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EPHB2 — PTPN7

Text-mined interactions from Literome

Saxena et al., J Biol Chem 1999 : Efforts to pinpoint the exact site of action and specificity of HePTP in the signaling cascade revealed that HePTP acts directly on the mitogen activated protein ( MAP ) kinases Erk1 and 2 and consequently reduces the magnitude and duration of their catalytic activation in intact T cells
Pettiford et al., Oncogene 2000 : Together, these data identify ERK2 as a specific and direct target of HePTP and are consistent with a model in which HePTP negatively regulates ERK2 activity as part of a feedback mechanism
Pettiford et al., Leukemia 2003 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : The protein tyrosine phosphatase HePTP regulates nuclear translocation of ERK2 and can modulate megakaryocytic differentiation of K562 cells ... However, antisense inhibition of HePTP enhanced nuclear translocation of ERK and the expression of the megakaryocytic markers CD41 and IL-6 ... They further show that HePTP is involved in the regulation of nuclear translocation of ERK2 and that HePTP protein levels can modulate K562 cell differentiation
Sergienko et al., ACS Chem Biol 2012 : Here, we report the development of a small molecule that augments ERK1/2 and p38 activation in human T cells, specifically by inhibiting HePTP