSC)
Tsigos et al., Neuroendocrinology 1997
:
IL-6 also acutely
stimulated GH and
PRL secretion and suppressed TSH secretion
Telleria et al., Endocrinology 1998
:
Progesterone and dexamethasone markedly inhibited
IL-6 mRNA expression, whereas 17beta-estradiol had a minimal inhibitory effect, and
PRL did not
affect IL-6 mRNA expression
Bellón et al., Int Surg 1998
(Cholelithiasis...) :
Correlation analysis between levels of cytokines and hormones indicated that
prolactin , at concentrations exceeding physiological values,
regulates levels of IL-1 ( p 0.3271, p < 0.05 ) and
IL-6 ( p = 0.3765, p < 0.01 )