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PRL — SRC
Text-mined interactions from Literome
Fresno Vara et al., Mol Biol Cell 2001
:
Because
PRL activates the
Src family of tyrosine kinases (SFK) , we have studied the role of these kinases in PRL cell proliferation signaling
Vulin et al., Endocrinology 2005
:
Expression of dominant negative
Src also
prevented the RPTPalpha mediated inhibition of insulin increased
prolactin gene expression ... Low levels of a constitutively active
Src mutant ( SrcY/F ) stimulated whereas higher expression levels of Src Y/F
inhibited prolactin gene expression
Sakamoto et al., Mol Endocrinol 2007
:
However, Jak2 is dispensable for the
PRL induced activation of
c-Src , focal adhesion kinase, and the MAPK pathway
Liang et al., J Biol Chem 2008
(Neoplasm Metastasis) :
PRL3 induced
Src activation is proposed to be indirect through down-regulation of Csk, a negative regulator of Src ... Given the importance of
PRL3 in tumor metastasis and the
role of Csk in controlling
Src activity, we addressed the mechanism by which PRL3 mediates Csk down-regulation
Aksamitiene et al., Cell Signal 2011
(Breast Neoplasms) :
Quantitative measurements of the phosphorylation/activation patterns of proteins showed that
PRL simultaneously
activated Src family kinases (SFKs) and the JAK/STAT, phosphoinositide-3 (PI3)-kinase/Akt and MAPK signaling pathways
Fiordalisi et al., PloS one 2013
:
Thus,
PRL-3 requires the activity of a Src kinase, likely
Src itself, to promote these cancer associated phenotypes