Gene interactions and pathways from curated databases and text-mining

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IL6 — PRL

Text-mined interactions from Literome

Deb et al., Endocrinology 1999 : Progesterone showed no effect, whereas estradiol and PRL reduced the level of IL-6 mRNA expression ... However, PRL had no effect on IL-6R mRNA levels ... PRL inhibition of IL-6 expression was totally reversed by tyrphostin AG490, a JAK2 inhibitor
Matalka et al., Cytokine 2003 : Prolactin enhances production of interferon-gamma, interleukin-12 , and interleukin-10, but not of tumor necrosis factor-alpha, in a stimulus-specific manner
Lee et al., Cancer Res 2005 (MAP Kinase Signaling System) : To delineate the signaling mechanism from 16-kDa PRL, we examined the effect of 16-kDa PRL on interleukin IL-1beta-inducible iNOS expression, which is regulated by two parallel pathways, one involving IFN regulatory factor 1 (IRF-1) and the other nuclear factor-kappaB (NF-kappaB)
Yang et al., Int Immunopharmacol 2006 : In addition, PRL increased the expressions of IL-6 , IL-10, IL-12 and TNF-alpha in SDCs
Bukulmez et al., BioDrugs 1997 : In the central nervous system, interleukin-1 (IL-1) decreases gonadotropin releasing hormone and luteinising hormone levels and increases prolactin levels
Yamaguchi et al., Endocrinol Jpn 1991 : The release of PRL from rat pituitary cells in 30 min was increased about 2-fold ( p less than 0.05 ) by 10 ( 5 ) U/l interleukin-1 beta, 10 ( 5 ) U/l interleukin-6 or 100 micrograms/l TNF-alpha
Yamaguchi et al., Acta Endocrinol (Copenh) 1990 : Interleukin 6 possibly induced by interleukin 1 beta in the pituitary gland stimulates the release of gonadotropins and prolactin ... The abilities of recombinant human interleukin 1 (IL-1) and IL-6 to induce release of FSH, LH and PRL from rat pituitary cells in vitro were examined ... IL-1 and IL-6 induced significant releases of FSH, LH and PRL within 3 h ... These findings suggest that IL-1 induced the release of IL-6 from rat pituitary, and that the released IL-6 stimulated the secretions of FSH, LH and PRL
Spangelo et al., Endocrinology 1989 : Dopamine ( DA ) attenuated IL6 induced PRL release
Jikihara et al., Endocrinology 1994 : In contrast to the other cytokines, IL-6 had no effect on basal PRL release
Tseng et al., Mol Cell Endocrinol 1997 : Here, we investigated the effects of GH and PRL on the expression of interleukin (IL)-1alpha, IL-1beta and IL-6 in thymic stromal cells (TSC)
Tsigos et al., Neuroendocrinology 1997 : IL-6 also acutely stimulated GH and PRL secretion and suppressed TSH secretion
Telleria et al., Endocrinology 1998 : Progesterone and dexamethasone markedly inhibited IL-6 mRNA expression, whereas 17beta-estradiol had a minimal inhibitory effect, and PRL did not affect IL-6 mRNA expression
Bellón et al., Int Surg 1998 (Cholelithiasis...) : Correlation analysis between levels of cytokines and hormones indicated that prolactin , at concentrations exceeding physiological values, regulates levels of IL-1 ( p 0.3271, p < 0.05 ) and IL-6 ( p = 0.3765, p < 0.01 )