Gene interactions and pathways from curated databases and text-mining

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MAPK15 — RAC1

Text-mined interactions from Literome

Page et al., Am J Respir Cell Mol Biol 1999 : Together, these data suggest that in bovine tracheal myocytes : ( 1 ) activation of MAPK by PDGF is dependent on Ras ; ( 2 ) active Ras is sufficient for ERK activation but is insufficient for maximal activation of JNK or p38 ; ( 3 ) activation of Rac1 is sufficient for maximal JNK activation ; and ( 4 ) Ras, MEK, and ERK constitute a distinct pathway to cyclin D1 transcriptional activation
Mainiero et al., Immunity 2000 (MAP Kinase Signaling System) : Finally, we provide direct evidence that p95 Vav and Rac control the activation of p38 MAPK triggered by beta1 integrins
Versteeg et al., J Biol Chem 2000 : In turn Rac mediates p38 mitogen activated protein ( MAP ) kinase activation and cytoskeletal reorganization, whereas factor VIIa induced p42/p44 MAP kinase stimulation required PI3K enzymatic activity but was not inhibited by dominant negative Rac proteins
Pomerance et al., J Biol Chem 2000 : Expression of the dominant negative form of Rac1 , but not that of Ras, blocked forskolin induced p38-MAPK activation
Yasui et al., J Biol Chem 2001 : Thus, the differential activation of Rac1 and localization of active Rac1 contribute to the difference in the ability of NGF and EGF to induce neurite outgrowth, and we propose that the MAPK cascade independent prompt activation of Rac1 and recruitment of active Rac1 at the protrusion sites trigger the initiation of neurite formation
Rul et al., Ann N Y Acad Sci 2002 (MAP Kinase Signaling System) : Here, we describe that the inhibition of Rac1 or Cdc42 signaling leads to MAPK ERK activation via a pathway involving PI(3)K, Akt, Raf, and MEK, but not Ras
Zhong et al., Blood 2003 (MAP Kinase Signaling System) : Rac and Cdc42, but not Ras or Rho, were responsible for this MAPK/ERK activation ... PAK1 ( p21 activated kinase 1 ) activation is induced by C albicans, suggesting that PAK1 may also be involved in the Rac1 activation of MAPK/ERK ... We conclude from these data that Rac/Cdc42 dependent activation of MAPK/ERK is a critical event in the immediate phagocytic response of PMNs to microbial challenge
Vial et al., Cancer Cell 2003 (Colonic Neoplasms...) : ERK-MAPK signaling coordinately regulates activity of Rac1 and RhoA for tumor cell motility
Chen et al., Mol Microbiol 2004 (MAP Kinase Signaling System) : Co-expression of DARas with dominant active Rac ( DARac ) stimulates MAPK activation and restores the wild-type phenotype
Nishida et al., J Biol Chem 2005 : Dominant negative Rac inhibited angiotensin II-stimulated ROS production, JNK activation, and p38 MAPK activation but did not affect ERK activation
Malchinkhuu et al., Oncogene 2005 (Glioma) : Inhibition of Rac1 suppressed JNK but not p38MAPK , while the activity of p38MAPK was abolished by a dominant negative form of Cdc42
Tcherkezian et al., Mol Cell Biol 2005 : Together, these data suggest that CdGAP is a novel substrate of ERK1/2 and mediates cross talk between the Ras/mitogen activated protein kinase pathway and regulation of Rac1 activity
Otis et al., Mol Cell Endocrinol 2007 : The increase in cell protein content induced by Ang II entails formation of a cortical actin ring and Rac dependent activation of p42/p44(mapk) and p38 MAPK
Zuluaga et al., FEBS Lett 2007 : p38alpha MAPK can positively or negatively regulate Rac-1 activity depending on the presence of serum ... The small GTP-ase Rac-1 can trigger p38 MAPK activation and, in turn, p38alpha can regulate signalling pathways that potentially impinge on Rac-1 activity
Flevaris et al., Blood 2009 (MAP Kinase Signaling System) : Importantly, integrin dependent MAPK activation, MAPK dependent MLC phosphorylation, and clot retraction are inhibited by a Rac1 inhibitor and in Rac1 knockout platelets, indicating that integrin induced activation of MAPK and MLC and subsequent clot retraction is Rac1 dependent
Osada et al., J Biochem 2009 (MAP Kinase Signaling System) : Finally, lowering the expression of GULP abrogated MAPK phosphorylation, and the presence of MAPK inhibitors reduced the level of GTP bound Rac1 in PS-activated phagocytes ... These results collectively suggested the following signalling pathway for the SR-BI induced phagocytosis : ( i ) PS-recognizing SR-BI activates associated GULP ; ( ii ) activated GULP induces MAPK phosphorylation ; ( iii ) activated MAPK increases GTP bound Rac1 ; and ( iv ) activated Rac1 induces a rearrangement of the actin cytoskeleton
Huang et al., J Biol Chem 2011 : Here, we show that ARV induced phosphorylation of caveolin-1 ( Tyr ( 14 ) ), dynamin-2 expression, and Rac1 activation through activation of p38 MAPK and Src in the early stage of the virus life cycle is beneficial for virus entry and productive infection
Pignatelli et al., J Cell Biol 2012 : Hic-5 also induced matrix degradation, cell migration, and invasion in the absence of TGF-ß via Rac1 regulation of p38 MAPK