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IL6 — PTGS2
Text-mined interactions from Literome
Vallières et al., Endocrinology 1999
(Endotoxemia) :
The fact that
IL-6 alone or injected after LPS treatment was unable to
induce cyclooxygenase-2 synthesis is an argument in favor of a PG-independent mechanism
Akarasereenont et al., J Med Assoc Thai 1999
(Pre-Eclampsia) :
The induction of
cyclooxygenase-2 (COX-2) in cultured endothelial cells treated with serum from preeclampsia is
mediated by
interleukin-6 ... Thus, the induction of
COX-2 in pSerum treated nHUVEC was
mediated by
IL-6
Yamamoto et al., FEBS Lett 2000
(Bone Resorption) :
Reporter gene experiments suggested that humulon blocked the
cyclooxygenase-2 expression
mediated by NFkappaB and
NF-IL6 , but the intracellular glucocorticoid receptor was not involved
Fosslien et al., Ann Clin Lab Sci 2000
(Carcinoma, Squamous Cell...) :
COX-2 is
inducible by oncogenes ras and scr,
interleukin-1 , hypoxia, benzo [ a ] pyrene, ultraviolet light, epidermal growth factor, transforming growth factor beta, and tumor necrosis factor alpha ...
COX-2 synthesizes prostaglandin E2 ( PGE2 ) which stimulates bcl-2 and inhibits apoptosis, and
induces interleukin-6 (IL-6) which enhances haptoglobin synthesis
Inoue et al., Life Sci 2000
:
All HMG-CoA reductase inhibitors significantly reduced
interleukin-1beta and -6 mRNA expression and their protein levels in the culture medium, and also
inhibited cyclooxygenase-2 mRNA expression and their protein levels
Nédélec et al., Biochem Pharmacol 2001
:
In monolayers,
interleukin-1beta (IL-1beta)
induced COX-2 and NOS II expression in a dose- and time dependent manner, to produce high prostaglandin E ( 2 ) ( PGE ( 2 ) ) and nitrite ( NO ( 2 ) ( - ) ) levels in an apparently coordinated fashion
Lahiri et al., Am J Physiol Lung Cell Mol Physiol 2001
:
IL-6 , IL-11, and OSM alone
had no effect on
COX-2 expression
Moore et al., J Appl Physiol 2001
:
In human cultured airway smooth muscle cells,
interleukin (IL)-1 beta
increases cyclooxygenase
(COX)-2 expression and PGE ( 2 ) release, ultimately resulting in decreased beta-adrenergic responsiveness
Wang et al., Scand J Gastroenterol 2002
(Carcinoma, Squamous Cell...) :
59 ESCC samples were used to assess COX-2 expression in the tumor cells and four ESCC cell lines to investigate the
effects of phorbol myristate acetate ( PMA ), platelet activating factor (PAF), n-sodium butyrate ( n-BT ) and
interleukin-6 (IL-6) on the expression of
COX-2 ... PKC inhibitor, however, could abrogate PMA induced COX-2 gene expression, but it did not block
IL-6 induced
COX-2 expression ... Nonetheless,
IL-6 induced
COX-2 expression could be independent of PKC activation
Basu et al., Glia 2002
(Brain Injuries...) :
These studies demonstrated that IL-1beta, TNFalpha,
IL-6 , but not IFN-gamma
increase the expression of
Cox-2 , whereas they all increase the expression of HCK and FAK ... However, TGFbeta1 was ineffective in antagonizing the
induction of
Cox-2 by either
IL-6 or TNFalpha
Dongari-Bagtzoglou et al., Inflamm Res 2003
:
CD40 ligation triggers COX-2 expression in endothelial cells : evidence that CD40 mediated
IL-6 synthesis is
COX-2 dependent ... Moreover, the data strongly suggest that CD154 induced
IL-6 secretion in HUVEC is
dependent on
COX-2 activity
Moon et al., Toxicol Appl Pharmacol 2003
:
Cyclooxygenase-2 mediates
interleukin-6 upregulation by vomitoxin ( deoxynivalenol ) in vitro and in vivo ... Taken together, these in vitro and in vivo data suggest that VT-induced
COX-2 gene expression and resultant COX-2 metabolites
contributed , in part, to subsequent upregulation of
IL-6 gene expression, which has been previously shown to be a hallmark of VT-mediated immunotoxicity
Soloff et al., Endocrinology 2004
:
In situ analysis of
interleukin-1 induced transcription of
cox-2 and il-8 in cultured human myometrial cells
Bukata et al., J Orthop Res 2004
(Osteolysis...) :
Interestingly,
COX-2 was also
required for
IL-6 production in these assays, which could be rescued by the addition of exogenous PGE2 ( 10 ( -6 ) M )
Tipton et al., J Periodontol 2003
(Periodontitis) :
The selective
COX-2 inhibitors, but not indomethacin,
caused partial ( generally up to approximately 60 % ), dose dependent decreases in IL-1beta stimulated
IL-6 in all cell lines ( P < or = 0.003 )
Harizi et al., Cell Immunol 2004
:
Exogenous IL-10, but not
IL-6 , dose-dependently
suppresses COX-2 protein expression and PGE ( 2 ) production, and TNF-alpha does not reverse this effect
Stamp et al., J Rheumatol 2004
:
Paracrine upregulation of monocyte
cyclooxygenase-2 by mediators produced by T lymphocytes :
role of
interleukin 17 and interferon-gamma
Kagiwada et al., Endocrinology 2004
(Fever) :
Cyclooxygenase (Cox)-2 expression in the brain was strongly
induced 1.5 h after injection of IL-1alpha, whereas
IL-6 expression was observed 3 h after the injection
Park et al., Int J Biochem Cell Biol 2004
(Bone Resorption) :
IL-1beta and
IL-6 and, to a lesser extent, TNF-alpha,
enhances COX-2 mRNA levels in calvarial osteoblasts ... In contrast, the presence of TGF-beta reduced
COX-2 mRNA level, PGE ( 2 ) biosynthesis and bone resorption
induced by IL-1beta, TNF-alpha,
IL-6 or a combination thereof
Dawn et al., Cardiovasc Res 2004
(Myocardial Infarction...) :
However, following a PC stimulus,
IL-6 is obligatorily
required for the activation of the JAK-STAT pathway, the ensuing upregulation of iNOS and
COX-2 ( co-mediators of late PC ), and the development of a cardioprotective phenotype
Ha et al., J Leukoc Biol 2005
:
Inhibition of
cyclooxygenase 2 significantly
reduced the PSG17N mediated increase in IL-10 and
IL-6
Attar et al., Hum Reprod Update 2006
(Endometriosis...) :
COX-2 in turn is
stimulated by E ( 2 ),
interleukin-1beta (IL-1beta) and PGE ( 2 ) itself in endometrial and endometriotic cells
Jin et al., J Ethnopharmacol 2006
(Bone Resorption...) :
IL-1beta and
IL-6 and to a lesser extent TNF-alpha,
enhanced COX-2 mRNA levels in calvarial osteoblasts ... TGF-beta, YJ ( 100microg/ml ) and their combinations of YJ+TGF-beta reduced the
COX-2 mRNA level, PGE2 biosynthesis and bone resorption
induced by IL-1beta, TNF-alpha,
IL-6 or their combination
Yu et al., Hepatology 2006
(Choline Deficiency...) :
In conclusion, induction of
COX-2 occurs in association with NF-kappaB activation and upregulation of TNF-alpha,
IL-6 , and ICAM-1 in MCD diet
induced steatohepatitis
Chen et al., Eur J Pharmacol 2006
:
We show that dipyridamole inhibited
interleukin-6 and monocyte chemoattractant protein-1 secretion, inducible nitric oxide synthase protein expression, nitrite accumulation, and
cyclooxygenase-2 (COX-2) induction in lipopolysaccharide (LPS) activated RAW 264.7 macrophages
Chen et al., J Immunol 2006
:
Peptidoglycan induced
IL-6 production in RAW 264.7 macrophages is
mediated by
cyclooxygenase-2 , PGE2/PGE4 receptors, protein kinase A, I kappa B kinase, and NF-kappa B ... PGN mediated
IL-6 production was
inhibited by a nonselective cyclooxygenase (COX) inhibitor ( indomethacin ), a selective
COX-2 inhibitor ( NS398 ), a PGE ( 2 ) ( EP2 ) antagonist ( AH6809 ), a PGE ( 4 ) ( EP4 ) antagonist ( AH23848 ), and a protein kinase A (PKA) inhibitor ( KT5720 ), but not by a nonselective NO synthase inhibitor ( N ( G ) -nitro-l-arginine methyl ester )
Aoki et al., Am J Physiol Cell Physiol 2007
:
These data indicate that Smad2/3 dependent pathway plays a central role in
COX-2 induction by TGF-beta1, IL-1beta, and
IL-6
Sooranna et al., Mol Hum Reprod 2006
:
In primary cultures of uterine myocytes, cPLA(2) mRNA expression was increased by IL-1beta and
IL-6 ;
PGHS-2 mRNA expression was
increased by IL-1beta, PGE ( 2 ) and stretch ; and PGES-1 mRNA expression was increased by IL-1beta only
Yu et al., Gut 2007
(Hepatitis, Animal) :
Hepatic
COX-2 expression in the TG mice
resulted in activation of NF-kappaB and inflammatory cytokine cascade, with a marked expression of the proinflammatory cytokines tumour necrosis factor (TNF)-alpha ( 9.4-fold ),
interleukin (IL)-6 ( 4.4-fold ), IL-1beta ( 3.6-fold ), and of the anti-inflammatory cytokine IL-10 ( 4.4-fold ) and chemokine macrophage inflammatory protein-2 ( 3.2-fold )
Wu et al., Prostaglandins Other Lipid Mediat 2007
:
In this review, we provide evidence for reduced
COX-2 transcriptional expression in
response to phorbol esters ( PMA ), lipopolysaccharide (LPS),
interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha)
Wu et al., Reprod Sci 2007
(Endometriosis) :
These results, along with recent findings that TSA suppresses proliferation,
interleukin-1 beta
induced cyclo-oxygenase 2 expression, and constitutive or TNFalpha stimulated nuclear factor kappa B activation in endometrial and endometriotic cells, makes histone deacetylase inhibitors a promising class of compounds for novel and more effective medical treatment of endometriosis, especially given the mounting evidence that endometrios be an epigenetic disease
L'Eplattenier et al., J Vet Intern Med 2007
(Dog Diseases...) :
In addition, a neoplastic and a nonneoplastic canine prostatic cell line were used to investigate the
effects of
interleukin-6 (IL-6) , tumor necrosis factor-alpha (TNF-alpha), phorbol 12-myristate 13-acetate ( PMA ), epithelial growth factor (EGF), and specific signal transduction pathway inhibitors on
COX-2 expression ... In vitro, TNF-alpha,
IL-6 , and EGF
increased COX-2 expression in nonneoplastic cells but not in PCA cells, where baseline expression was high
Chida et al., Biochem Biophys Res Commun 2007
(Fever) :
Only IL-1alpha, but not TNFalpha,
induced IL-6 in the IL-1alpha/beta/TNFalpha KO mouse brain, while both cytokines induced
cyclooxygenase (Cox)-2
Krady et al., J Neurosci Res 2008
:
We show that CNTF reduces COX-2 levels, whereas
IL-6 increases the expression of IL-1beta, TNFalpha, and
Cox-2
Moon et al., Free Radic Biol Med 2008
:
These results show that exogenous NO can increase
COX-2 dependent PGD ( 2 ) and
IL-6 production by MC in inflammatory environments through the p38 MAPK pathway
Zhao et al., Am J Respir Cell Mol Biol 2009
:
In addition, inhibition of
COX-2 partly
attenuated PM-induced Prostaglandin E2 and
IL-6 release
Ara et al., Cancer Res 2009
(Bone Marrow Neoplasms...) :
IL-6 induced the expression of
cyclooxygenase-2 in neuroblastoma cells with concomitant release of prostaglandin-E2, which increased the expression of IL-6 by BMSC
Chikuma et al., J Mol Neurosci 2009
:
These results indicate that
interleukin-6/soluble interleukin-6 receptor complexes and the signal transducer 130-kDa glycoprotein
play an important role in the regulation of
cyclooxygenase-2 expression and subsequent prostaglandin E ( 2 ) formation in mouse astrocytes and that interleukin-6 is an important regulator of immune and inflammatory processes in the CNS
Pagel et al., Bone 2009
:
Furthermore, in the
presence of the selective
cyclooxygenase-1 and -2 inhibitors SC-560 and NS-398 thrombin induced
interleukin-6 release was prevented
Nakajima et al., J Neurotrauma 2010
(Inflammation...) :
Phosphorylation of STAT3, which is
activated by
IL-6 , and expression of inducible
cyclooxygenase-2 (COX-2) were also compared between the taurine treatment group ( 250 mg/kg ) and the control group by Western blot analysis
Lee et al., Am J Pathol 2010
(Inflammation) :
These results demonstrate that LTA induced MAPKs activation is mediated through the TLR2/MyD88/PI3K/Rac1/Akt pathway, which in turn initiates the activation of NF-kappaB, and ultimately induces
cPLA(2)/COX-2 dependent PGE ( 2 ) and
IL-6 generation
Vinukonda et al., Brain 2010
(Disease Models, Animal...) :
Cyclooxygenase-2 or prostanoid receptor-1 inhibition
reduced tumour necrosis factor-a level, but not
interleukin-1ß
Shah et al., Nat Prod Res 2010
:
PBMCs were treated with various concentrations of curcumin, resveratrol and parthenolide and tested for the abilities of these natural products to protect against the LPS induced expression, secretion of the pro-inflammatory cytokines TNFalpha, IL-1beta and
IL-6 and
activation of the pro-inflammatory
COX-2
Gao et al., Toxicol Appl Pharmacol 2010
:
IL-6 induced by Ni/MALP-2 co-exposure was partially
dependent on activity of HIF-1alpha and
COX-2 as shown by targeted knockdown using siRNA
Yoon et al., PloS one 2011
(Graves Disease...) :
Quercetin significantly attenuated intercellular adhesion molecule-1 ( ICAM-1 ), interleukin (IL) -6, IL-8, and cyclooxygenase
(COX) -2 mRNA expression, and
inhibited IL-1ß induced increases in ICAM-1,
IL-6 , and IL-8 mRNA
Martín et al., J Hypertens 2012
:
This study analyzes the effect of pioglitazone, a PPAR? agonist, on
interleukin-1ß induced
COX-2 expression and the role of reactive oxygen species ( ROS ) on this effect ... PPAR? activation with pioglitazone reduces
interleukin-1ß induced
COX-2 expression by interference with the redox-sensitive transcription factor NF-?B
Seo et al., Immunopharmacol Immunotoxicol 2012
(Inflammation) :
SPEE treatment significantly inhibited the LPS induced production of NO, prostaglandin E ( 2 ),
interleukin-6 , and tumor necrosis factor-a and
inhibited the expression of iNOS and
COX-2 via attenuation of NF-?B p65 expression
Szczepanski et al., Arthritis Rheum 1994
:
Induction of
cyclooxygenase II in human synovial microvessel endothelial cells by
interleukin-1
Feng et al., Arch Biochem Biophys 1993
:
In rat vascular smooth muscle cells,
interleukin-1 beta selectively
increased the expression of
COX-2 , but not that of COX-1, as assessed by enzyme activity, immunoprecipitation of COX proteins, and mRNA analysis
Yamamoto et al., J Biol Chem 1995
:
Transcriptional
roles of nuclear factor kappa B and nuclear
factor-interleukin-6 in the tumor necrosis factor alpha dependent induction of
cyclooxygenase-2 in MC3T3-E1 cells ... These data suggested a potential
role of both
NF-IL6 and NF kappa B in the induction of
cyclooxygenase-2 by TNF alpha
O'Banion et al., J Neurochem 1996
:
TPA, basic fibroblast growth factor, and the proinflammatory factors tumor necrosis factor alpha and lipopolysaccharide, but not
interleukin-6 , also
stimulated PGHS-2 mRNA expression
Kawaguchi et al., J Bone Miner Res 1996
(Bone Resorption) :
We conclude that ( 1 ) IL-1, TNF-alpha, and PTH, but not
IL-6 nor IL-11, can
increase the expression of
PGHS-2 , cPLA2, and PGE2 production in cultured mouse calvariae ; ( 2 ) IL-4 inhibits PGE2 production in both control and stimulated calvarial cultures by inhibiting PGHS-2 and cPLA2 ; and ( 3 ) IL-4 has an inhibitory effect on bone resorption which is independent of PG production
Arslan et al., Prostaglandins 1996
:
In these cells,
COX-2 gene expression was
inducible by the cytokines interleukin-1 beta and tumor necrosis factor alpha, but not by
interleukin-6
Crofford et al., Arthritis Rheum 1997
(Arthritis, Rheumatoid) :
Involvement of nuclear factor kappa B in the
regulation of
cyclooxygenase-2 expression by
interleukin-1 in rheumatoid synoviocytes
Tai et al., Endocrinology 1997
:
In mouse osteoblastic cells, both IL-1alpha and
IL-6 with sIL-6R markedly
induced messenger RNA expression of
COX-2 , but not COX-1, as determined by Northern blot analysis, and luciferase activity in cells stably transfected with a COX-2 promoter-luciferase fusion construct ...
IL-6 and sIL-6R, when added separately, did not
stimulate COX-2 messenger RNA expression
Kniss et al., Am J Obstet Gynecol 1997
:
Interleukin-1 receptor antagonist blocks
interleukin-1 induced expression of
cyclooxygenase-2 in endometrium ... Experiments were conducted to examine whether interleukin-1 receptor antagonist could suppress
interleukin-1 induced
cyclooxygenase-2 expression
Williams et al., J Biol Chem 1997
:
The experimental findings demonstrate that the
effects of Cox-1 and
Cox-2 activity on macrophage
IL-6 synthesis are segregated
Ohara et al., Anesthesiology 1998
:
Induction of
cyclooxygenase-2 in alveolar macrophages after acid aspiration : selective cyclooxygenase-2 blockade
reduces interleukin-6 production ... Selective
cyclooxygenase-2 blockade
reduced production of
interleukin-6 by acid stimulated alveolar macrophages
Staels et al., Nature 1998
(Coronary Disease...) :
In these smooth-muscle cells, we find that PPARalpha ligands, and not PPARgamma ligands, inhibit
interleukin-1 induced production of interleukin-6 and prostaglandin and expression of
cyclooxygenase-2
Longo et al., Mediators Inflamm 1998
:
The
role of cyclooxygenase-1 and
cyclooxygenase-2 in lipopolysaccharide and
interleukin-1 stimulated enterocyte prostanoid formation