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NFKB1 — PRNP

Text-mined interactions from Literome

Jana et al., J Immunol 2007 : Involvement of NF-kappaB activation in LPS-, Abeta-, PrP- , poly IC-, Tat-, and MPP+-, but not IFN-gamma-, induced microglial expression of iNOS and stimulation of IkappaBalpha expression and inhibition of NF-kappaB activation by gemfibrozil via the PI3K pathway suggests that gemfibrozil inhibits the activation of NF-kappaB and the expression of proinflammatory molecules in microglia via PI3K mediated up-regulation of IkappaBalpha
Bai et al., Neurosci Res 2008 (Nerve Degeneration...) : For the first time we found that PrP106-126 induced activation of NF-kappaB by Western blot assay, and blocking the interaction of p75 ( NTR ) with PrP106-126 by p75 ( NTR ) polyclonal antibody sc-6189 or pretreatment with inhibitor NF-kappaB SN50 reduced the activation of NF-kappaB and attenuated the apoptotic effect by PrP106-126