Gene interactions and pathways from curated databases and text-mining

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RALA — SRC

Pathways - manually collected, often from reviews:

  • Reactome Reaction: RALA → SRC (reaction)

Text-mined interactions from Literome

Goi et al., EMBO J 2000 : These results identify a role for Ral-GTPases in the activation of c-Src by EGF receptors and the coupling of EGF to transcription through Stat3 and the actin cytoskeleton through cortactin
Ladeda et al., Biochem Biophys Res Commun 2001 : RalA mediates v-Src , v-Ras, and v-Raf regulation of CD44 and fibronectin expression in NIH3T3 fibroblasts
Senga et al., J Biol Chem 2001 (Leukemia, Myeloid) : Recently, it was proven that Ral regulates c-Src activity and subsequent phosphorylation of its substrate, STAT3
Jiang et al., Nature 1995 : Overexpression of RalA potentiated PLD activation by v-Src, and expression of dominant negative RalA mutants inhibited both v-Src- and v-Ras induced PLD activity