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CA2 — PTGS2

Text-mined interactions from Literome

Choudhary et al., J Bone Miner Res 2003 : We conclude that [ Ca2+ ] e is a potent transcriptional inducer of COX-2 expression and PGE2 production in osteoblasts through an ERK signaling pathway
Slice et al., J Biol Chem 2005 : Inhibition of Ca2+ signaling by 2-aminobiphenyl borate blocked Ang II-dependent COX-2 expression ... Luciferase promoter assays showed that Ang II-dependent transcriptional activation of the COX-2 promoter was dependent on activation of small GTPases and p38 ( MAPK ) and on Ca2+ signaling via the cAMP-responsive element/activating transcription factor cis acting element
Katagiri et al., J Bone Miner Res 2006 (Bone Resorption...) : CA II activity was inhibited by sulfonamide-type COX-2 selective agents celecoxib and JTE-522 similarly to a CA II inhibitor acetazolamide, but not by a methylsulfone-type COX-2 inhibitor rofecoxib
Pham et al., J Cell Biochem 2006 : The combined effect of PKC and Ca2+ signaling were prolonged COX-2 and mPGES-1 mRNA and protein expression ... Inhibition of PKC activity, MEK activity, or Ca2+ signaling blocked agonist induction of COX-2 and mPGES-1
Ogata et al., Biochem Biophys Res Commun 2006 (Calcium Signaling) : Ca2+ stimulates COX-2 expression through calcium sensing receptor in fibroblasts