Gene interactions and pathways from curated databases and text-mining

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NOTCH2 — RBBP7

Text-mined interactions from Literome

Hughes et al., Cancer Treat Res 2009 (Bone Neoplasms...) : Further, exposure to valproic acid at therapeutic concentrations induced expression of Notch genes and caused a 250-fold increase in invasiveness for non-invasive cell lines, but had no discernible effect on those lines that expressed high levels of Notch without valproic acid treatment, suggesting a role for HDAC in regulating Notch pathway expression in osteosarcoma
Tang et al., Journal of the American Heart Association 2012 : However, inhibition of HDAC activity did not suppress Notch activation of the HRT target genes ... Although CBF-1 mediated Notch signaling was increased by HDAC inhibition in human SMCs and in a C3H10T1/2 model, SMC differentiation was inhibited in both cases ... Although CBF-1 mediated Notch signaling is not suppressed by HDAC inhibition, HDAC activity is required for Notch differentiation signals through mitogen activated protein kinase and PI3K pathways in SMCs. ( J Am Heart Assoc. 2012 ; 1 : e000901 doi : 10.1161/JAHA.112.000901 )