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AKT1 — PTPN11

Pathways - manually collected, often from reviews:

• NCI Pathway Database Fc-epsilon receptor I signaling in mast cells: GAB2/PI3K/SHP2 complex (GAB2-PTPN11-PIK3CA-PIK3R1) → AKT1 (AKT1) (modification, activates)
• NCI Pathway Database IL6-mediated signaling events: GRB2/SOS1/GAB family/SHP2/PI3K complex (GRB2-SOS1-GAB1_GAB2-PTPN11-PIK3CA-PIK3R1) → AKT1 (AKT1) (modification, activates) Jee et al., J Invest Dermatol 2002
  Evidence: mutant phenotype
• WikiPathways Hepatitis C and Hepatocellular Carcinoma: AKT1 → PTPN11 (activation)

Text-mined interactions from Literome

Hakak et al., Oncogene 2000 : Shp-2 mediates v-Src induced morphological changes and activation of the anti-apoptotic protein kinase Akt ... Shp-2 deficiency also reduced v-Src induced activation of the anti-apoptotic protein kinase Akt ... Since activation of Akt is dependent on PI3-kinase, this suggests that the effect of Shp-2 on Akt activation may be mediated, at least in part, by its effects on the interaction between PI3-kinase and Cbl
Lima et al., Endocrine 2002 (Diabetes Mellitus, Experimental...) : In the present study, we investigated insulin induced IRS-1/SHP2 and IRS-1/PI 3-kinase associations and the regulation of a downstream serine-kinase AKT/PKB in liver and muscle of three animal models of insulin resistance : STZ diabetes, epinephrine treated rats, and aging, which have alterations in IRS-1 tyrosine phosphorylation in common
Ruhul Amin et al., Oncogene 2002 : Taken together, our results strongly suggest that activation of Erk 1/2 and Akt by proinflammatory cytokines requires tyrosine phosphorylation of SHPS-1 and subsequent association of SHPS-1 with SHP-2
D'Alessio et al., Endocrinology 2003 : Furthermore, we show that Shp-2 activity is required for RetM918T induced Akt activation
Ivins Zito et al., J Cell Physiol 2004 : Whether SHP-2 regulates insulin-like growth factor-1 (IGF-1) dependent activation of Akt at the level of PI3K has yet to be established
Maeda et al., Biochem Biophys Res Commun 2004 : Expression of Gab1 PI3K-m in SK-N-MC human primitive neuroectodermal tumor cells expressing wild-type RET markedly impaired Akt phosphorylation, Rac1 activation, and lamellipodia formation that were induced by GDNF whereas expression of Gab1 SHP2-m partially impaired Erk activation
Haider et al., Mol Pharmacol 2005 : Resveratrol inhibits angiotensin II- and epidermal growth factor mediated Akt activation : role of Gab1 and Shp2
Ruhul Amin et al., Genes Cells 2007 : Moreover, Con A activates Akt in a SHP-2 dependent manner
Liu et al., J Clin Invest 2011 (Brain Neoplasms...) : Furthermore, inhibition of SHP-2 by shRNAs or pharmacological inhibitors disrupted the interaction of PI3K with PDGFRa, suppressed downstream AKT/mTOR activation, and impaired tumorigenesis of Ink4a/Arf-null cells, whereas expression of an activated PI3K mutant rescued the effect of SHP-2 inhibition on tumorigenicity
Liu et al., PloS one 2011 : Finally, it has been identified that SHP-2 was involved in activation of Akt and extracellular regulated kinases 1 and 2 ( ERK1/2 ) induced by T3 in oligodendrocytes