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NEUROD6 — PSEN1

Text-mined interactions from Literome

Handler et al., Development 2000 : Presenilin-1 regulates neuronal differentiation during neurogenesis ... These results provide direct evidence that PS1 controls neuronal differentiation in association with the downregulation of Notch signalling during neurogenesis
Uemura et al., J Neurosci Res 2003 : To elucidate the role of presenilin 1-beta-catenin interaction in neuronal differentiation , we established SH-SY5Y cells stably expressing wild-type presenilin 1, P117L mutant presenilin 1, which is linked to the early-onset familial form of Alzheimer 's disease, and D385A mutant presenilin 1, which has no aspartyl proteinase activity
Sarkar et al., J Neurochem 2003 : Regulatory roles of presenilin-1 and nicastrin in neuronal differentiation during in vitro neurogenesis ... Loss of function studies have implicated a role for PS1 in regulating neuronal differentiation in association with the down-regulation of Notch signaling during neurogenesis
Flood et al., Neurochem Int 2004 (Brain Neoplasms...) : These combined observations support the idea that PS1 is involved in neuronal differentiation by a mechanism likely independent of endoproteolysis of the protein
Wines-Samuelson et al., Dev Biol 2005 : Presenilin-1 (PS1) , the major causative gene of familial Alzheimer disease, regulates neuronal differentiation and Notch signaling during early neural development
Gadadhar et al., J Neurosci 2011 : Previous genetic studies using germ-line deletion of PS1 and conditional knock-out mice demonstrated that PS1 plays an essential role in neuronal differentiation during neural development, but it remained unclear whether PS1 plays a similar role in neurogenesis in the adult brain
Busciglio et al., J Neurosci 1997 (Alzheimer Disease) : These results suggest that PS1 is highly expressed and broadly distributed during early stages of neuronal differentiation, consistent with a role for PS1 in neuronal differentiation