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RALA — SRC
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
RALA
→
SRC
(reaction)
Text-mined interactions from Literome
Goi et al., EMBO J 2000
:
These results identify a
role for
Ral-GTPases in the activation of
c-Src by EGF receptors and the coupling of EGF to transcription through Stat3 and the actin cytoskeleton through cortactin
Ladeda et al., Biochem Biophys Res Commun 2001
:
RalA mediates
v-Src , v-Ras, and v-Raf regulation of CD44 and fibronectin expression in NIH3T3 fibroblasts
Senga et al., J Biol Chem 2001
(Leukemia, Myeloid) :
Recently, it was proven that
Ral regulates
c-Src activity and subsequent phosphorylation of its substrate, STAT3
Jiang et al., Nature 1995
:
Overexpression of RalA potentiated PLD activation by v-Src, and expression of dominant negative
RalA mutants
inhibited both
v-Src- and v-Ras induced PLD activity