Gene interactions and pathways from curated databases and text-mining

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IL6 — PTGS2

Text-mined interactions from Literome

Vallières et al., Endocrinology 1999 (Endotoxemia) : The fact that IL-6 alone or injected after LPS treatment was unable to induce cyclooxygenase-2 synthesis is an argument in favor of a PG-independent mechanism
Akarasereenont et al., J Med Assoc Thai 1999 (Pre-Eclampsia) : The induction of cyclooxygenase-2 (COX-2) in cultured endothelial cells treated with serum from preeclampsia is mediated by interleukin-6 ... Thus, the induction of COX-2 in pSerum treated nHUVEC was mediated by IL-6
Yamamoto et al., FEBS Lett 2000 (Bone Resorption) : Reporter gene experiments suggested that humulon blocked the cyclooxygenase-2 expression mediated by NFkappaB and NF-IL6 , but the intracellular glucocorticoid receptor was not involved
Fosslien et al., Ann Clin Lab Sci 2000 (Carcinoma, Squamous Cell...) : COX-2 is inducible by oncogenes ras and scr, interleukin-1 , hypoxia, benzo [ a ] pyrene, ultraviolet light, epidermal growth factor, transforming growth factor beta, and tumor necrosis factor alpha ... COX-2 synthesizes prostaglandin E2 ( PGE2 ) which stimulates bcl-2 and inhibits apoptosis, and induces interleukin-6 (IL-6) which enhances haptoglobin synthesis
Inoue et al., Life Sci 2000 : All HMG-CoA reductase inhibitors significantly reduced interleukin-1beta and -6 mRNA expression and their protein levels in the culture medium, and also inhibited cyclooxygenase-2 mRNA expression and their protein levels
Nédélec et al., Biochem Pharmacol 2001 : In monolayers, interleukin-1beta (IL-1beta) induced COX-2 and NOS II expression in a dose- and time dependent manner, to produce high prostaglandin E ( 2 ) ( PGE ( 2 ) ) and nitrite ( NO ( 2 ) ( - ) ) levels in an apparently coordinated fashion
Lahiri et al., Am J Physiol Lung Cell Mol Physiol 2001 : IL-6 , IL-11, and OSM alone had no effect on COX-2 expression
Moore et al., J Appl Physiol 2001 : In human cultured airway smooth muscle cells, interleukin (IL)-1 beta increases cyclooxygenase (COX)-2 expression and PGE ( 2 ) release, ultimately resulting in decreased beta-adrenergic responsiveness
Wang et al., Scand J Gastroenterol 2002 (Carcinoma, Squamous Cell...) : 59 ESCC samples were used to assess COX-2 expression in the tumor cells and four ESCC cell lines to investigate the effects of phorbol myristate acetate ( PMA ), platelet activating factor (PAF), n-sodium butyrate ( n-BT ) and interleukin-6 (IL-6) on the expression of COX-2 ... PKC inhibitor, however, could abrogate PMA induced COX-2 gene expression, but it did not block IL-6 induced COX-2 expression ... Nonetheless, IL-6 induced COX-2 expression could be independent of PKC activation
Basu et al., Glia 2002 (Brain Injuries...) : These studies demonstrated that IL-1beta, TNFalpha, IL-6 , but not IFN-gamma increase the expression of Cox-2 , whereas they all increase the expression of HCK and FAK ... However, TGFbeta1 was ineffective in antagonizing the induction of Cox-2 by either IL-6 or TNFalpha
Dongari-Bagtzoglou et al., Inflamm Res 2003 : CD40 ligation triggers COX-2 expression in endothelial cells : evidence that CD40 mediated IL-6 synthesis is COX-2 dependent ... Moreover, the data strongly suggest that CD154 induced IL-6 secretion in HUVEC is dependent on COX-2 activity
Moon et al., Toxicol Appl Pharmacol 2003 : Cyclooxygenase-2 mediates interleukin-6 upregulation by vomitoxin ( deoxynivalenol ) in vitro and in vivo ... Taken together, these in vitro and in vivo data suggest that VT-induced COX-2 gene expression and resultant COX-2 metabolites contributed , in part, to subsequent upregulation of IL-6 gene expression, which has been previously shown to be a hallmark of VT-mediated immunotoxicity
Soloff et al., Endocrinology 2004 : In situ analysis of interleukin-1 induced transcription of cox-2 and il-8 in cultured human myometrial cells
Bukata et al., J Orthop Res 2004 (Osteolysis...) : Interestingly, COX-2 was also required for IL-6 production in these assays, which could be rescued by the addition of exogenous PGE2 ( 10 ( -6 ) M )
Tipton et al., J Periodontol 2003 (Periodontitis) : The selective COX-2 inhibitors, but not indomethacin, caused partial ( generally up to approximately 60 % ), dose dependent decreases in IL-1beta stimulated IL-6 in all cell lines ( P < or = 0.003 )
Harizi et al., Cell Immunol 2004 : Exogenous IL-10, but not IL-6 , dose-dependently suppresses COX-2 protein expression and PGE ( 2 ) production, and TNF-alpha does not reverse this effect
Stamp et al., J Rheumatol 2004 : Paracrine upregulation of monocyte cyclooxygenase-2 by mediators produced by T lymphocytes : role of interleukin 17 and interferon-gamma
Kagiwada et al., Endocrinology 2004 (Fever) : Cyclooxygenase (Cox)-2 expression in the brain was strongly induced 1.5 h after injection of IL-1alpha, whereas IL-6 expression was observed 3 h after the injection
Park et al., Int J Biochem Cell Biol 2004 (Bone Resorption) : IL-1beta and IL-6 and, to a lesser extent, TNF-alpha, enhances COX-2 mRNA levels in calvarial osteoblasts ... In contrast, the presence of TGF-beta reduced COX-2 mRNA level, PGE ( 2 ) biosynthesis and bone resorption induced by IL-1beta, TNF-alpha, IL-6 or a combination thereof
Dawn et al., Cardiovasc Res 2004 (Myocardial Infarction...) : However, following a PC stimulus, IL-6 is obligatorily required for the activation of the JAK-STAT pathway, the ensuing upregulation of iNOS and COX-2 ( co-mediators of late PC ), and the development of a cardioprotective phenotype
Ha et al., J Leukoc Biol 2005 : Inhibition of cyclooxygenase 2 significantly reduced the PSG17N mediated increase in IL-10 and IL-6
Attar et al., Hum Reprod Update 2006 (Endometriosis...) : COX-2 in turn is stimulated by E ( 2 ), interleukin-1beta (IL-1beta) and PGE ( 2 ) itself in endometrial and endometriotic cells
Jin et al., J Ethnopharmacol 2006 (Bone Resorption...) : IL-1beta and IL-6 and to a lesser extent TNF-alpha, enhanced COX-2 mRNA levels in calvarial osteoblasts ... TGF-beta, YJ ( 100microg/ml ) and their combinations of YJ+TGF-beta reduced the COX-2 mRNA level, PGE2 biosynthesis and bone resorption induced by IL-1beta, TNF-alpha, IL-6 or their combination
Yu et al., Hepatology 2006 (Choline Deficiency...) : In conclusion, induction of COX-2 occurs in association with NF-kappaB activation and upregulation of TNF-alpha, IL-6 , and ICAM-1 in MCD diet induced steatohepatitis
Chen et al., Eur J Pharmacol 2006 : We show that dipyridamole inhibited interleukin-6 and monocyte chemoattractant protein-1 secretion, inducible nitric oxide synthase protein expression, nitrite accumulation, and cyclooxygenase-2 (COX-2) induction in lipopolysaccharide (LPS) activated RAW 264.7 macrophages
Chen et al., J Immunol 2006 : Peptidoglycan induced IL-6 production in RAW 264.7 macrophages is mediated by cyclooxygenase-2 , PGE2/PGE4 receptors, protein kinase A, I kappa B kinase, and NF-kappa B ... PGN mediated IL-6 production was inhibited by a nonselective cyclooxygenase (COX) inhibitor ( indomethacin ), a selective COX-2 inhibitor ( NS398 ), a PGE ( 2 ) ( EP2 ) antagonist ( AH6809 ), a PGE ( 4 ) ( EP4 ) antagonist ( AH23848 ), and a protein kinase A (PKA) inhibitor ( KT5720 ), but not by a nonselective NO synthase inhibitor ( N ( G ) -nitro-l-arginine methyl ester )
Aoki et al., Am J Physiol Cell Physiol 2007 : These data indicate that Smad2/3 dependent pathway plays a central role in COX-2 induction by TGF-beta1, IL-1beta, and IL-6
Sooranna et al., Mol Hum Reprod 2006 : In primary cultures of uterine myocytes, cPLA(2) mRNA expression was increased by IL-1beta and IL-6 ; PGHS-2 mRNA expression was increased by IL-1beta, PGE ( 2 ) and stretch ; and PGES-1 mRNA expression was increased by IL-1beta only
Yu et al., Gut 2007 (Hepatitis, Animal) : Hepatic COX-2 expression in the TG mice resulted in activation of NF-kappaB and inflammatory cytokine cascade, with a marked expression of the proinflammatory cytokines tumour necrosis factor (TNF)-alpha ( 9.4-fold ), interleukin (IL)-6 ( 4.4-fold ), IL-1beta ( 3.6-fold ), and of the anti-inflammatory cytokine IL-10 ( 4.4-fold ) and chemokine macrophage inflammatory protein-2 ( 3.2-fold )
Wu et al., Prostaglandins Other Lipid Mediat 2007 : In this review, we provide evidence for reduced COX-2 transcriptional expression in response to phorbol esters ( PMA ), lipopolysaccharide (LPS), interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha)
Wu et al., Reprod Sci 2007 (Endometriosis) : These results, along with recent findings that TSA suppresses proliferation, interleukin-1 beta induced cyclo-oxygenase 2 expression, and constitutive or TNFalpha stimulated nuclear factor kappa B activation in endometrial and endometriotic cells, makes histone deacetylase inhibitors a promising class of compounds for novel and more effective medical treatment of endometriosis, especially given the mounting evidence that endometrios be an epigenetic disease
L'Eplattenier et al., J Vet Intern Med 2007 (Dog Diseases...) : In addition, a neoplastic and a nonneoplastic canine prostatic cell line were used to investigate the effects of interleukin-6 (IL-6) , tumor necrosis factor-alpha (TNF-alpha), phorbol 12-myristate 13-acetate ( PMA ), epithelial growth factor (EGF), and specific signal transduction pathway inhibitors on COX-2 expression ... In vitro, TNF-alpha, IL-6 , and EGF increased COX-2 expression in nonneoplastic cells but not in PCA cells, where baseline expression was high
Chida et al., Biochem Biophys Res Commun 2007 (Fever) : Only IL-1alpha, but not TNFalpha, induced IL-6 in the IL-1alpha/beta/TNFalpha KO mouse brain, while both cytokines induced cyclooxygenase (Cox)-2
Krady et al., J Neurosci Res 2008 : We show that CNTF reduces COX-2 levels, whereas IL-6 increases the expression of IL-1beta, TNFalpha, and Cox-2
Moon et al., Free Radic Biol Med 2008 : These results show that exogenous NO can increase COX-2 dependent PGD ( 2 ) and IL-6 production by MC in inflammatory environments through the p38 MAPK pathway
Zhao et al., Am J Respir Cell Mol Biol 2009 : In addition, inhibition of COX-2 partly attenuated PM-induced Prostaglandin E2 and IL-6 release
Ara et al., Cancer Res 2009 (Bone Marrow Neoplasms...) : IL-6 induced the expression of cyclooxygenase-2 in neuroblastoma cells with concomitant release of prostaglandin-E2, which increased the expression of IL-6 by BMSC
Chikuma et al., J Mol Neurosci 2009 : These results indicate that interleukin-6/soluble interleukin-6 receptor complexes and the signal transducer 130-kDa glycoprotein play an important role in the regulation of cyclooxygenase-2 expression and subsequent prostaglandin E ( 2 ) formation in mouse astrocytes and that interleukin-6 is an important regulator of immune and inflammatory processes in the CNS
Pagel et al., Bone 2009 : Furthermore, in the presence of the selective cyclooxygenase-1 and -2 inhibitors SC-560 and NS-398 thrombin induced interleukin-6 release was prevented
Nakajima et al., J Neurotrauma 2010 (Inflammation...) : Phosphorylation of STAT3, which is activated by IL-6 , and expression of inducible cyclooxygenase-2 (COX-2) were also compared between the taurine treatment group ( 250 mg/kg ) and the control group by Western blot analysis
Lee et al., Am J Pathol 2010 (Inflammation) : These results demonstrate that LTA induced MAPKs activation is mediated through the TLR2/MyD88/PI3K/Rac1/Akt pathway, which in turn initiates the activation of NF-kappaB, and ultimately induces cPLA(2)/COX-2 dependent PGE ( 2 ) and IL-6 generation
Vinukonda et al., Brain 2010 (Disease Models, Animal...) : Cyclooxygenase-2 or prostanoid receptor-1 inhibition reduced tumour necrosis factor-a level, but not interleukin-1ß
Shah et al., Nat Prod Res 2010 : PBMCs were treated with various concentrations of curcumin, resveratrol and parthenolide and tested for the abilities of these natural products to protect against the LPS induced expression, secretion of the pro-inflammatory cytokines TNFalpha, IL-1beta and IL-6 and activation of the pro-inflammatory COX-2
Gao et al., Toxicol Appl Pharmacol 2010 : IL-6 induced by Ni/MALP-2 co-exposure was partially dependent on activity of HIF-1alpha and COX-2 as shown by targeted knockdown using siRNA
Yoon et al., PloS one 2011 (Graves Disease...) : Quercetin significantly attenuated intercellular adhesion molecule-1 ( ICAM-1 ), interleukin (IL) -6, IL-8, and cyclooxygenase (COX) -2 mRNA expression, and inhibited IL-1ß induced increases in ICAM-1, IL-6 , and IL-8 mRNA
Martín et al., J Hypertens 2012 : This study analyzes the effect of pioglitazone, a PPAR? agonist, on interleukin-1ß induced COX-2 expression and the role of reactive oxygen species ( ROS ) on this effect ... PPAR? activation with pioglitazone reduces interleukin-1ß induced COX-2 expression by interference with the redox-sensitive transcription factor NF-?B
Seo et al., Immunopharmacol Immunotoxicol 2012 (Inflammation) : SPEE treatment significantly inhibited the LPS induced production of NO, prostaglandin E ( 2 ), interleukin-6 , and tumor necrosis factor-a and inhibited the expression of iNOS and COX-2 via attenuation of NF-?B p65 expression
Szczepanski et al., Arthritis Rheum 1994 : Induction of cyclooxygenase II in human synovial microvessel endothelial cells by interleukin-1
Feng et al., Arch Biochem Biophys 1993 : In rat vascular smooth muscle cells, interleukin-1 beta selectively increased the expression of COX-2 , but not that of COX-1, as assessed by enzyme activity, immunoprecipitation of COX proteins, and mRNA analysis
Yamamoto et al., J Biol Chem 1995 : Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha dependent induction of cyclooxygenase-2 in MC3T3-E1 cells ... These data suggested a potential role of both NF-IL6 and NF kappa B in the induction of cyclooxygenase-2 by TNF alpha
O'Banion et al., J Neurochem 1996 : TPA, basic fibroblast growth factor, and the proinflammatory factors tumor necrosis factor alpha and lipopolysaccharide, but not interleukin-6 , also stimulated PGHS-2 mRNA expression
Kawaguchi et al., J Bone Miner Res 1996 (Bone Resorption) : We conclude that ( 1 ) IL-1, TNF-alpha, and PTH, but not IL-6 nor IL-11, can increase the expression of PGHS-2 , cPLA2, and PGE2 production in cultured mouse calvariae ; ( 2 ) IL-4 inhibits PGE2 production in both control and stimulated calvarial cultures by inhibiting PGHS-2 and cPLA2 ; and ( 3 ) IL-4 has an inhibitory effect on bone resorption which is independent of PG production
Arslan et al., Prostaglandins 1996 : In these cells, COX-2 gene expression was inducible by the cytokines interleukin-1 beta and tumor necrosis factor alpha, but not by interleukin-6
Crofford et al., Arthritis Rheum 1997 (Arthritis, Rheumatoid) : Involvement of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes
Tai et al., Endocrinology 1997 : In mouse osteoblastic cells, both IL-1alpha and IL-6 with sIL-6R markedly induced messenger RNA expression of COX-2 , but not COX-1, as determined by Northern blot analysis, and luciferase activity in cells stably transfected with a COX-2 promoter-luciferase fusion construct ... IL-6 and sIL-6R, when added separately, did not stimulate COX-2 messenger RNA expression
Kniss et al., Am J Obstet Gynecol 1997 : Interleukin-1 receptor antagonist blocks interleukin-1 induced expression of cyclooxygenase-2 in endometrium ... Experiments were conducted to examine whether interleukin-1 receptor antagonist could suppress interleukin-1 induced cyclooxygenase-2 expression
Williams et al., J Biol Chem 1997 : The experimental findings demonstrate that the effects of Cox-1 and Cox-2 activity on macrophage IL-6 synthesis are segregated
Ohara et al., Anesthesiology 1998 : Induction of cyclooxygenase-2 in alveolar macrophages after acid aspiration : selective cyclooxygenase-2 blockade reduces interleukin-6 production ... Selective cyclooxygenase-2 blockade reduced production of interleukin-6 by acid stimulated alveolar macrophages
Staels et al., Nature 1998 (Coronary Disease...) : In these smooth-muscle cells, we find that PPARalpha ligands, and not PPARgamma ligands, inhibit interleukin-1 induced production of interleukin-6 and prostaglandin and expression of cyclooxygenase-2
Longo et al., Mediators Inflamm 1998 : The role of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide and interleukin-1 stimulated enterocyte prostanoid formation