Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Xie et al., Ann Clin Lab Sci 2010 (Endotoxemia) : The infusion of HES130/0.4 in endotoxemic rats, especially 15 ml/kg, significantly reduced the release of plasma TNF-alpha and IL-1beta, which was consistent with the observed inhibitory effects of HES130/0.4 on NF-kappaB activation, TLR4 mRNA expression, and TLR4 protein level in monocytes
Lv et al., J Int Med Res 2005 (Endotoxemia...) : HES also decreased the number of MPO positive cells induced by LPS and inhibited activation of NF-kappaB and AP-1
Wang et al., Int Immunopharmacol 2009 (Disease Models, Animal...) : In addition, both HES and BL could attenuate the increase in TNF-alpha, IL-6, MPO levels and NF-kappaB activation
Tian et al., Acta Anaesthesiol Scand 2005 : 3.75 and 7.5 ml/kg HES suppressed LPS induced NF-kappaB activation in the four tissues and decreased plasma TNF-alpha elevation
Feng et al., Int Immunopharmacol 2010 (Disease Models, Animal...) : Meanwhile, HES could significantly reduce TNF-alpha, IL-6, and ICAM-1 mRNA, inhibit NF-kappaB activation, and down-regulate TLR2 and TLR4 expression in the brain
Lv et al., Acta Anaesthesiol Scand 2005 : Similarly, HES could inhibit hepatic NF-kappaB and AP-1 activations
Karlsson et al., Cells Tissues Organs 2008 (Osteoarthritis) : The effect of NFkappaB activation on HES5 transcription was studied using the NFkappaB inhibitor pyrrolidine dithiocarbamate
Lv et al., Ann Clin Lab Sci 2005 (Sepsis) : HES also down-regulated pulmonary proinflammatory cytokines ( TNF-alpha, IL-1beta, and IL-6 ) and mRNA expressions ( CINC and P-selectin ), and inhibited pulmonary activities of NF-kappaB and AP-1