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JUN — RAF1

Text-mined interactions from Literome

Yu et al., Mol Pharmacol 2001 : Interestingly, resveratrol had little effect on the induction of AP-1 reporter gene by active Raf-1 , MEKK1, or MKK6, suggesting that it inhibited MAPK pathways by targeting the signaling molecules upstream of Raf-1 or MEKK1
Yu et al., Oncogene 2004 (Leukemia) : These events were accompanied by the caspase independent downregulation of Raf-1 , inactivation of MEK1/2, ERK, Akt, p70S6K, dephosphorylation of GSK-3, and activation of c-Jun-N-terminal kinase (JNK) and p38 MAPK
Pap et al., Arthritis Rheum 2004 (Arthritis, Rheumatoid) : Immunohistochemistry was used to study the effects of DN c-Raf-1 on phosphorylated c-Jun and matrix metalloproteinase 1 (MMP-1) in RASFs implanted into SCID mice ... DN c-Raf-1 decreased the phosphorylation of ERK and JNK in vitro and reduced the in vivo expression of phosphorylated c-Jun as well as the expression of disease-relevant MMPs
Bodart et al., Dev Biol 2005 : Differential roles of p39Mos-Xp42Mpk1 cascade proteins on Raf1 phosphorylation and spindle morphogenesis in Xenopus oocytes
Lim et al., American journal of translational research 2009 : Ras-Raf1-ERK1/2 dependent AP-1 activation positively regulates MUC5AC mucin induction by S. pneumoniae, whereas MEKK3-JNK1/2 dependent AP-1 activation negatively regulates it
Li et al., EMBO J 1995 : The same results were obtained in vivo using transfection assays ; 14-3-3 enhanced both c-Raf-1- and Raf-1 kinase domain stimulated expression of AP-1- and NF-kappa B-dependent reporter genes and accelerated Raf-1 kinase domain triggered differentiation of PC12 cells
Natoli et al., Oncogene 1994 : We show by use of Ha-Ras and Raf-1 dominant negative mutants that both Ha-Ras and Raf-1 are required for pX-induced activation of c-Jun transcriptional activity