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IL6 — PTX3

Text-mined interactions from Literome

Poulakis et al., Respir Med 1999 (Lung Diseases) : The aim of this study was to investigate the effects of pentoxifylline ( PTX ) on the production of TNF-alpha, IL-1 beta, IL-6 and GM-CSF by lipopolysaccharide (LPS) stimulated alveolar macrophages ( AM )
Guo et al., Eur J Endocrinol 2000 (Bone Resorption...) : ( 1 ) PTX decreases bone resorption immediately and ( 2 ) circulating IL-6 is not involved in the changes in bone turnover immediately after PTX
Marcinkiewicz et al., Immunopharmacology 2000 : PTX also affects the production of other cytokines such as IL-1, IL-6 , IL-10, IL-12, and IFN-gamma
Hoebe et al., Biochem Pharmacol 2001 : PTX completely inhibited LPS induced TNF-alpha production and attenuated IL-6 only after 48 hr of incubation
Klouche et al., AIDS 2002 (Acute-Phase Reaction...) : Human herpesvirus 8-derived viral IL-6 induces PTX3 expression in Kaposi 's sarcoma cells
Schandené et al., Immunology 1992 : In this study, we found that PTX differentially regulates the production of TNF-alpha and interleukin-6 (IL-6) ... Indeed, PTX at high concentrations triggers the production of IL-6 but not of TNF-alpha by peripheral blood mononuclear cells ( PBMC ) ... Further experiments indicated that monocytes are responsible for this PTX induced IL-6 production ... In this system, PTX was found to inhibit the secretion of both TNF-alpha and IL-6 by T cells ... We suggest that cAMP could be involved in these differential effects of PTX on production of TNF-alpha and of IL-6
Banfi et al., J Pharmacol Exp Ther 2004 (Brain Ischemia...) : PTX treatment did induce a greater increase of serum tumor necrosis factor-alpha (TNF-alpha), but not of interleukin (IL)-1beta and IL-6 induced by in vivo administration of lipopolysaccharide (LPS), which suggests a protective role for TNF-alpha
Ji et al., Ann Clin Lab Sci 2004 (Disease Models, Animal...) : At all dosages, PTX reduced the activation of NF-kappaB and the production of TNF-alpha and IL-6 , but enhanced the release of IL-10 ... In conclusion, PTX suppressed the production of proinflammatory cytokines such as TNF-alpha and IL-6 in rat intestine, and enhanced the endotoxin induced production of IL-10
Volman et al., Intensive Care Med 2005 (Multiple Organ Failure) : Although PTX inhibited the lipopolysaccharide induced increase in tumor necrosis factor alpha and interleukin 6 expression ( but not interleukin 1beta expression ) at both mRNA and protein level in a murine macrophage cell line, tumor necrosis factor alpha mRNA expression in the livers of PTX treated mice was not significantly inhibited
Rizzi et al., J Immunol 2006 : In these cells, PTX-B neither down-regulated the IL-6R nor prevented IL-6 induced signaling in terms of STAT3 phosphorylation and DNA binding
Tian et al., Proc Natl Acad Sci U S A 2006 (Reperfusion Injury) : The superior effects of PTX are mediated by IL-6
Schneider et al., Infect Immun 2007 : Stimulation of T cells with holotoxin ( PTx ) or the B subunit alone ( PTxB ) rapidly induces signaling events resulting in inositol phosphate accumulation, Ca ( 2+ ) mobilization, interleukin-2 (IL-2) production, and mitogenic cell growth
Yosef-Levi et al., Harefuah 2007 (Cardiovascular Diseases) : CRP is a pentraxin regulated mainly by IL-6
Zhao et al., Biochem Biophys Res Commun 2008 (Encephalomyelitis, Autoimmune, Experimental...) : Moreover, icv PTx induced Th17 infiltration and increased expression of cytokines IL-6 and TGF-beta
Spach et al., J Immunol 2009 (Encephalomyelitis, Autoimmune, Experimental...) : However, only RANTES, IL-6 , and IFN-gamma increased significantly with both genetic compensation and PTX treatment
Szajnik et al., Oncogene 2009 (Carcinoma...) : In MyD88 ( + ) SCOV3 cells, LPS or PTX binding to TLR4 induced IRAK4 activation and cJun phosphorylation, activated the NF-kappaB pathway and promoted interleukin (IL)-8, IL-6 , vascular endothelial growth factor and monocyte chemotactic protein-1 production and resistance to drug induced apoptosis
Richard et al., Brain Pathol 2011 (Encephalomyelitis, Autoimmune, Experimental) : In a series of experiments using DNA microarrays, knockout mice and neutralizing antibodies, we found that PTX acts indirectly on the endothelium in part through IL6 , which is essential for the post-transcriptional upregulation of intercellular adhesion molecule 1 ( ICAM1 ) in response to PTX but not to LPS
Roy et al., Journal of neuroinflammation 2012 (Disease Models, Animal...) : IL-6 upregulated CXCL1 expression in brain endothelial cells by acting transcriptionally and mediated the stimulatory effect of PTX on CXCL1 expression
Yamamoto et al., Hemodial Int 2013 (Cardiovascular Diseases...) : While C-reactive protein did not change, interleukin-6 (IL-6) increased by 14 % and pentraxin 3 (PTX3) increased by 45 %
Yang et al., Int J Nanomedicine 2013 : In addition, the PTX-NPs markedly inhibited interleukin-6 secretion, increased caspase-8, caspase-9, and caspase-3 expression, and induced apoptosis of tumor cells in the treated mice
Neuner et al., Immunology 1994 : Due to the therapeutic implications, the present study addressed the in vivo effects of PTX on the release of TNF-alpha, IL-1 beta, IL-6 and IL-8 by human peripheral blood mononuclear cells ( PBMC )
Bernard et al., J Cardiovasc Pharmacol 1995 : Because inflammatory processes involve both leukocytes and vascular cells, we tested the effects of PTX on TNF and interleukin-6 (IL-6) production by the vessel wall in response to lipopolysaccharide (LPS)
Okuda et al., Immunopharmacology 1996 (Encephalomyelitis, Autoimmune, Experimental) : Semiquantitative reverse transcriptase-polymerase chain reaction analysis revealed that PTX at this dose reduced the mRNA levels for tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-6 in peripheral blood mononuclear cells ( PBMC ) of mice with EAE
Tsang et al., ASAIO J 1996 (Albuminuria) : A double blind, prospective, randomized, placebo controlled, parallel study was undertaken to assess the effect of PTX on leukotriene B4, complement fragment C3a, interleukin 6 (IL6), endothelial injury as measured by von Willebrand factor (vWf), and endothelial permeability as measured by urinary albumin excretion ( expressed as excreted urinary albumin to creatinine ratio [ ACR ] ) in patients undergoing cardiopulmonary bypass ( CPB ) for elective coronary artery bypass grafting
Dong et al., J Clin Immunol 1997 : PTX at a 3.5 x 10 ( -5 ) M concentration significantly inhibited T cell proliferation and the production of tumor necrosis factor-alpha, interleukin-2 , and interleukin-4
D'Hellencourt et al., Int J Immunopharmacol 1996 : We investigated PTX effects on production and mRNA expression of TNF alpha, IL-1 beta, IL-6 , IL-8, TNF beta and IL-10 ... We also noted that the effects of PTX on IL-6 , IL-8 and IL-10 production were different in WB and in PBMC culture
Schratzberger et al., Immunopharmacology 1999 : In the present study, we investigated the effects of the anti-inflammatory drug pentoxifylline ( PTX ) on activation of endothelial cells for enhanced adhesion and transmigration of neutrophils by lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF), interleukin-1 (IL-1) and granulocyte colony stimulating factor ( G-CSF )