Kim et al., J Biol Chem 2006
(Down Syndrome...) :
To elucidate the molecular basis of these anti-inflammatory effects, we analyzed the role of DSCR1 in the regulation of NF-kappaB transactivation using glioblastoma cells stably transfected with DSCR1.4 or its truncation mutants ( DSCR1.4- ( 1-133 ) and DSCR1.4- ( 134-197 ) )
Schweighofer et al., Clin Hemorheol Microcirc 2007
:
DSCR1 is induced by NFAT or NF-kappaB and limits Ca ( ++ ) signaling in a negative feed-back loop
Lee et al., Biochim Biophys Acta 2009
:
DSCR1-1S also stimulated IL-1R mediated signaling pathways, TAK1 activation, NF-kappaB transactivation, and IL-8 production, all downstream consequences of IL-1R activation