Gene interactions and pathways from curated databases and text-mining

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IL1B — RELA

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Lee et al., Biochem Biophys Res Commun 2009 (Arthritis, Rheumatoid) : Infection of FLS with Ad-IkappaB alpha ( S32A, S36A ), an adenovirus containing mutant IkappaB alpha, inhibited IL-1beta induced nuclear translocation and DNA binding of NF-kappaB
Yu et al., J Am Soc Nephrol 2002 : TSA inhibited induction of endogenous NO production and iNOS as well as NF-kappa B element promoter activity in response to interleukin-1 beta (IL-1 beta) or lipopolysaccharide (LPS) + interferon-gamma (IFN-gamma) in both cell types without altering NF-kappa B DNA binding activity
Hellerbrand et al., Hepatology 1998 (Liver Cirrhosis, Experimental) : Proteasome inhibitors, which block the degradation of IkappaB, and the Ad5IkappaB, which provides an exogenous nondegradable IkappaB, block the stimulation of NFkappaB activity by TNFalpha and IL-1beta in activated HSCs
Yang et al., J Cell Physiol 2010 (Arthritis, Rheumatoid) : IL-1beta induced ICAM-1 expression, extracellular signal regulated kinase ( ERK ) and c-Jun-N-terminal kinase (JNK) phosphorylation, AP-1 activation, and nuclear factor-kappaB (NF-kappaB) p65 translocation were attenuated by the inhibitors of MEK1/2 ( U0126 ), JNK ( SP600125 ), AP-1 ( tanshinone IIA ), and NF-kappaB ( helenalin ) or transfection with respective short hairpin RNA plasmids ... Moreover, IL-1beta stimulated NF-kappaB p65 translocation was blocked by helenalin, but not by U0126 or SP600125, revealing that MAPKs and NF-kappaB pathways were independent on these responses
Hu et al., Frontiers in bioscience (Landmark edition) 2009 (Cardiomegaly) : In vitro experiments showed that IL-1beta stimulation also significantly reduced the association of Tollip with IRAK-1 and increased NF-kappaB binding activity in neonatal cardiomyocytes
Hu et al., Biochem J 2008 : Existence of the canonical IKK2 [ IkappaB ( inhibitor of NF-kappaB ) kinase 2 ] /IkappaBalpha pathway of NF-kappaB activation induced by IL-1beta in rabbit colonic muscle cells was validated with multiple approaches, including the induction of reporter luciferase activity and endogenous NF-kappaB-target gene expression, NF-kappaB-DNA binding activity, p65 nuclear translocation, IkappaBalpha degradation and the phosphorylation of IKK2 at Ser ( 177/181 ) and p65 at Ser ( 536 )
Lin et al., J Pharm Pharmacol 2002 : Treatment of cells with byakangelicol ( 50 microM ) or pyrrolidine dithiocarbamate ( PDTC ; 50 microM ) partially inhibited IL-1beta induced degradation of IkappaB-alpha in the cytosol, translocation of p65 NF-kappaB from the cytosol to the nucleus and the NF-kappaB-specific DNA-protein complex formation
Elouil et al., Diabetologia 2005 (MAP Kinase Signaling System) : To test this hypothesis, we compared the effects of IL-1beta , high glucose, and hydrogen peroxide, on NFkappaB DNA binding activity and target gene mRNA levels in cultured rat islets ... IL-1beta consistently increased islet NFkappaB activity and c-Myc, haeme-oxygenase 1, inducible nitric oxide synthase (iNOS), Fas, and inhibitor of NFkappaB alpha ( IkappaBalpha ) mRNA levels
Tegeder et al., J Neurosci 2004 (Disease Models, Animal...) : In cell culture experiments, S1627 inhibited interleukin (IL)-1beta stimulated nuclear translocation and DNA binding of NF-kappaB
Engelsma et al., Cytokine 2003 : Involvement of the transcription factor nuclear factor (NF)-kappaB in expression of IL-1beta1 and IL-1beta2 was demonstrated
Panopoulos et al., J Biol Chem 2005 (Inflammation) : Iron mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha induced but not interleukin-1beta induced IkappaB kinase complex/nuclear factor-kappaB activation ... l-Mimosine did not affect IKK and NF-kappaB activation by IL-1beta
Takada et al., J Immunol 2006 : It also abrogated NF-kappaB activation induced by TNF, IL-1beta , okadaic acid, doxorubicin, LPS, H2O2, PMA, and cigarette smoke
Parnet et al., J Neuroendocrinol 2003 : Activation of NF kappa B in response to IL-1 beta was no longer apparent in IL-1RI knockout mice, confirming that this receptor is essential for the transduction of IL-1 signal in the pituitary, but remained after LPS treatment
Clarke et al., Eur J Immunol 1995 : IL-4 was also found partially to inhibit NF kappa B activity induced by tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1 beta)
Guo et al., J Neurochem 2003 : Caffeic acid phenethyl ester, a potent and specific inhibitor of activation of NF-kappaB, not only blocked IL-1beta induced activation of the NF-kappaB promoter but also decreased IL-1beta induced MIP-1alpha and -1beta expression in NT2-N cells
Marumo et al., Circulation 1997 : In contrast, superoxide dismutase did not inhibit the interleukin-1beta induced NF-kappaB activation
Yan et al., Biol Reprod 2002 : In this study, we investigated the possible role of the nuclear factor kappa B (NFkappaB) in IL-1beta signaling, leading to the expression of COX-2 in human amnion cell culture
Baur et al., J Endocrinol 2000 : Electrophoretic mobility shift assays ( EMSAs ) revealed that IL-1 beta and TNF alpha activate the transcription factor NF kappa B in reaggregates of rat anterior pituitaries and in TtT/Gf cells cultured alone or cocultured with GH3 cells
Jeong et al., Bioconjug Chem 2010 : Upon activation of NFkappaB by interleukin-1beta (IL-1beta) , most of the plasmid distributed in the cytoplasm was localized within the nucleus, resulting in significantly higher gene transfection efficiency than controls with nondegradable PEI
Parcellier et al., Mol Cell Biol 2003 : HSP27 overexpression increases NF-kappaB nuclear relocalization, DNA binding, and transcriptional activity induced by etoposide, TNF-alpha, and interleukin 1beta
Sokol et al., Proc Natl Acad Sci U S A 2008 (Colitis...) : In Caco-2 cells transfected with a reporter gene for NF-kappaB activity, F. prausnitzii had no effect on IL-1beta induced NF-kappaB activity, whereas the supernatant abolished it
Ferlito et al., J Leukoc Biol 2001 (Leukemia, Monocytic, Acute...) : In naive cells, LPS, TNF-alpha, and IL-1beta induced IkappaBalpha degradation, kinase phosphorylation, and NF-kappaB DNA binding
Katsuyama et al., J Biochem 2001 : Gel shift assay and an immunocytochemical study showed that N2733 inhibited IL-1beta induced NF-kappaB activation and its nuclear translocation ... Our results suggest that the inhibitory action of N2733 toward IL-1beta induced NF-kappaB activation and iNOS expression is due to its blockade of the upstream signal ( s ) leading to IKK-alpha activation, and subsequent phosphorylation and degradation of IkappaB-alpha in rat VSMCs
Russo et al., Am J Physiol Cell Physiol 2002 : Differential requirement for NF-kappaB inducing kinase in the induction of NF-kappaB by IL-1beta , TNF-alpha, and Fas
Lim et al., Biol Reprod 2013 (Inflammation...) : As expected, IL1B induced NFKB transcriptional activity
Zaiss et al., J Immunol 2009 (Adenoviridae Infections) : In direct correlation with the increased viral internalization, antiviral Abs amplified the innate immune response to adenovirus as determined by the expression of NF-kappaB dependent genes, type I IFNs, and caspase dependent IL-1beta maturation
Kanda et al., Endocrinology 2008 : IL-1beta enhanced the transcriptional activity of NF-kappaB , whereas leptin enhanced STAT1 and STAT3 activity ... The p38 MAPK inhibitor SB202190 suppressed IL-1beta- and IL-1beta plus leptin induced hBD-2 production, IL-1beta induced NF-kappaB activity, and leptin induced STAT1 and STAT3 activity ; contrastingly, the Janus kinase (JAK) 2 inhibitor AG490 suppressed IL-1beta plus leptin induced hBD-2 production and leptin induced STAT1 and STAT3 activity ... IL-1beta or leptin individually induced threonine/tyrosine phosphorylation of p38 MAPK, whereas only leptin induced tyrosine phosphorylation of JAK2, suggesting that leptin may enhance hBD-2 production in keratinocytes by activating STAT1 and STAT3 via JAK2 and p38 MAPK in cooperation with NF-kappaB , which is activated by IL-1beta
O'Gorman et al., Cell Immunol 2005 : Signal transduction studies revealed that IL-1beta and TNF-alpha stimulation induced NFkappaB phosphorylation in A549 cells, but antagonist inhibition of NFkappaB p50-p65 phosphorylation correlated with marked reduction of IL-1beta or TNF-alpha induced CCL28 expression
Liu et al., Cancer Res 2003 (Colonic Neoplasms) : Electrophoretic mobility shift assay on nuclear extracts demonstrated that IL-1 beta induced NF-kappa B DNA binding activity in HT-29 cells, and the activated NF-kappa B complex was eliminated after treatment with an inhibitor of NF-kappa B ... Supershift assay indicated that the two NF-kappa B subunits, p65 and p50, were involved in activation of NF-kappa B complex by IL-1 beta stimulation
Chao et al., Neuroreport 1997 : In the present study using primary human fetal astrocyte cultures, we found that IL-1 beta stimulated activation of nuclear factor kappa B (NF-kappa B) within 2 h, iNOS mRNA expression at 8 h, and maximal NO production by 5 days post-treatment
Farley et al., J Invest Dermatol 2006 (Dermatitis...) : In HaCaT cells and in reconstructed human epidermis ( RHE ), FasL triggered a NF-kappaB dependent mRNA accumulation of inflammatory cytokines ( tumor necrosis factor-alpha, IL-6, and IL-1beta ), chemokines ( CCL2/MCP-1, CXCL1/GROalpha, CXCL3/GROgamma, and CXCL8/IL-8 ), and the adhesion molecule ICAM-1
Tozawa et al., Cancer Res 1995 (Neoplasm Metastasis) : Here we demonstrate that IL-1 beta induces nuclear translocation of NF kappa B in human umbilical vein endothelial cells, followed by induction of cell surface expression of E-selectin, intercellular adhesion molecule-1, and vascular adhesion molecule 1, and subsequently augments adhesion of those cancer cells expressing sialyl Lewis X antigen, a ligand to E-selectin
Druilhe et al., Cell Death Differ 2001 : Our data suggest that Pseudo-ICE and ICEBERG are intracellular regulators of caspase-1 activation and could play a role in the regulation of IL-1beta secretion and NF-kappaB activation during the pro-inflammatory cytokine response
Jang et al., Biochem Biophys Res Commun 2004 (Adenocarcinoma) : Interestingly, IL-1beta induced nuclear factor-kappaB (NF-kappaB) activation in A549 cells, which was shown by increased nuclear translocation of p65 NF-kappaB and degradation of IkappaB-alpha ... Specifically, IL-1beta induced nuclear translocation of NF-kappaB was in part attenuated by LY294002, but not by GF109203X, SB203580, and SP600125, suggesting PI3K dependent nuclear translocation of NF-kappaB in response to IL-1beta
Díaz-Cazorla et al., J Am Soc Nephrol 1999 : Treatment with N ( G ) -nitro-L-arginine methyl ester ( L-NAME ) did not affect initial activation of NF-kappaB by IL-1beta/TNF-alpha , but unveiled an inhibitory effect of NO generation on NF-kappaB activity after 4 h
Guo et al., Free Radic Biol Med 2008 : Avenanthramides, polyphenols from oats, inhibit IL-1beta induced NF-kappaB activation in endothelial cells
Russo et al., Cell Signal 2004 : Despite similar 125I-IL-1beta binding, HT-29 cells displayed no IRAK degradation, a 75 % reduction of IKK activity, and decreased IkappaBalpha phosphorylation, NF-kappaB DNA binding activity and IL-8 mRNA accumulation in response to IL-1beta compared to Caco-2 cells
Lee et al., J Immunol 2003 : IL-1 beta increased NF-kappa B and AP-1 activity and both transcription factors mediated IL-1 beta induced MCP-1 expression in mesangial cells ... In contrast, IL-1 beta induced NF-kappa B activity and I kappa B alpha degradation were not affected by BMP-7
Offermann et al., Eur J Biochem 1995 : NF-kappa B is also activated by IL-1 beta in HUVE cells, but this activation occurs without increased PKR autophosphorylation or eIF2 alpha phosphorylation
Patel et al., J Interferon Cytokine Res 2002 (Melanoma) : Treatment of melanoma cells with capsaicin inhibited activation of constitutive and IL-1beta induced NF-kappaB , but not AP-1, leading to inhibition of IL-8 expression
Kondo et al., Invest Ophthalmol Vis Sci 2008 (Corneal Ulcer...) : In contrast to dexamethasone, TPCA-1 inhibited the phosphorylation and degradation of IkappaBalpha and the nuclear translocation of NF-kappaB induced by IL-1beta
Jiang et al., Arterioscler Thromb Vasc Biol 2002 (MAP Kinase Signaling System) : However, either PDGF or EGF markedly enhanced interleukin-1beta induced persistent NF-kappaB activation and iNOS expression but did not affect the early and transient NF-kappaB activation ... Inhibition of ERK phosphorylation with selective inhibitors ( PD98059 or U0126 ) attenuated interleukin-1beta induced persistent NF-kappaB activation and iNOS expression in either the absence or presence of the growth factors
Newton et al., Eur J Biochem 1998 (Inflammation) : Effect of dexamethasone on interleukin-1beta-(IL-1beta) induced nuclear factor-kappaB (NF-kappaB) and kappaB dependent transcription in epithelial cells ... Similarly, BEAS-2B cells showed no effect of dexamethasone on IL-1beta induced NF-kappaB ( p50/p65 )
Jeong et al., Biochem Biophys Res Commun 2006 : IL-1Beta activated the extracellular signal regulated kinase 1/2 ( ERK1/2 ), and this activation was also enhanced by H ( 2 ) S. Inhibition of ERK1/2 activation by the selective inhibitor U0126 inhibited IL-1beta induced NF-kappaB activation, iNOS expression, and NO production either in the absence or presence of H ( 2 ) S ... Our findings suggest that H ( 2 ) S enhances NO production and iNOS expression by potentiating IL-1beta induced NF-kappaB activation through a mechanism involving ERK1/2 signaling cascade in rat VSMCs
Safronova et al., Inflamm Res 2003 (Anoxia...) : The analysis of IkappaB degradation and NF-kappaB translocation revealed that hypoxia did not affect IL-1beta activation of NF-kappaB
Masamune et al., Pancreas 2002 (Acute Disease...) : IL-1 beta and TNF-alpha increased the nuclear factor-kappa B (NF-kappa B)-specific and activator protein-1-specific DNA binding activity, whereas the NF-IL6 activity was not altered
Kreydiyyeh et al., Pflugers Arch 2004 : The activation of NF-kappaB by IL-1beta was maximal at 20 min and declined thereafter ... The effects of IL-1beta on the pump and NF-kappaB were prevented by the COX inhibitor indomethacin
Souza et al., J Endocrinol 2008 : Interestingly, the anti-inflammatory cytokines IL-4, IL-13 and IL-10 decreased IL-1beta stimulated NFkappaB activation and iNOS expression
Chen et al., J Biol Chem 2002 : In this study, we show the roles that CaMKK and Akt play in regulating interleukin-1beta (IL-1beta) induced NF-kappaB signaling ... In human embryonic kidney 293 cells, IL-1beta induces IkappaB kinase beta (IKKbeta) activation, IkappaBalpha degradation, NF-kappaB transactivation, and weak Akt activation ... A CaMKK inhibitor ( KN-93 ) and phosphatidylinositol 3-kinase inhibitors ( wortmannin and LY294002 ) do not inhibit IL-1beta induced NF-kappaB activation ... However, IL-1beta induced NF-kappaB activity is attenuated by increased intracellular calcium in response to ionomycin, UTP, or thapsigargin or by overexpression of CaMKKc and/or Akt ... We have also identified a novel interaction between CaMKK stimulated Akt and interleukin-1 receptor associated kinase 1 ( IRAK1 ), which plays a key role in IL-1beta induced NF-kappaB activation ... CaMKKc and Akt overexpression decreases IRAK1 mediated NF-kappaB activity and its association with MyD88 in response to IL-1beta stimulation ... Taken together, these results indicate a novel regulatory mechanism for IL-1beta signaling and suggest that CaMKK dependent Akt activation inhibits IL-1beta induced NF-kappaB activation through interference with the coupling of IRAK1 to MyD88
Kim et al., Mol Pharmacol 2008 (Inflammation...) : BOT-64 attenuates NF-kappaB regulated expression of inflammatory genes such as inducible nitric-oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha, interleukin (IL)-1beta , and IL-6 in LPS activated or expression vector IKKbeta transfected macrophages
Elmali et al., Inflammation 2007 (Arthritis, Experimental...) : Resveratrol, a polyphenolic, natural phytoalexin found with particularly high levels in grape skin and red wine is potent and specific inhibitor of TNF-alpha and IL-1beta induced NF-kappaB activation
Pahan et al., J Biol Chem 1999 : In contrast to the inability of LPS and IL-1beta alone to induce the expression of iNOS, both LPS and IL-1beta individually stimulated MAP kinase activity and induced DNA binding and transcriptional activity of NF-kappaB ... Moreover, wortmannin had no effect on LPS- or IL-1beta mediated activation of MAP kinase and NF-kappaB , suggesting that wortmannin induced the expression of iNOS in LPS- or IL-1beta stimulated C6 glial cells without modulating the activation of MAP kinase and NF-kappaB
Estrov et al., Blood 2003 (Acute Disease...) : Resveratrol blocks interleukin-1beta induced activation of the nuclear transcription factor NF-kappaB , inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells ... It also suppressed the IL-1beta induced activation of transcription factor nuclear factor kappaB (NF-kappaB) , which modulates an array of signals controlling cellular survival, proliferation, and cytokine production
Walsh et al., Shock 2008 : IL-1beta causes nuclear accumulation of NF-kappaB ( Rel A ) but does not increase nuclear IkappaBalpha
Yamasaki et al., Clin Exp Immunol 2002 (Arthritis, Rheumatoid) : Electrophoretic mobility shift assay ( EMSA ) showed a significant reduction in the DNA binding activity of NF-kappaB in troglitazone treated FLS in response to TNF-alpha or IL-1beta
Kaneda et al., Biomaterials 2009 : Cx43 liposomes containing a soluble NEMO binding domain peptide suppressed the intracellular signaling cascade IL-1beta induced NF-kappaB activation and cyclooxygenase-2 expression in Cx43 expressing cells, confirming effective peptide transfer into the cell
Kuang et al., Am J Physiol Cell Physiol 2002 : NF-kappaB induced by IL-1beta inhibits elastin transcription and myofibroblast phenotype ... These results indicate that IL-1beta activates the nuclear localization of NF-kappaB that subsequently interacts with Sp1 to downregulate elastin transcription and expression of the myofibroblast phenotype
Ahn et al., J Biol Chem 2007 : Besides TNF, gamma-tocotrienol also abolished NF-kappaB activation induced by phorbol myristate acetate, okadaic acid, lipopolysaccharide, cigarette smoke, interleukin-1beta , and epidermal growth factor
Stuhlmeier , J Immunol 2007 (Necrosis) : EMSAs demonstrate that neither BV nor melittin blocked IL-1beta induced NF-kappaB activation ; neither did they affect phosphorylation or degradation of IkappaB
Pena et al., Infect Immun 2009 : PAK DeltafliC also inhibited NF-kappaB induced by IL-1beta and Toll-like receptor 2 agonist Pam3CSK4
Son et al., Mol Cells 2005 : It also inhibited NF-IL6- and NF-kappaB induced activation of IL-1beta , with IC50 values of 78 nM and 1.6 microM, respectively, revealing a potent inhibitory effect on NF-IL6
Liang et al., J Cell Physiol 2007 (MAP Kinase Signaling System) : Furthermore, IL-1beta stimulated translocation of NF-kappaB into the nucleus and degradation of IkappaB-alpha was blocked by helenalin
Bergmann et al., J Biol Chem 1998 : Two closely related IkappaBalpha kinases as well as the upstream kinase, NIK, which integrates interleukin-1beta (IL-1beta)- and tumor necrosis factor (TNF)-alpha dependent activation of the transcription factor NF-kappaB have recently been described ... However, IL-1beta induced IkappaBalpha degradation as well as NF-kappaB nuclear translocation and DNA binding, as determined by Western blot and electro-mobility shift assay, respectively, are not affected by these inhibitors
Nakao et al., Mol Cell Biochem 2000 : Since pro-inflammatory cytokine IL-1beta has been shown to induce prostaglandin E2 ( PGE2 ) release in human gingival fibroblasts (HGF), here we analyzed the effect of IL-1beta on the expression of COX-2 and the activation of NFkappaB in HGF
Nomura et al., Nihon Yakurigaku Zasshi 1999 (Glioma...) : We also found in IL-1 beta induced CINC expression using cultured C6 glioma cells, the transient translocation of NF-kappa B in response to IL-1 beta is partly dependent on transient proteasome activation
Wang et al., Prostaglandins Leukot Essent Fatty Acids 1998 : These results provide convincing evidence that NF-kB may mediate the IL-1beta stimulation of PGHS-2 gene expression as well as the dexamethasone inhibition of the IL-1beta induction process in WISH cells
Jie Zhao et al., Innate Immun 2009 (Aspergillosis...) : In addition, the A. fumigatus antigens induced production of IL-1beta and IL-10 in supernatants of corneal epithelial cells was also attenuated by NF-kappaB inhibitor
Kim et al., Biochem Pharmacol 2004 : Epicatechin significantly reduced IL-1beta induced nitrite production, iNOS protein and mRNA expressions, and it also inhibited IL-1beta induced IkappaBalpha protein degradation, NF-kappaB activation , and iNOS promoter activity
Ho et al., Biochem Pharmacol 2007 : Inhibitory effect on IL-1beta mediated NF-kappaB activation was evidenced by the diminishment of IkappaB kinase (IKK) phosphorylation and IkappaBalpha degradation
Lu et al., Proc Natl Acad Sci U S A 2007 : Similarly high concentrations of each of these cytokines cross-activate the other pathway : TGFbeta activates NFkappaB , and IL-1beta activates Smads
Grall et al., Arthritis Rheum 2003 (Arthritis, Rheumatoid...) : Transient transfection experiments and EMSAs showed that induction of ESE-1 gene expression by IL-1beta requires activation of NF-kappaB and binding of p50 and p65 family members to the NF-kappaB site in the ESE-1 promoter
Yuan et al., Eur J Pharmacol 2009 (Inflammation...) : Ghrelin also significantly suppressed interleukin-1beta , tumor necrosis factor-alpha, and endothelin-l mRNA expression, and inhibited NF-kappaB activation
Yamamoto et al., J Hypertens 2005 : Interleukin-1beta induced NF-kappaB activation in vascular smooth muscle cells, and the addition of GGA further inhibited this NF-kappaB activation
Clemens et al., Brain Res Mol Brain Res 1997 (Brain Ischemia) : The oxidative stress responsive transcription factor nuclear factor-kappa B (NF-kappa B) consists of a p50 ( 50 kDa ) and p65/RelA ( 65 kDa ) component and can be activated in vitro by TNF alpha, IL1 beta , hydrogen peroxide and oxygen radicals
Liu et al., Mol Cell Biol Res Commun 2001 (MAP Kinase Signaling System) : While the Raf-1 activation induces a modest IkappaB degradation by enhancing the basal IkappaB kinase activity, it contradictorily suppresses the proinflammatory cytokine inducible IkappaB kinase complex, leading to an inhibition of TNF-alpha- and IL-1beta induced NF-kappaB activation
Bonizzi et al., Biochem Pharmacol 1999 : The PKC inhibitor calphostin C inhibited NF-kappaB activation by tumor necrosis factor (TNF)-alpha or interleukin (IL)-1beta in Jurkat or NIH3T3 cells but not in MCF7 A/Z cells
Reed et al., Dig Dis Sci 2005 (Colitis...) : Colon tissue was collected for assessment of histological changes, NF-kappa B activation , myeloperoxidase (MPO) activity, and expression of NK-1R, SP, TNFalpha, IL-1beta , VCAM-1, ICAM-1, E-selectin, CINC-1, MIP-1alpha, and iNOS
Wright et al., Am J Physiol Heart Circ Physiol 2002 : However, interleukin-1beta and phorbol 12-myristate 13-acetate also activated NF-kappaB but did not evoke TNF-alpha expression, revealing that this factor is not sufficient for cytokine production
Kwon et al., Nitric Oxide 2001 : We found that both IL-1beta and TNF-alpha could independently activate cytosolic NF-kappaB , direct its translocation into the nucleus, and induce iNOS monomer synthesis
Callister et al., Br J Pharmacol 2008 : PMX464 inhibited IL-1beta induced NF-kappaB DNA binding, nuclear translocation of NF-kappaB p65 subunit and factors involved in NF-kappaB activation ; specifically, IkappaBalpha degradation, IkappaB phosphorylation and IkappaB kinase (IKK) activity in A549
Noh et al., Rheumatology (Oxford) 2009 (Arthritis, Rheumatoid...) : Moreover, cordycepin significantly inhibited IL-1beta induced p38/JNK and AP-1 activation, but not extracellular signal regulated kinase ( ERK ) and NF-kappaB activation
Wehling et al., Arthritis Rheum 2009 : Matrix metalloproteinase 13 was induced by IL-1beta in a NF-kappaB dependent manner
Jang et al., FEMS Immunol Med Microbiol 2007 : However, although Dex did not inhibit the nuclear translocation of p65 NF-kappaB in response to IL-1beta , it profoundly inhibited NF-kappaB promoter- and HBD-2 promoter-driven luciferase activities
Migita et al., Rheumatology (Oxford) 2005 : A77 1726 inhibited IL-1beta induced p38 and c-Jun N-terminal kinase 1/2 ( JNK1/2 ) activation, whereas A77 1726 did not affect IL-1beta induced NF-kappaB activation in hepatocytes
Lu et al., Invest Ophthalmol Vis Sci 2005 : The activation of NF-kappaB by IL-1beta was markedly inhibited by both triptolide and dexamethasone, whereas the activity of AP-1 was not affected by either agent
Vuolteenaho et al., Scand J Rheumatol 2005 (Osteoarthritis, Knee) : This can be explained by the fact that the four effective DMARDs also suppressed IL-1beta induced activation of nuclear factor kappa B (NF-kappaB) , which is a crucial transcription factor for iNOS
Heimberg et al., Diabetes 2001 : The transcription factor nuclear factor-kappaB (NF-kappaB) is activated by interleukin-1beta (IL-1beta) , and its activity promotes the expression of several beta-cell genes, including pro- and anti-apoptotic genes
de Mejia et al., Peptides 2009 (Inflammation) : The 5 kDa peptide inhibited most potently pro-inflammatory markers including interleukin-6 production ( IC ( 50 ) =2 microM ), interleukin-1beta production ( IC ( 50 ) =13 microM ), nuclear factor-kappa B (NF-kappaB) transactivation ( IC ( 50 ) =21 microM ), cyclooxygenase-2 expression ( IC ( 50 ) =25 microM ), nitric oxide production ( IC ( 50 ) =28 microM ), inducible nitric oxide synthase expression ( IC ( 50 ) =37 microM ), prostaglandin E ( 2 ) production ( IC ( 50 ) =41 microM ), p65 nuclear translocation ( IC ( 50 ) =48 microM ) and p50 nuclear translocation ( IC ( 50 ) =77 microM )
Dasgupta et al., J Neurosci Res 2009 : A thorough screening of the signaling system confirmed that TNFalpha/IL-1beta stimulation up-regulated nuclear factor kappaB (NFkappaB) signaling in SV-HCECs
Shultz et al., J Interferon Cytokine Res 2009 : IFN-gamma does not affect the transient activation of classical NF-kappaB by IL-1beta and synergistic induction of ip-10 expression by IFN-gamma and IL-1beta occurs even after the activation of classical NF-kappaB has returned to basal levels
Cogswell et al., J Immunol 1994 : NF-kappa B regulates IL-1 beta transcription through a consensus NF-kappa B binding site and a nonconsensus CRE-like site
Pan et al., J Immunol 1998 : The role of NF-kappaB activation in BK-induced IL-1beta synthesis was demonstrated by the ability of BK to stimulate increased chloramphenicol acetyltransferase (CAT) activity in A549 cells transfected with a reporter plasmid containing three kappaB enhancers from the IL-1beta gene, while deletion of the kappaB enhancer sequences eliminated BK-stimulated CAT activity ... C3 transferase exoenzyme, an inhibitor of Rho, abolished BK-induced NF-kappaB activation at 10 microg/ml and significantly inhibited BK-stimulated IL-1beta synthesis at 5 microg/ml
Hastings et al., Arterioscler Thromb Vasc Biol 2009 (Atherosclerosis) : Neutralization of the IL-8 receptor, CXCR2, further induced VCAM-1 in the presence of IL-1beta , and phospho-p38 was required for NF-kappaB activation and VCAM-1 expression ... Additionally, IL-8 reduced p38 activation and NF-kappaB activity induced by IL-1beta alone
Nadjar et al., J Cereb Blood Flow Metab 2005 (Brain Neoplasms...) : Incubation of rat glioma cells with the NBD peptide blocked IL-1beta induced NFkappaB nuclear translocation ... Treatment with NBD peptide completely abolished IL-1beta induced NFkappaB activation and Cox-2 synthesis in microvasculature ... These findings strongly support the hypothesis that IL-1beta induced NFkappaB activation plays a major role in transmission of immune signals from the periphery to the brain
Domagala et al., Biorheology 2006 : Inhibition of interleukin-1beta induced activation of MEK/ERK pathway and DNA binding of NF-kappaB and AP-1 : potential mechanism for Diacerein effects in osteoarthritis
Allport et al., Mol Hum Reprod 2001 : In cells obtained before labour, in which NF-kappaB activity is low, increasing the concentration of PR represses NF-kappaB dependent transcription, while stimulation with IL-1beta both increases NF-kappaB activity and represses PR activity
Guo et al., Blood 2003 : Inhibiting NF-kappaB did not affect either IL-1beta secretion or phenotypic maturation but rather sensitized DCs to Fas mediated apoptosis
Estrov et al., Blood 1999 (Acute Disease...) : Phenylarsine oxide blocks interleukin-1beta induced activation of the nuclear transcription factor NF-kappaB , inhibits proliferation, and induces apoptosis of acute myelogenous leukemia cells ... Because PAO inhibits activation of the transcription factor NF-kappaB and because NF-kappaB modulates an array of signals controlling cellular survival, proliferation, and cytokine production, we also studied the effect of PAO on NF-kappaB activation in AML cells and found that PAO suppressed the IL-1beta induced activation of NF-kappaB
Li , J Pharmacol Sci 2003 (Bacterial Infections...) : Among those signaling pathways, activation of NF-kappaB leads to up-regulation of IL-1beta , IL-8 and TNF-alpha, mucin MUC2 and Toll-like receptor 2 (TLR2), whereas activation of p38 MAP kinase mediates not only up-regulation of inflammatory mediators and mucin MUC5AC but also down-regulation of TLR2
Wang et al., Invest Ophthalmol Vis Sci 1999 : TNF-alpha, IL-1beta , and TII but not IFN-gamma alone caused degradation of I kappaB, Rel A nuclear translocation, and increased NF-kappaB DNA binding activity, effects that were blocked by pretreatment with MG-132
Lin et al., Mol Pharmacol 2000 : IL-1beta caused the translocation of p65 NF-kappaB from cytosol to the nucleus as well as the degradation of IkappaB-alpha in cytosol
Lee et al., Proc Natl Acad Sci U S A 2004 (Fever...) : Whereas IL-1beta induced the expression of the NF-kappaB-reporter gene and was suppressed by competitive inhibition of NF-kappaB binding, IL-18 responses were weak or absent
Beck et al., FEBS Lett 1996 : We found that binding of NFkappaB is strongly induced in mesangial cells by both IL-1beta and TNF-alpha
Busik et al., Diabetes 2008 (Diabetic Retinopathy...) : Exposure of HRECs to 25 mmol/l glucose did not stimulate endogenous ROS production, activation of nuclear factor-kappaB (NF-kappaB) , extracellular signal related kinase ( ERK ), p38 and Jun NH ( 2 ) -terminal kinase ( JNK ), tyrosine phosphorylation, interleukin (IL)-1beta , or tumor necrosis factor-alpha (TNF-alpha) production and only slightly affected apoptotic cell death pathways compared with normal glucose ( 5 mmol/l )
Yotsui et al., FEBS Lett 2007 (Atherosclerosis) : Nuclear factor kappaB (NF-kappaB) activity was enhanced by IL-1beta and reduced by aspirin, indicating that decreased ICAM-1 and VCAM-1 expression was due to reduced NF-kappaB activity.Thus, aspirin inhibits the adhesion of Jurkat T cells to IL-1beta activated AoSMC by reducing NF-kappaB activity and decreasing expression of ICAM-1 and VCAM-1, and may prevent the development of atherosclerosis
Pingle et al., Mol Pharmacol 2003 : Both of these agents also reduced the activation of NF-kappaB induced by LPS, tumor necrosis factor-alpha and interleukin-1beta in smooth muscle cells
Ali et al., FEBS Lett 1999 (Bone Resorption) : Using electrophoretic mobility shift assays, we found that not only tumour necrosis factor-alpha (TNF-alpha) but also interleukin-1beta and parathyroid hormone (PTH) caused dose and time related increases in nuclear factor kappaB (NF-kappaB)-DNA binding in Saos-2 human osteoblastic ( hOB ) cells
Yu et al., Br J Nutr 2007 : In the present study, we investigated the effects of EA on the formation of intracellular reactive oxygen species, the translocation of NFkappaB and expression of vascular cell adhesion molecule-1 ( VCAM-1 ), intercellular adhesion molecule-1 and endothelial leucocyte adhesion molecule ( E-selectin ) induced by IL-1beta in human umbilical vein endothelial cells ( HUVEC )
Chen et al., J Cell Biochem 2003 : Our results suggest that NF-kappaB activation in PIMs followed by phagocytizing lipopolysaccharide resulted in the up-regulation of TNF-alpha, IL-1beta , IL-6, IL-8, and COX-2, which could be alleviated by dexamethasone
Yang et al., Life Sci 2002 : Treatment of cells with sphondin ( 50 microM ) or the NF-kappaB inhibitor, PDTC ( 50 microM ) partially inhibited IL-1beta induced degradation of IkappaB-alpha in the cytosol and translocation of p65 NF-kappaB from the cytosol to the nucleus ... Furthermore, IL-1beta induced NF-kappaB-specific DNA-protein complex formation in the nucleus was partially inhibited by sphondin ( 50 microM ) or PDTC ( 50 microM )
Harcourt et al., J Virol 1999 (Hemorrhagic Fever, Ebola) : In contrast, infection with EZ did not block activation of the transcription factor NF-kappaB by IL-1beta
Kusunoki et al., Arthritis Rheum 2010 (Arthritis, Rheumatoid) : Enhancement of NF-kappaB activation by adiponectin as well as by interleukin-1beta was observed in RASFs
Nakajima et al., Neurosci Lett 2006 : Taken together, these results suggest that the induction of IL-1beta and TNFalpha in endotoxin stimulated microglia is differentially regulated at the level of NFkappaB activation
Layé et al., FEBS Lett 1998 : Human/mouse interleukin-1 receptor/receptor accessory protein interactions in IL-1beta induced NFkappaB activation
Gao et al., Cell Mol Life Sci 2009 : Transforming growth factor-beta activated kinase 1 ( TAK1 ) is a serine/threonine protein kinase that is critically involved in the activation of NF-kappaB by tumor necrosis factor ( TNFalpha ), interleukin-1beta (IL-1beta) and TLR ligands
Lin et al., J Pharmacol Exp Ther 2007 (Neuroblastoma) : GLNVA also reduced cyclooxygenase (COX)-2 expression, inhibitor of nuclear factor (NF)-kappaB ( IkappaB)alpha/IkappaBbeta degradation, NF-kappaB activation , and the overproduction of tumor necrosis factor-alpha, interleukin (IL)-1beta , and prostaglandin E2 in BV-2 cells
Jomphe et al., Basic Clin Pharmacol Toxicol 2008 : Chondroitin sulfate reduced IL-1beta induced NF-kappaB nuclear translocation, but not AP-1 translocation, it decreased IL-1beta induced phosphorylation of Erk1/2 and abrogated p38MAPK phosphorylation, but did not prevent IL-1beta induced increase in nitrite
Stanimirovic et al., J Neuroimmunol 2001 (Hypoxia, Brain) : The data suggest that hypoxia/reoxygenation induced up-regulation of IL-1beta and IL-8 in human astrocytes has two components, a NF-kappaB independent up-regulation during hypoxia, followed by amplification through autocrine IL-1beta induced NF-kappaB activation during reoxygenation
Hwang et al., Oncogene 2004 (Stomach Neoplasms) : Electrophoretic mobility shift assay confirmed that IL-1beta increased the DNA binding activity of AP-1 and NF-kappaB
Valles et al., Alcohol Clin Exp Res 2003 : Stimulation of hepatocytes with IL-1beta caused a higher activation of IL-1 associated kinase, extracellular receptor activated kinases 1 and 2, and nuclear factor-kappaB (NF-kappaB) in hepatocytes from alcohol fed animals than from controls ... Our results suggest the participation of the extracellular signal regulated kinase ( ERK ) 1/2 pathway in ethanol induced NF-kappaB activation, because treatment with PD-98059, an ERK1/2 inhibitor, partially suppressed IL-1beta induced NF-kappaB expression
Lee et al., Mol Cells 2003 : Astaxanthin also suppressed the serum levels of NO, PGE2, TNF-alpha, and IL-1beta in LPS administrated mice, and inhibited NF-kappaB activation as well as iNOS promoter activity in RAW264.7 cells stimulated with LPS
Hagood et al., Am J Respir Cell Mol Biol 2002 : IL-1beta induces DNA binding of both nuclear factor kappaB (NF-kappaB) and CAATT-enhancer binding protein (C/EBP), and activation of p38 mitogen activated protein kinase in both subpopulations
Lambert et al., J Bone Miner Res 2007 : In contrast, NF-kappaB was not essential for IL-1beta induction of OPG
Norman et al., Cardiovasc Res 1998 : Nuclear factor NF-kappa B in myocardium : developmental expression of subunits and activation by interleukin-1 beta in cardiac myocytes in vitro
Campo et al., Biofactors 2012 (Inflammation) : IL-1beta stimulation significantly up-regulated HA levels, its fragmentation, cAMP, PKA, cytokine levels, and activated NF-kB
Fisher et al., Gene Ther 2004 : The ability of the transport peptide-PNA-NFkappaB decoy complex to block the effect of interleukin (IL)-1beta induced NFkappaB activation and IL-6 gene expression was analyzed by electrophoretic mobility shift assay and reverse transcriptase-polymerase chain reaction in rat Rinm5F insulinoma cells ... Preincubation with transport peptide-PNA-NFkappaB decoy ( 1 microM, 1 h ) blocked IL-1beta induced NFkappaB binding activity and significantly reduced the IL-6 mRNA expression
Thommesen et al., J Immunol 1998 : Activation of NF-kappaB by IL-1beta was markedly less sensitive to both cPLA2 and sPLA2 inhibitors
He et al., Zhonghua Yi Xue Za Zhi 2001 (Pulmonary Disease, Chronic Obstructive) : Enhancement of activity of NF kappa B and AP-1 may positively regulate the production of IL-8 and IL-1 beta in the airflow obstruction
Agarwal et al., Arthritis Rheum 2004 (Arthritis) : CTS of low magnitudes ( 4-8 % equibiaxial strain ) was a potent inhibitor of IL-1beta dependent NF-kappaB nuclear translocation
Lukita-Atmadja et al., Shock 2002 (Endotoxemia...) : Curcuminoids, derived from the plant Curcuma domestica Val., have been shown to be free radical scavengers that suppress the production of superoxide by macrophages and potent anti-inflammatory agents that inhibit the lipopolysacharide (LPS) induced production of tumor necrosis factor alpha (TNFalpha), interleukin (IL)-1beta , and the activation of nuclear factor (NF)-kappaB in human monocytic derived cells
Debret et al., J Invest Dermatol 2006 (MAP Kinase Signaling System...) : Concomitantly, we demonstrated that EFs stimulation induced NF-kappaB nuclear translocation and DNA binding on IL-1beta promoter region whereas inhibition of NF-kappaB with the specific chemical inhibitor SN-50 or by overexpression of IkappaB, the endogenous inhibitor of NF-kappaB pathway, totally abolished EFs mediated IL-1beta mRNA overexpression
Condon et al., Proc Natl Acad Sci U S A 2004 : Expression of IL-1beta in AF macrophages and activation of NF-kappaB in the maternal uterus increased with the gestational increase in SP-A ... We propose that augmented production of SP-A by the fetal lung near term causes activation and migration of fetal AF macrophages to the maternal uterus, where increased production of IL-1beta activates NF-kappaB , leading to labor
Pinteaux et al., J Neurochem 2002 : Bacterial lipopolysaccharide (LPS) caused increased expression of IL-1RI, IL-1RII and IL-1RAcP mRNAs, induced the release of IL-1beta , IL-6 and prostaglandin-E2 ( PGE2 ), and activated nuclear factor kappaB (NF-kappaB) and the mitogen activated protein kinases ( MAPKs ) p38, and extracellular signal regulated protein kinase ( ERK1/2 ), but not c-Jun N-terminal kinase (JNK) in microglial cultures ... In comparison, IL-1beta induced the release of PGE2, IL-6 and activated NF-kappaB , p38, JNK and ERK1/2 in mixed glial cultures, but failed to induce any of these responses in microglial cell cultures
Born et al., J Biol Chem 2000 : Neither receptor alone was able to mediate transcriptional activation of NF-kappaB in response to IL-1alpha, IL-1beta , or IL-18
Joo et al., Eur J Pharmacol 2009 (Colitis) : An anti-inflammatory mechanism of taurine conjugated 5-aminosalicylic acid against experimental colitis : taurine chloramine potentiates inhibitory effect of 5-aminosalicylic acid on IL-1beta mediated NFkappaB activation ... To explore a molecular mechanism for the anti-inflammatory property of the prodrug, we investigated the effect of the conjugate on IL-1beta mediated NFkappaB activation ... In HCT116 cells, the inhibitory effect by TauCl or 5-ASA was through preventing IL-1beta induced IkappaB kinase activation and subsequently interfering with IkappaBalpha degradation and p65 nuclear accumulation ... Furthermore, combined TauCl/5-ASA treatment interfered additively with the activation process, leading to additive inhibitory effect on IL-1beta mediated NFkappaB activation ... Our results suggest that the anti-inflammatory effect of the prodrug on experimental colitis is attributed to the inhibition of the IL-1beta mediated NFkappaB activation and the taurine effect is through TauCl potentiating the ability of 5-ASA to inhibit IL-1beta dependent NFkappaB activation
Masamune et al., J Cell Biochem 2006 : Curcumin inhibited interleukin-1beta- and TNF-alpha induced activation of activator protein-1 (AP-1) and mitogen activated protein ( MAP ) kinases ( ERK, c-Jun N-terminal kinase (JNK), and p38 MAP kinase ), but not of nuclear factor-kappaB (NF-kappaB)
Vykhovanets et al., Prostate 2009 (Inflammation...) : Concomitant administration of Dex, a known NF-kappaB inhibitor, resulted in significantly down-regulated IL-1 beta induced NF-kappaB/p65 activity, as well as reduced expression of chemokine receptors and IL-17F in mouse prostate tissue
Cooper et al., Biochem Pharmacol 2000 : We then investigated the effects of transfection of monocytes with these oligonucleotides on interleukin-1beta (IL-1beta) stimulated IL-8 production, IL-8 mRNA expression, and NF-kappaB binding activity ... This single stranded oligonucleotide also inhibited IL-1beta induced translocation of NF-kappaB to the nucleus and reduced IL-8 mRNA expression
Shen et al., Biochem J 2000 : However, pretreatment with the proteasome inhibitor MG132 under conditions that prevented the IL-1beta dependent activation of the nuclear factor NF-kappaB also blocked the inhibitory effect of IL-1beta on IL-6 activated STAT1 ... Taken together, these findings indicate that, by using a proteasome dependent mechanism, IL-1beta concomitantly induces NF-kappaB activation and dephosphorylates IL-6 activated STAT1 ; the latter might partly account for the inhibition by IL-1beta of the IL-6 dependent induction of type II acute-phase genes
Boost et al., BMC cancer 2008 (Lung Neoplasms...) : These observations concurred with lack of a modulatory activity of IFNgamma on IL-1beta induced NF-kappaB activation as assessed by cellular IkappaB levels
Sawano et al., Kidney Int 2002 : 15d-PGJ2 inhibited the IL-1beta induced increase in binding activities of nuclear proteins to consensus AP-1 site and AP-1-like site of COX-2 promoter but not of NF-kappaB
Shimizu et al., Mol Hum Reprod 2007 : However, inhibition of the RhoA/Rho-kinase pathway did not attenuate the activation of NF-kB by IL-1beta
Lafarge et al., BMC molecular biology 2007 : In response to IL1beta , or IL10, the levels of phosphorylated NF-kappaB and STAT3 -- respectively -- increased significantly for all the studied cell types
Agarwal et al., FASEB J 2003 : This leads to sustained suppression of IL-1beta induced NF-kappaB transcriptional regulation of proinflammatory genes
Wilson et al., Gastroenterology 1999 : In contrast, IL-1beta induced NF-kappaB activation was associated with the disappearance of IkappaBalpha and was inhibited by ALLN but not staurosporine
Chen et al., Am J Physiol Cell Physiol 2007 : ROS and NF-kappaB but not LXR mediate IL-1beta signaling for the downregulation of ATP binding cassette transporter A1
Shimada et al., J Pharmacol Exp Ther 1999 : NF-kappaB activation in response to TNF-alpha, IL-1beta , phorbol ester, and H ( 2 ) O ( 2 ) was down-regulated by polaprezinc
Bonizzi et al., J Immunol 1997 : Indeed, inhibition of receptor internalization as well as NH4Cl and chloroquine blocked IL-1beta mediated induction of NF-kappaB in OVCAR-3 and in other epithelial cell lines but not in lymphoid cells, indicating that distinct pathways are involved ... Moreover, expression of the 5-lipoxygenase (5-LOX) enzyme was not detected in epithelial cells, and inhibition of this enzyme blocked NF-kappaB induction by IL-1beta only in lymphoid cells
Ikeda et al., J Cardiovasc Pharmacol 2003 : Addition of IL-1beta activated nuclear factor-kappaB (NFkappaB) in VSMCs, whereas CRP did not affect IL-1beta induced NFkappaB activation
Li et al., Mol Cell Biol 2006 : Clearance of both superoxide and H2O2 from within the endosomal compartment significantly abrogated IL-1beta dependent IKK and NF-kappaB activation ... Small interfering RNAs to either MyD88 or Rac1 inhibited IL-1beta induction of endosomal superoxide and NF-kappaB activation
Larner-Svensson et al., Respir Res 2010 : We have shown that IL-1beta induced miR-146a expression in HASM and that this was regulated at the transcriptional level by NF-kappaB and at the post-transcriptional level by the MEK-1/2 and JNK-1/2
Sharma et al., J Appl Physiol 2001 : Constitutive and interleukin (IL)-1beta stimulated NF-kappaB activation was significantly greater ( P < 0.05 ) in VSM cells from aged compared with young female rats ... E2 treatment of VSM cells from aged female rats inhibited both constitutive and IL-1beta stimulated NF-kappaB activation ... In conclusion, our data demonstrate that constitutive and IL-1beta stimulated NF-kappaB activation is increased in VSM cells from aged female rats due to loss of E2 and this can be restored back to normal levels by ER-alpha gene transfer and E2 treatment
Sabolek et al., Stem Cells 2009 (MAP Kinase Signaling System) : Surprisingly, IL-1beta did not activate the NF-kappaB pathway or the transcription factor activating protein 1 (AP-1), but inhibition of nuclear translocation of NF-kappaB by SN50 facilitated IL-1beta induced Nurr1 expression and dopaminergic differentiation of mdNPCs
Parry et al., Arterioscler Thromb Vasc Biol 1998 : norLeu and TPCK also blocked IL-1beta induced MCP-1 promoter-driven reporter gene expression as well as nuclear factor (NF)-kappaB mediated reporter gene expression
Wei et al., Mol Pharmacol 2006 : In addition, fluvastatin increased IL-1beta induced p65 nuclear translocation and nuclear factor kappaB (NF-kappaB) activity, although it inhibited those induced by LPS ... We found that Y-27632 potentiated IL-1beta induced iNOS expression, p65 nuclear translocation, IkappaB kinase (IKK), and NF-kappaB activation, whereas it had minimal effects on LPS induced responses
Teng et al., Am J Physiol Cell Physiol 2002 : IL-1 beta , but not IFN-gamma, induced nuclear factor (NF)-kappa B and CCAAT box/enhancer binding protein ( C/EBP ) nuclear binding
Lee et al., Nephron 2002 : SIN-1 dose dependently inhibited the TNF-alpha- or IL-1beta induced NF-kappaB binding activity and suppressed the TNF-alpha induced degradation of IkappaB-alpha
Sehnert et al., Arthritis Res Ther 2006 : Concomitantly, ALP suppressed the IL-1beta induced NF-kappaB activation and the upregulation of E-selectin expression in glEND.2 cells in vitro
Martin et al., Arthritis Rheum 2004 (Anoxia) : IL-1beta induced DNA binding of NF-kappaB and AP-1 was significantly higher in hypoxic and reoxygenated cultures than in normoxia
Sunil et al., Int J Colorectal Dis 2010 : The influence of NFkappaB inhibitors ( dexamethasone, pyrrolidine dithiocarbamate ( PDTC ) and BAY 11-7082 ) on IL-1beta induced NFkappaB transcriptional activity was investigated by transient transfection of Caco-2 cells with an NFkappaB secreted alkaline phosphatase reporter plasmid
Swingler et al., Biochem Biophys Res Commun 1994 (Astrocytoma...) : In human astrocytoma and neuroblastoma cell lines tumour necrosis factor alpha (TNF alpha) and interleukin 1 beta (IL-1 beta) induced NFKB and an additional KB-specific protein of approximately 80 K to bind the HIV-1 enhancer
Marcheselli et al., J Biol Chem 2003 (Reperfusion Injury) : In addition, in neural cells in culture, this lipid messenger also inhibited both interleukin 1-beta induced NFkappaB activation and cyclooxygenase-2 expression
Inan et al., Mol Carcinog 2000 : The p106 and p112 proteins bound to NF-kappaB, and their levels changed during the transient interleukin-1beta activation of NF-kappaB in HT-29 cells
Kitagawa et al., Am J Physiol Gastrointest Liver Physiol 2004 : IL-1beta stimulated the degradation of IkappaB and the activation of NF-kappaB but had no effect on iNOS induction
Mancini et al., Neurosci Lett 2003 : These data indicate that therapeutic concentrations of acetaminophen induce an inhibition of IL-1beta dependent NF-kappaB nuclear translocation
Schroeder et al., Am J Physiol 1999 : On the basis of previous work demonstrating nitric oxide ( NO ) -mediated inhibition of nuclear factor-kappaB (NF-kappaB) DNA binding, we hypothesized that NO downregulates NF-kappaB dependent interleukin-1beta (IL-1beta) production in an ANA-1 macrophage model of lipopolysaccharide (LPS) stimulation
Okada et al., J Vet Med Sci 2010 : IL-1beta ( 4 ng/ml, 10 min ) induced phosphorylation of NF-kappaB , JNK, and ERK ... Angiotensin II augmented the IL-1beta induced phosphorylation of ERK but not NF-kappaB and JNK
Jeon et al., Immunopharmacology 2000 : Dexamethasone inhibits IL-1 beta gene expression in LPS stimulated RAW 264.7 cells by blocking NF-kappa B/Rel and AP-1 activation
Maliner-Stratton et al., Neoplasia (New York, N.Y.) 2001 (Adenocarcinoma...) : Inhibition of IL-6 activity attenuated IL-1beta induced promatrilysin, but not NFkappaB transactivation activity indicating that IL-6 acts downstream of NFkappaB in potentiation of IL-1beta mediated promatrilysin expression
Prickett et al., J Biol Chem 2008 : TAB4 mutated at Phe-Pro dominantly interfered with IL-1beta activation of NF-kappaB involving IKK dependent but not p38 MAPK dependent signaling
Yang et al., J Neuroimmunol 2008 : The activation of NF-kappaB was followed by increased mRNA expression of TNF-alpha and IL-1beta peaking at about 20 h
Zhang et al., Mol Biol Cell 2010 : PLK1 inhibits NF-kappaB transcriptional activation induced by TNF-alpha, IL-1beta , or several activators, but not by nuclear transcription factor p65
Koziczak-Holbro et al., Ernst Schering Foundation symposium proceedings 2007 : IRAK-4 KD cells were severely impaired in NF-kappaB , JNK, and p38 activation in response to IL-1beta or TLR7 ligand
Liang et al., Mol Hum Reprod 2008 : Since IL-1beta activates NFkappaB , AP-1 and C/EBP, we over expressed these transcription factors alone and in combination and found that only NFkappaB alone increased FP mRNA expression
Kabouridis et al., J Immunol 2002 (MAP Kinase Signaling System) : TAT-srIkappaBalpha, when exogenously added to HeLa cells, inhibited in a dose dependent manner TNF-alpha- or IL-1beta induced NF-kappaB activation and binding of NF-kappaB to its consensus DNA sequence
Jiang et al., J Biol Chem 2004 : Without ERK activation, interleukin-1beta induces only acute and transient NF-kappaB activation ... Thus, although NF-kappaB activation was essential for interleukin-1beta induction of each of the proteins studied, gene expression was differentially regulated by ERK and by the duration of NF-kappaB activation
Raymond et al., Osteoarthritis Cartilage 2007 (Arthritis) : RelA is required for IL-1beta stimulation of Matrix Metalloproteinase-1 expression in chondrocytes
Assenat et al., Hepatology 2004 (Carcinoma, Hepatocellular) : We demonstrate that : ( 1 ) LPSs, IL-1beta, or overexpression of p65RelA inhibit glucocorticoid receptor ( GR ) -mediated CAR transactivation ; ( 2 ) these suppressive effects can be blocked both by pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB activation, or by overexpression of SRIkBalpha, a NF-kappaB repressor ; and ( 3 ) the GR agonist dexamethasone induces histone H4 acetylation at the proximal CAR promoter region, whereas LPSs and IL-1beta inhibit this acetylation as assessed via chromatin immunoprecipitation assay
Galea et al., Neuroreport 2002 (Inflammation) : We report that 17beta-estradiol ( E ( 2 ) ), but not the alpha-enantiomer, inhibited the basal and interleukin-1beta (IL-1beta) mediated expression of the intercellular adhesion molecule type 1 ( ICAM1 ) and NFkappaB activation, in cultured brain endothelial cells
Lee et al., Journal of inflammation (London, England) 2010 : IL-1beta potently induced NF-kappaB activation in CaCo-2 cells, but did not induce TLR-4 expression
Loiarro et al., J Leukoc Biol 2007 (Chronic Disease...) : Moreover, ST2825 interfered with recruitment of IRAK1 and IRAK4 by MyD88, causing inhibition of IL-1beta mediated activation of NF-kappaB transcriptional activity
Zhang et al., J Biol Chem 2009 : Injury induced platelet derived growth factor receptor-alpha expression mediated by interleukin-1beta (IL-1beta) release and cooperative transactivation by NF-kappaB and ATF-4 : IL-1beta facilitates HDAC-1/2 dissociation from promoter
Tewari et al., Arch Oral Biol 1996 (Periodontitis) : The aim now was to investigate whether recombinant ( r ) IL-1 beta induces the stimulation of NF kappa B and its inhibitor proteins in human gingival fibroblasts and to understand if inhibition of its activity affects collagenase gene expression
Lafuente et al., J Hypertens 2008 : However, the high concentration of D-glucose did increase iNOS expression in response to low concentrations of IL-1beta ( 2.5 and 5 ng/ml ), as well as the IL-1beta induced activation of both ERK 1/2 and NF-kappaB
Ishinaga et al., EMBO J 2007 (Haemophilus Infections) : Acetylation of p65 at lysine 221 by TGF-beta1 is critical for synergistic enhancement of bacteria induced DNA binding activity, NF-kappaB activation, NF-kappaB dependent transcription of TNF-alpha and IL-1beta and interstitial polymorphonuclear neutrophil infiltration in vitro and in vivo
Boonkaewwan et al., J Agric Food Chem 2008 : It was previously demonstrated that stevioside attenuates NF-kappaB dependent TNF-alpha and IL-1beta synthesis in LPS stimulated monocytes
Veillat et al., Fertil Steril 2009 (Endometriosis...) : This study showed a significant dose dependent increase of MIF protein secretion and mRNA expression, the NF-kappaB translocation into the nucleus, I kappaB phosphorylation, I kappaB degradation, and human MIF promoter activity in endometriotic stromal cells in response to IL-1 beta
Jiang et al., J Biol Chem 2004 (Inflammation) : The present study examined the effect of angiotensin II on interleukin-1beta induced NF-kappaB activation and the subsequent expression of inducible NO synthase (iNOS) and vascular cell adhesion molecule-1 ( VCAM-1 ) in cultured rat vascular smooth muscle cells ... The inhibitory effect of angiotensin II on iNOS expression was associated with a down-regulation of the sustained activation of extracellular signal regulated kinase ( ERK ) and NF-kappaB by interleukin-1beta , whereas the effect on VCAM-1 was independent of ERK activation
Wieser et al., J Clin Endocrinol Metab 2005 (Endometriosis) : EMSAs showed that sulindac dramatically decreased NF-kappaB activation and diminished TNFalpha and IL-1beta induced NF-kappaB DNA binding activity
Xie et al., J Biol Chem 2004 : Inhibition of ERK1/2, JNKs, and PKC-alpha/beta1 had no effect on NF-kappaB activation, whereas inhibition of PKC-theta and PKC-zeta inhibited IL-1beta stimulated activation of NF-kappaB
Martínez-Flórez et al., J Nutr 2005 : Although the mode of action remains to be clarified, our findings support the view that the mechanism of action is via inhibition of IL-1beta induced NF-kappaB activation
Wright et al., J Cell Physiol 1999 : IL-1beta and TNF-alpha stimulated nuclear NF-kappaB levels by about fourfold and fivefold, respectively, in HASMCs
Parmentier et al., Eur Respir J 2000 : The effect of the antioxidant compound, N-acetyl-L-cysteine (NAC), on IL-1beta release and regulation of NF-kappaB in a human myelo-monocytic cell line ( THP-1 ) differentiated into macrophages was studied
Yang et al., Cell Signal 2002 (Asthma...) : IL-1beta induced activation of NF-kappaB correlated with the degradation of IkappaB-alpha in TSMCs. IL-1beta induced NF-kappaB activation, COX-2 expression, and PGE ( 2 ) synthesis were inhibited by the dominant negative mutants of NIK and IKK-alpha, but not by IKK-beta ... IL-1beta induced COX-2 expression and PGE ( 2 ) synthesis were completely inhibited by PD98059 ( an inhibitor of MEK1/2 ) and SB203580 ( an inhibitor of p38 inhibitor ), but these two inhibitors had no effect on IL-1beta induced NF-kappaB activation, indicating that activation of p42/44 and p38 MAPK and NF-kappaB signalling pathways were independently required for these responses
Fukuda et al., Invest Ophthalmol Vis Sci 2006 : Neither IL-4 nor -13 affected the IL-1beta induced activation of NF-kappaB or the AP-1 component c-Jun
Shimpo et al., Hypertension 2000 : Increased nitrite production by aspirin-like drugs was accompanied by increased iNOS mRNA and protein accumulation in VSMCs. Addition of IL-1beta activated nuclear factor kappaB (NF-kappaB) in VSMCs, but sodium salicylate did not affect IL-1beta induced NF-kappaB activation
Alvarez-Soria et al., Rheumatology (Oxford) 2008 (Osteoarthritis, Knee) : Diacerein and NSAIDs inhibited IL-1beta stimulated NF-kappaB activation in synoviocytes and chondrocytes except indomethacin in synoviocytes
Terzidou et al., J Clin Endocrinol Metab 2006 : OTR promoter contains putative transcription factor binding sites for activating protein-1 (AP-1), CCAAT/enhancer binding protein (C/EBP), and nuclear factor-kappaB (NF-kappaB) , which may be activated by IL-1beta , whose concentrations increase with labor
Li et al., J Biol Chem 2006 (Breast Neoplasms) : Interleukin-1beta induction of NFkappaB is partially regulated by H2O2 mediated activation of NFkappaB inducing kinase ... IL-1beta induced H2O2 production in MCF-7 cells and clearance of this ROS through the expression of GPx-1 reduced NFkappaB transcriptional activation by inhibiting NIK mediated phosphorylation of IKKalpha ... Although IKKalpha and IKKbeta were both involved in IL-1beta mediated activation of NFkappaB , only the IKKalpha dependent component was modulated by changes in H2O2 levels ... In summary, our studies have demonstrated that redox regulation of NIK by H2O2 is mechanistically important in IL-1beta induction of NFkappaB activation
Bonizzi et al., Mol Cell Biol 1999 (Adenocarcinoma) : Reactive oxygen intermediate dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity ... Stimulation of lymphoid cells with interleukin-1beta (IL-1beta) led to ROI production and NF-kappaB activation, which could both be blocked by antioxidants or FLAP inhibitors, confirming that 5-LOX was the source of ROIs and was required for NF-kappaB activation in these cells ... This pathway involves the Rac1 and Cdc42 GTPases, two enzymes which are not required for NF-kappaB activation by IL-1beta in epithelial cells
Shah et al., Int J Cancer 2006 (Colonic Neoplasms) : Ursodeoxycholic acid inhibits interleukin 1 beta [ corrected ] and deoxycholic acid induced activation of NF-kappaB and AP-1 in human colon cancer cells
Kan et al., Am J Physiol 1999 : TNF-alpha enhanced MAP kinase activity was associated with an increase in IL-1beta stimulated NF-kappaB activity
Yan et al., J Immunol 2006 (Inflammation) : IL-1beta activated NF-kappaB but not ERK or p38
Bureau et al., J Immunol 2000 (Airway Obstruction...) : These results indicate that sustained NF-kappaB activation in asthmatic bronchi is driven by granulocytes and is mediated by IL-1beta and TNF-alpha
Gao et al., Biol Pharm Bull 2009 (Brain Ischemia...) : We also determined expression of TLR4 mRNA and MyD88 mRNA by in situ hybridization ( ISH ), activation of nuclear factor (NF)-kappaB by electrophoretic mobility-shift analysis ( EMSA ), and expression of interrleukin (IL)-1beta protein by Western blot
Tiemessen et al., Proc Natl Acad Sci U S A 2007 : In addition, the monocytes/macrophages have reduced expression of HLA-DR and a strongly reduced capacity to respond to LPS in terms of proinflammatory mediator production ( IL-1beta , IL-6, IL-8, MIP-1alpha, TNF-alpha ), NFkappaB activation , and tyrosine phosphorylation
Welsh , J Biol Chem 1996 : Binding to the NF-kappaB element was strongly induced by IL-1beta , but not by acetylsphingosine or PMA
Cao et al., Biol Reprod 2005 : Curcumin ( 10 ( -8 ) M ), which is known for inhibiting NFkappaB activation, inhibited IL1B induced MIF secretion as well as NFkappaB nuclear translocation and DNA binding
Chen et al., Exp Eye Res 2010 (Dry Eye Syndromes) : NF-kappaB inhibitor suppressed hyperosmoticity induced IL-1beta production
Chang et al., Ann Thorac Surg 2004 (Shock, Septic) : Nuclear factor kappaB (NF-kappaB) plays a central role in the regulation of IL-1beta and subsequent IL-1beta dependent inflammatory processes ... Our results suggest that elevated activation of NF-kappaB , at least in part, contributes to the dysregulated expression of IL-1beta and iNOS in the lungs of senescent animals
Li et al., Arterioscler Thromb Vasc Biol 2007 (Inflammation) : Reporter gene assays showed that FXR ligands activated an FXR reporter gene and suppressed IL-1beta induced nuclear factor (NF)-kappaB activation and iNOS in a manner that required functional FXR and SHP
Yamanaka et al., Clin Cancer Res 2004 (Neoplasm Invasiveness...) : We examined the role of interleukin (IL)-1beta in activation of nuclear factor kappaB (NF-kappaB) and the biological function of activated NF-kappaB in gastric carcinoma cells ... In vivo expression of IL-1beta and MMP-9 and activation of NF-kappaB in 10 surgically resected gastric carcinoma specimens were examined immunohistochemically ... IL-1beta enhanced NF-kappaB activation, MMP-9 expression, and the invasive ability of GCTM-1 ... The present results suggest that IL-1beta increases the invasive ability of carcinoma cells through activation of NF-kappaB and the resulting MMP-9 expression
Bonizzi et al., Eur J Biochem 1996 : In this report, we first demonstrated that IL-1 beta is a potent activator of NF-kappa B in various epithelial transformed cell lines ( OVCAR-3, SKOV-3, MCF7 A/Z ) ... In these cells, IL-1 beta rapidly induces NF-kappa B through a complete degradation of I kappa B-alpha, while H2O2 activates NF-kappa B with slower kinetics through a partial degradation of I kappa B-alpha, p100 and p105 ... We showed that IL-1 beta mediated induction of NF-kappa B in OVCAR-3 and in other epithelial cell lines does not proceed through the production of reactive oxygen intermediates, while the same cytokine activates NF-kappa B in lymphoid cells through the intracellular generation of H2O2
Uehara et al., J Biol Chem 1999 (Glioma) : The activation of NF-kappaB and the subsequent cytokine induced neutrophil chemoattractant induction in response to interleukin-1beta (IL-1beta) were inhibited by proteasome inhibitors, MG132 and proteasome inhibitor I. Translocation of NF-kappaB into nuclei occurs by the phosphorylation, multi-ubiquitination, and degradation of IkappaBalpha, a regulatory protein of NF-kappaB ... These results indicate that the transient translocation of NF-kappaB in response to IL-1beta may be partly dependent on transient proteasome activation
Okuno et al., Scand J Gastroenterol 2002 : The inhibition of NF-kappaB activation markedly blocked both IL-1beta- and TNF-alpha induced IL-8 and MCP-1 mRNA expression, but did not affect MMP-1 mRNA expression
Kelly et al., J Biol Chem 2003 : The data also indicate that activation of the transcription factor, nuclear factor kappa B (NF kappa B), may play a role, since the inhibitory effect of LPS and IL-1 beta on LTP was attenuated by the NF kappa B inhibitor, SN50 ; consistently, LPS and IL-1 beta led to activation of NF kappa B in entorhinal cortex
Choi et al., Scand J Gastroenterol 2008 (Adenocarcinoma...) : Furthermore, LGG attenuated the IL-1beta induced transcriptional activation of the IL-8 gene and the NF-kappaB-responsive gene, and attenuated the IL-1beta induced IkappaBalpha degradation
Chang et al., Nephron. Experimental nephrology 2006 (Inflammation) : NF-kappaB was activated within 30 min by tumor necrosis factor-alpha (TNF-alpha) or interleukin-1beta (IL-1beta) ... Intracellular ROS was not produced until 30 min and also antioxidants such as N-acetylcysteine and tiron had no effect on the TNF-alpha- or IL-1beta induced NF-kappaB activation ... Silymarin dose-dependently inhibited the TNF-alpha- or IL-1beta induced NF-kappaB activation and MCP-1 expression ... Induction of NF-kappaB within 30 min by TNF-alpha- and IL-1beta was mediated through intracellular calcium but not ROS
Bode et al., J Immunol 2001 : The observation that inhibition of IL-6 induced transcriptional activation of this promoter by IL-1beta is reversed by cotransfection with I-kappaBalpha provides evidence that NF-kappaB activation by IL-1beta is responsible for inhibition of IL-6 mediated trans activation of the alpha(2)-macroglobulin gene ... Additional data are provided indicating that the activation of NF-kappaB by IL-1beta is also responsible for the inhibition of other IL-6-inducible genes, such as the alpha(1)-antichymotrypsin gene as well as the suppressor of cytokine signaling 3 gene, suggesting a more general relevance of this mechanism for transcriptional regulation
Kessler et al., J Cardiovasc Pharmacol 1997 : Thiopental did not affect the IL-1beta stimulated activation of NF-kappaB in VSMCs
Shimpo et al., J Orthop Sci 2009 (Osteoarthritis) : IL-1beta strongly increased the translocation of NF-kappaB to the nucleus and the phosphorylation of extracellular-signal regulated kinase, p38, and c-Jun amino-terminal kinase ; but the up-regulation was not inhibited by DEX or COX inhibitors
Moodie et al., FASEB J 2004 : However, H2O2, tumor necrosis factor-alpha (TNF-alpha), and IL-1beta significantly increased NF-kappaB activation and expression of IL-8 compared with control cells
Eng et al., Microvasc Res 2003 : Further supporting NF-kappaB regulation of PDGF-B, activation of NF-kappaB by interleukin (IL)-1beta resulted in increased PDGF-B transcript levels
Zhang et al., Cell Immunol 2003 : Investigation of the mechanism involved in MIP-1beta induction by IL-1beta showed that IL-1beta activated the nuclear factor kappa B (NF-kappaB) promoter in Huh7 cells ... In addition, caffeic acid phenethyl ester ( CAPE ), a specific inhibitor of the activation of NF-kappaB, not only abolished IL-1beta mediated NF-kappaB promoter activation , but also blocked IL-1beta induced MIP-1beta expression
Obara et al., Arterioscler Thromb Vasc Biol 2000 (Arteriosclerosis) : Electromobility gel shift and luciferase assays demonstrated that overexpression of IkappaBDeltaN inhibited NF-kappaB activation induced by TNF-alpha or interleukin-1beta (IL-1beta)
Vakkila et al., J Immunol Methods 2004 : NF-kappaB responses to IL-1beta , CD40L, and LPS were donor dependent ( n=7 ), correlated with the quality of iDC preparations ( p=0.002 ), and IL-12 p70 production ( p=0.010 )
Müerköster et al., Med Klin (Munich) 2004 (Carcinoma, Pancreatic Ductal...) : The autocrine secretion of IL-1beta contributes to a constitutively increased NF-kappaB activity in PDAC cells along with a chemoresistant phenotype
Li et al., Am J Physiol Cell Physiol 2009 : We conclude that IL-1alpha and IL-1beta act via an oxidant- and AKT/Foxo independent mechanism to activate p38 MAPK, stimulate NF-kappaB signaling, increase expression of atrogin1/MAFbx and MuRF1, and reduce myofibrillar protein in differentiated myotubes
Li et al., Chin Med J (Engl) 2003 : mRNA expression of proinflammatory cytokines ( IL-1 beta , IL-6, TNF-alpha, and MCP-1 ) and activation of NF-kappa B of HMC were measured using Reverse transcription-polymerase chain reaction ( RT-PCR ) and electrophoretic mobility shift assay ( EMSA ) respectively
Song et al., Int J Mol Med 2007 : The molecular mechanism by which RAE inhibited iNOS gene expression appeared to involve the inhibition of NF-kappaB activation as a result of RAE 's suppression of IL-1beta and IFN-gamma induced IkappaBalpha degradation
Choi et al., Food Chem Toxicol 2010 (Sarcoma) : Moreover, IL-1beta induced activator protein-1 (AP-1) and nuclear factor-kappaB (NF-kappaB) activation were inhibited by luteolin
Cobb et al., Eur J Immunol 1996 : As expected, the protease inhibitors blocked the activation of nuclear factor (NF)-kappa B in response to IL-1 beta stimulation ... In contrast, norLEU did not prevent IL-1 beta induced nuclear translocation of NF-kappa B
Wehkamp et al., J Invest Dermatol 2006 : Pseudomonas aeruginosa- and IL-1beta mediated induction of human beta-defensin-2 in keratinocytes is controlled by NF-kappaB and AP-1 ... Transcription factor ELISAs indicated that the NF-kappaB heterodimer p50-p65 binds to all three NF-kappaB sites in the hBD-2 promoter upon stimulation of primary keratinocytes with IL-1beta and PA
Sato et al., Nat Immunol 2005 : TAK1-deficient cells failed to activate transcription factor NF-kappaB and mitogen activated protein kinases in response to interleukin 1beta , tumor necrosis factor and Toll-like receptor ligands
Catley et al., FEBS Lett 2003 : IL-1beta dependent activation of NF-kappaB mediates PGE2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase
Jin et al., Ann N Y Acad Sci 2002 (Colonic Neoplasms) : Thalidomide inhibited interleukin (IL) 1beta induced NFkappaB transcriptional activation and IL-8 production in Caco-2 colon cancer cells
De Valck et al., Biochem Biophys Res Commun 1997 : However, A20 mutants that no longer associated with 14-3-3 proteins could still fully inhibit NF-kappaB activation induced by tumor necrosis factor, interleukin-1beta or phorbol 12-myristate 13-acetate, thus excluding a crucial role for 14-3-3 interaction in this A20 function
Boesen et al., American journal of physiology. Renal physiology 2008 : IL-1beta activated NF-kappaB and increased ET-1 release in a concentration dependent manner
Markovic et al., J Mol Med (Berl) 2006 (Arthritis, Rheumatoid) : As to the mechanism of inhibition, electrophoretic mobility shift assay experiments demonstrated that exposure of FLS to hyperthermia prevents IL-1beta induced NF-kappaB translocation and subsequent DNA binding
Wang et al., Am J Physiol Lung Cell Mol Physiol 2005 : As expected, IL-1beta stimulated translocation of NF-kappaB into the nucleus and degradation of IkappaB-alpha were blocked by helenalin but not by U0126, SB-202190, or SP-600125
Kim et al., Exp Mol Med 2008 (Asthma...) : The stimulation of lymphoid cells with TNF-alpha, IL-1beta , and LPS resulted in significant ROS production and NF-kappaB activation
Takahashi et al., Atherosclerosis 2002 : In addition, IL-1beta induced NF-kappaB activation in VSMC, an effect that was increased by the addition of beta-VLDL
Yuan et al., J Biol Chem 2001 : The results showed that Smad3 and Smad4, but not Smad1 or Smad2, mimicked the inhibitory effect of TGF-beta and abrogated interleukin-1beta (IL-1beta) induced stimulation of MMP-1 promoter activity and NFkappaB-specific gene transcription in dermal fibroblasts
Koziczak-Holbro et al., J Biol Chem 2007 (Inflammation) : IRAK-4 KD cells are severely impaired in NFkappaB , JNK, and p38 activation in response to IL-1beta or TLR7 ligand
Basile et al., J Biol Chem 1997 : Role of NF-kappaB in tumor necrosis factor-alpha and interleukin-1beta regulation
Jobin et al., J Immunol 1997 : IL-1beta stimulated NF-kappaB nuclear translocation and NF-kappaB dependent IL-1beta and IL-8 expression in both Caco-2 and HT-29 cells as assayed by electrophoretic mobility shift assay, immunofluorescence, kappaB-luciferase transfection, reverse transcriptase-PCR analysis and ELISA ... These data show that IL-1beta induces NF-kappaB activity and expression of NF-kappaB dependent genes in colonic epithelial cells and suggest altered regulation of IkappaB alpha degradation compared with other cell lineages, which may result in their increased responsiveness to therapeutic blockade
Largo et al., Osteoarthritis Cartilage 2003 (Osteoarthritis, Knee) : Glucosamine inhibits IL-1beta induced NFkappaB activation in human osteoarthritic chondrocytes
Akanji et al., Inflamm Res 2010 : Determine the effect of IL-1beta and dynamic compression on NFkappaB activation and IkappaB-alpha gene expression in chondrocyte/agarose constructs
Tsukihara et al., Am J Reprod Immunol 2004 : IL-1beta induced expression of phosphorylated IkappaB and the activation of NF-kappaB
de-Mello et al., Biochem Pharmacol 1996 (Insulinoma...) : Moreover, ebselen did not prevent IL-1 beta induced NF-kappa B activation
Crofford et al., Arthritis Rheum 1997 (Arthritis, Rheumatoid) : IL-1 beta rapidly stimulated the translocation of the p65, p50, and c-rel NF-kappa B subunits from the cytoplasm to the nucleus
Griffin et al., J Biol Chem 2006 (Astrocytoma...) : Persistent interleukin-1beta signaling causes long term activation of NFkappaB in a promoter-specific manner in human glial cells ... Persistent activation of the transcription factor is seen in numerous chronic inflammatory disease states, and we have previously demonstrated sustained activation of NFkappaB in human glial cells upon stimulation with interleukin (IL)-1beta ... However, in vitro analysis of enzyme activity demonstrates that IL-1beta causes the long term activation of the IkappaB kinase complex leading to chronic phosphorylation of the newly synthesized IkappaBalpha signal response domain and persistent activation of NFkappaB ... Such sustained activation of NFkappaB is dependent on the continuous presence and activity of IL-1beta
Lucio-Cazana et al., J Am Soc Nephrol 2001 : Experiments that used pharmacologic and genetic inhibitors showed that the IL-1beta-inducible MCP-1 expression was dependent on nuclear factor-kappaB (NF-kappaB) and independent of activator protein 1 (AP-1) ... These data suggested that ( 1 ) constitutive and IL-1beta-inducible expression of MCP-1 was differently regulated by AP-1 and NF-kappaB and ( 2 ) t-RA inhibited selectively the constitutive expression of MCP-1 via intervention in the AP-1 pathway
Jiang et al., Arterioscler Thromb Vasc Biol 2001 : IL-1beta induced a rapid and transient activation of nuclear factor-kappaB (NF-kappaB) , followed by a prolonged activation of NF-kappaB that was required to induce iNOS expression ... These data suggest that ERK activity is required for persistent NF-kappaB activation by IL-1beta that is necessary for iNOS gene expression
Kammanadiminti et al., J Biol Chem 2006 (Colitis) : Treatment with SAP inhibited NF-kappaB activation induced by interleukin-1beta ; specifically, the NF-kappaB-DNA binding, nuclear translocation of p65 subunit, and phosphorylation of IkappaB-alpha were reduced
Kiela et al., Am J Physiol Gastrointest Liver Physiol 2005 (Colitis...) : Moreover, individual boswellic acids were demonstrated to increase the basal and IL-1beta stimulated NF-kappaB activity in intestinal epithelial cells in vitro as well as reverse proliferative effects of IL-1beta
Kao , Exp Gerontol 2006 (Arthritis, Rheumatoid) : EMSA data confirm that PDCT, at concentrations sufficient to completely block IL-1beta induced HAS1 transcription, also entirely blocks IL-1beta induced NF-kappaB translocation
Chen et al., Mol Pharmacol 2000 : NF-kappaB DNA-protein binding and ICAM-1 promoter activity were enhanced by IL-1beta and these effects were inhibited by tyrphostin 23, but not by PD 98059 or SB 203580
Doi et al., Atherosclerosis 2002 : Both IL-1beta and TNF-alpha stimulated NF-kappaB activity, iNOS mRNA and protein expression with massive nitrite/nitrate ( NOx ) production in rat VSMCs. PTK inhibitors ( genistein, herbimycin A ) dose-dependently inhibited the cytokine stimulated NOx production and iNOS mRNA expression
Branski et al., Laryngoscope 2010 : IL-1 beta increased nuclear factor (NF)-kappaB activation and nuclear translocation
Jalal et al., J Am Soc Nephrol 2006 : In agreement with the pharmacologic inhibition studies, siRNA directed against c-Src specifically limited c-Src protein expression and inhibited IL-1beta mediated induction of NF-kappaB DNA binding activity, whereas control siRNA had no effect ... Conversely, overexpression of constitutively active c-Src augmented basal and IL-1beta mediated induction of NF-kappaB DNA binding activity and NO production
Bianchi et al., Neurobiol Aging 2010 (Encephalitis...) : We show here that : ( 1 ) S100B also stimulates AP-1 transcriptional activity in microglia via RAGE dependent activation of JNK ; ( 2 ) S100B upregulates IL-1beta and TNF-alpha expression in microglia via RAGE engagement ; and ( 3 ) S100B/RAGE induced upregulation of COX-2, IL-1beta and TNF-alpha expression requires the concurrent activation of NF-kappaB and AP-1
Chen et al., Diabetes 2000 (Insulinoma) : However, normal IL-1beta mediated translocation of NF-kappaB and induction of inducible nitric oxide synthase expression and nitric oxide production was severely impaired in the INS-1res cell lines, suggesting a mechanism for the IL-1beta resistance
Minoda et al., Biochem Biophys Res Commun 2009 : Overexpression of FBXW5 inhibited IL-1beta induced activation of JNK/p38 MAPKs and NF-kappaB as well as phosphorylation of TAK1 on Thr187. Conversely, knockdown of FBXW5 resulted in the prolonged activation of TAK1 upon IL-1beta stimulation
Sugiura et al., Nihon Rinsho Meneki Gakkai Kaishi 2007 (Arthritis...) : Mutations of cyropyrin lead to the persistent production of IL-1beta and activation of NF-kappaB , followed by excessive inflammtory reactions
Park et al., J Biol Chem 2004 : NF-kappaB activation induced by tumor necrosis factor (TNF)-alpha, interleukin-1beta , and lipopolysaccharide was also inhibited by FAF1 overexpression
Chen et al., Biochem Pharmacol 2007 (Lung Neoplasms) : Pretreatment of cells with tangeretin inhibited IL-1beta induced p38 MAPK, JNK, and AKT phosphorylation and the downstream activation of NF-kappaB
Kwon et al., Diabetes 1998 : TLCK and MG 132 inhibited both IL-1beta induced activation of NFkappaB and degradation of IkappaBalpha by islets and RINm5F cells
Amrani et al., J Immunol 1999 : Using EMSA, we show that stimulation with TNF-alpha or IL-1 beta induces NF-kappa B DNA binding activity in human airway smooth muscle cells
Sugiyama et al., J Biol Chem 1999 : IkappaBalphaM was resistant to stimulus dependent degradation and suppressed NF-kappaB activation induced by TNF-alpha ( 10 ng/ml ) or IL-1beta ( 10 ng/ml )
Saldeen et al., Biochem Biophys Res Commun 1994 : Interleukin-1 beta induced activation of NF-kappa B in insulin producing RINm5F cells is prevented by the protease inhibitor N alpha-p-tosyl-L-lysine chloromethylketone ... Using the insulin producing rat cell line RINm5F and an electrophoretic mobility shift assay ( EMSA ), it was presently found that IL-1 beta induced a rapid activation ( 5 min ) of the transcription factor NF-kappa B and that this event was prevented by the protease inhibitor N alpha-p-tosyl-L-lysine chloromethylketone ( TLCK )
Masamune et al., FEBS Lett 1995 : N, N,N-trimethylsphingosine inhibits interleukin-1 beta induced NF-kappa B activation and consequent E-selectin expression in human umbilical vein endothelial cells ... Electrophoretic mobility shift assay revealed that TMS inhibited IL-1 beta induced NF-kappa B activation, which is essential for E-selectin expression
Sulciner et al., Mol Cell Biol 1996 : In addition, expression of a dominant negative rac1 mutant ( N17rac1 ) inhibits basal and interleukin 1beta stimulated NF-kappaB activity
Xu et al., Am J Physiol Cell Physiol 2006 (MAP Kinase Signaling System) : Ribosomal S6 kinase-1 modulates interleukin-1beta induced persistent activation of NF-kappaB through phosphorylation of IkappaBbeta ... In conclusion, in the ERK signaling cascade, RSK1 is a key component that directly phosphorylates IkappaBbeta and contributes to the persistent activation of NF-kappaB by IL-1beta
Wang et al., Cytokine 2009 (Acute Lung Injury) : ZD 7155 also reduced the mRNA expression of TNF-alpha and IL-1 beta , inhibited the activation of NF-kappaB and AP-1, and improved lung histopathology
Kühn et al., J Immunol 2000 : However, when the IL-1 beta dependent induction of NF-kappa B was inhibited, the antiapoptotic effect of IL-1 beta was partially reversed, suggesting that NF-kappa B-mediated gene activation is part of the protective mechanism
Munitz et al., Gastroenterology 2010 (Colitis...) : In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6, interleukin-1beta , and tumor necrosis factor alpha ) and activation of MAPK and NF-kappaB in Pirb-/- macrophages following bacterial activation
Sasu et al., Am J Physiol Heart Circ Physiol 2000 : IL-1beta ( 1 ng/ml ) induced marked and persistent NF-kappaB activation in VSMC that was maximal at 1 h and persisted for 3 days
Isoda et al., Arterioscler Thromb Vasc Biol 2006 (Atherosclerosis...) : Investigation of potential signaling pathways demonstrated that metformin diminished IL-1beta induced activation and nuclear translocation of nuclear factor-kappa B (NF-kappaB) in SMCs
Mumbengegwi et al., Mol Cell Biol 2008 : The compartmentalized production of superoxide ( *O ( 2 ) ( - ) ) by endosomal NADPH oxidase is important in the redox dependent activation of NF-kappaB following interleukin 1beta (IL-1beta) stimulation
Raymond et al., Biochem Pharmacol 2010 : Both LT and DN-p38 decreased IL-1beta induced NF-kappaB luciferase activity
Dossumbekova et al., Arthritis Rheum 2007 : Cyclic tensile strain rapidly inhibited the IL-1beta induced nuclear translocation of NF-kappaB , but not its IL-1beta induced phosphorylation at serine 276 and serine 536, which are necessary for its transactivation and transcriptional efficacy, respectively
Martin et al., Osteoarthritis Cartilage 2005 : IL-1beta enhanced both AP-1 and NF-kappaB binding, whereas H ( 2 ) O ( 2 ) only activated AP-1 ... H ( 2 ) O ( 2 ) pre-treatment decreased the IL-1beta activation of NF-kappaB ... The different regulation of NF-kappaB and AP-1 by H ( 2 ) O ( 2 ) and IL-1beta underlines the distinct roles played by the two transcription factors in the regulation of gene expression
Albrecht et al., Cell Signal 2007 : Activation of NF-kappaB by IL-1beta blocks IL-6 induced sustained STAT3 activation and STAT3 dependent gene expression of the human gamma-fibrinogen gene ... In summary, our results indicate that expression of the gamma-fibrinogen gene is mainly controlled by the strength of late phase STAT3 activation, which in turn is negatively regulated by the extent of IL-1beta mediated NF-kappaB activity
Andoh et al., Pancreas 2000 (Pancreatic Neoplasms) : In PANC-1 cells, IL-1beta and TNF-alpha induced a rapid activation of nuclear factor (NF)-kappaB , and TGF-beta1 enhanced this activation slightly
Kacimi et al., Circulation 1997 (Anoxia...) : Radioligand binding and electrophoretic mobility shift assays showed that during chronic hypoxia, IL-1 receptor density and activity of the transcription factor NF-kappaB induced by IL-1beta were decreased, which may account at least in part for the decrease in iNOS expression
Pousset et al., Eur Cytokine Netw 2000 : Using electrophoretic mobility shift assay ( EMSA ), we show that IL-1beta induced NFkappaB activation in primary culture of mouse astrocytes is mediated by the interaction of this cytokine with the IL-1 type I receptor/IL-1 receptor accessory protein complex, as demonstrated by the ability of blocking monoclonal antibodies against these receptors to attenuate NFkappaB activation ... Furthermore, anti-inflammatory cytokines such as IL-4 and IL-10 that block IL-1b induced NFkappaB activation also attenuate IL-1beta induced Akt phosphorylation, despite the fact that IL-4 and IL-10 in isolation induced Akt phosphorylation
Luo et al., Toxicol Appl Pharmacol 2009 (Second Messenger Systems) : Moreover, IL-1beta stimulated NF-kappaB and CaMKII phosphorylation through MyD88 dependent PI-PLC/PKCalpha/c-Src/ROS and PI-PLC/Ca2+/CaM pathways, respectively
Bannerman et al., J Clin Invest 2002 : The Fas associated death domain protein suppresses activation of NF-kappa B by LPS and IL-1 beta ... FADD ( -/- ) MEFs were also resistant to NF-kappa B activation induced by IL-1 beta ... Together, these data indicate that FADD negatively regulates LPS- and IL-1 beta induced NF-kappa B activation and that this regulation occurs upstream of I kappa B degradation
Hoare et al., Am J Physiol 1999 : In contrast to NAC, the metal chelators pyrrolidine dithiocarbamate and diethyldithiocarbamate attenuated IL-1beta induced NF-kappaB activation but had no effect on intracellular sulfhydryl content
Saha et al., Am J Physiol Gastrointest Liver Physiol 2008 : Because IL-1beta also activates NF-kappaB signaling, we investigated disparate HKalpha regulation by H. pylori and IL-1beta, testing the hypothesis that IL-1beta induced HKalpha promoter activation is mediated by the transcription factor Sp1
Anthonsen et al., J Biol Chem 2001 : Functional coupling between secretory and cytosolic phospholipase A2 modulates tumor necrosis factor-alpha- and interleukin-1beta induced NF-kappa B activation ... Tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta are potent activators of the transcription factor NF-kappaB , induced during inflammatory conditions ... We have previously shown that both secretory and cytosolic phospholipase A ( 2 ) ( PLA(2) ) are involved in TNF-alpha- and IL-1beta induced NF-kappaB activation ... We show that in addition to inhibitors of secretory and cytosolic PLA(2)s, 5-lipoxygenase inhibitors attenuate TNF-alpha- and IL-1beta stimulated NF-kappaB activation
Darville et al., Diabetologia 1998 : In these cells IFN-gamma potentiation is mostly mediated by GAS and ISRE, suggesting a role for the IFN-gamma induced transcription factors Stat1alpha ( which binds GAS ) and IRF-1 ( which binds ISRE ), which may cooperate with NF-kappaB induced by IL-1beta for iNOS activation
Kuo et al., Am J Respir Crit Care Med 2000 (Tuberculosis, Pulmonary) : Inhibition of NF-kappaB by pyrrolidine dithiocarbamate attenuated IL-1beta and TNF-alpha synthesis
Yamazaki et al., In Vitro Cell Dev Biol Anim 2005 (Sarcoma, Synovial) : Both NF-kappaB and AP-1 deoxyribonucleic acid binding activities were detectable in SW982 cells by EMSA, and they were induced by interleukin-1beta treatment
Katsuyama et al., Endocrinology 1998 (Translocation, Genetic) : Neutral SMase, IL-1beta , and TNF alpha activated NF-kappaB , as revealed by electrophoretic mobility shift assay, and its nuclear translocation, as demonstrated by immunocytochemical study
Huber et al., Mol Hum Reprod 2007 (Endometriosis) : Electrophoretic mobility shift assay revealed that treatment of these cultures with the urinary preparation hCG-A suppressed TNF-alpha- or IL-1beta induced NF-kappaB DNA binding activity, whereas another urinary hCG preparation ( hCG-B ) was less effective
Bi et al., Zhonghua Yi Xue Za Zhi 2008 (Diabetes Mellitus, Experimental...) : In the DM rats the IkappaBalpha protein expression in the skeletal muscle was significantly lower ( P < 0.05 ) and the NF-kappaB P65 DNA binding activity increased, and TNF-alpha, IL-1B , and IL-6 expression levels were up-regulated in comparison with the normal control group
Wang et al., Toxicol Lett 2010 (Osteoarthritis, Knee) : In primary chondrocytes, modest concentrations of E2 reduced interleukin (IL)-1beta dependent NF-kappaB activation and MMP-1 expression
Jun et al., Inflamm Bowel Dis 2006 (Body Weight...) : Pretreatment of human epithelial HT-29 cells with gliotoxin significantly blocked the I-kappaB degradation and NF-kappaB p65 nuclear translocation induced by tumor necrosis factor-alpha or IL-1beta ; these were parallel with the inhibition of IL-8 secretion and intercellular adhesion molecule-1 expression in the same cells
Chockalingam et al., Arthritis Rheum 2007 (Osteoarthritis) : This study was undertaken to examine the role of PKCzeta in interleukin-1beta (IL-1beta) induced NF-kappaB signaling in human OA chondrocytes, and ultimately to better understand its function in the regulation of downstream mediators of cartilage matrix degradation ... Our results show that PKCzeta is involved in the regulation of IL-1beta induced NF-kappaB signaling in human OA chondrocytes, which in turn regulates downstream expression of ADAMTS-4 and NOS2 ... Phosphorylation of PKCzeta and NF-kappaB was induced by IL-1beta treatment in a time dependent manner, and was specifically inhibited by inhibitors of atypical PKCs. Inhibition of PKCzeta suppressed IL-1beta induced up-regulation of ADAMTS-4 messenger RNA ( mRNA ) and aggrecanase activity
Brzoska et al., Ann N Y Acad Sci 1999 : Furthermore, we determined the effect of alpha-MSH on the IL-1 beta induced activation of the nuclear factor kappa B (NF kappa B) -- a major transcription factor for chemokine genes ... Electrophoretic mobility-shift-assays showed that alpha-MSH, in a dose range from 10 ( -6 ) to 10 ( -12 ) M, significantly downregulated the IL-1 beta induced activation of NF kappa B 10 minutes after stimulation
Nakamura et al., Exp Eye Res 2003 : The objective of the study was to investigate the effects of baicalin, baicalein, and wogonin ( plant flavonoids ) on interleukin-6 (IL-6) and interleukin-8 (IL-8) protein production, mRNA expression, and nuclear factor-kappaB (NF-kappaB) binding activities induced by interleukin-1beta (IL-1beta) in human retinal pigment epithelial cell line ( ARPE-19 ) cells
Lee et al., Inflammation 2009 (Colitis) : The TNBS treatment caused colon shortening, increased myeloperoxidase activity, induced IL-1beta , TNF-alpha, and IL-6 expression in the colon, activated NF-kappaB , and potentiated the GAG degrading activities of intestinal microflora
Vallee et al., Exp Cell Res 2004 (Adenocarcinoma...) : Finally, it appeared that in polarized HT29-D4 cells, the IL-1beta induced translocation of NF-kappaB was connected to PKCdelta translocation
Hellweg et al., Ann N Y Acad Sci 2006 : NF-kappaB was activated by TNF-alpha, IL-1beta , PMA, and camptothecin in a dose dependent manner, but not by LPS
Gu et al., J Biol Chem 2003 : Overexpression of p47(phox) synergized with IL-1beta in the activation of an artificial kappaB-luciferase reporter and specifically augmented IL-1beta induced RelA transactivation activity ... p47(phox) overexpression also greatly increased IL-1beta stimulated RelA phosphorylation, whereas it had no effect on I-kappaB degradation or on RelA nuclear translocation or kappaB binding
Blázovics et al., Orv Hetil 2004 (Inflammatory Bowel Diseases) : It became known, that oxidized LDL can inhibit LPS induced binding of the NF-kappaB to DNA and the subsequent expression of TNF-alpha and interleukin-1beta in macrophages as well as oxidized LDL modulates activation of NF-kappaB in mononuclear phagocytes by altering the degradation of I-kappaBs
Cooke et al., Biochem J 2001 : Functional analysis of the interleukin-1-receptor associated kinase ( IRAK-1 ) in interleukin-1 beta stimulated nuclear factor kappa B (NF-kappa B) pathway activation : IRAK-1 associates with the NF-kappa B essential modulator (NEMO) upon receptor stimulation
Pizzi et al., J Biol Chem 2002 : In both cultured rat cerebellar granule cells and mouse hippocampal slices, we examined NF-kappaB/Rel activation induced by two opposing modulators of cell viability : 1 ) interleukin-1beta (IL-1beta) , which promotes neuron survival and 2 ) glutamate, which can elicit toxicity
Liu et al., J Neurosci 2000 : However, pretreatment with oATP downregulated activation of NF-kappaB and AP-1 by IL-1beta or TNFalpha
Wijagkanalan et al., Mol Pharmacol 2008 (Pneumonia) : DPML significantly inhibited tumor necrosis factor alpha, interleukin-1beta , and cytokine induced neutrophil chemoattractant-1 levels, suppressed neutrophil infiltration and myeloperoxidase activity, and inhibited NFkappaB and p38 mitogen activated protein kinase activation in the lung
Zhang et al., Journal of translational medicine 2009 (Diabetes Mellitus, Experimental...) : Inhibition of nuclear factor kappa B (NF-kappaB) activation induced by IL-1beta and IFN-gamma was investigated
Saldeen et al., Autoimmunity 2000 : The acid sphingomyelinase inhibitor SR33557 counteracts TNF-alpha mediated potentiation of IL-1beta induced NF-kappaB activation in the insulin producing cell line Rinm5F ... TNF-alpha activated NF-kappaB in gel shift experiments without inducing iNOS -- as assessed by nitrite formation -- whereas IL-1beta stimulated both NF-kappaB activation and iNOS induction
Luo et al., Toxicol Appl Pharmacol 2008 : Consistently, IL-1beta stimulated both IkappaB-alpha degradation and NF-kappaB translocation into nucleus in these cells
Shimada et al., J Immunol 2002 : EMSAs demonstrated that IL-17, IL-1beta , and TNF-alpha induced NF-kappaB activation within 1.5 h after stimulation, and a blockade of NF-kappaB activation by the pyrrolidine derivative of dithiocarbamate and tosyl-phe-chloromethylketone markedly reduced the IL-17-, IL-1beta-, or TNF-alpha induced IL-6 gene expression
Rovin et al., Cytokine 1999 : Because NF-kappaB is necessary for MCP-1 gene expression, the effect of p38 kinase inhibition on IL-1beta induction of NF-kappaB was measured ... SB 203580 ( up to 25 microM ) had no effect on IL-1beta induced NF-kappaB nuclear translocation or DNA binding activity ... PD 098059, a selective inhibitor of the ERK activating kinase MEK1, had no effect on IL-1beta induced MCP-1 mRNA or protein levels, or on IL-1beta activation of NF-kappaB
Li et al., Am J Physiol Cell Physiol 2006 : We previously showed that the CGRP inhibitory effect was mediated by elevated intracellular cAMP and show here that analogs of cAMP, 8-bromoadenosine 3',5'-cyclic monophosphothioate and the Sp isomer of adenosine 3',5'-cyclic monophosphothioate, mimicked the CGRP suppressive effect on IL-1beta induced ROS formation, NF-kappaB activation , and MCP-1 secretion
Csaki et al., Arthritis Res Ther 2009 (Inflammation) : IL-1beta induced NF-kappaB activation was suppressed directly by cocktails of curcumin and resveratrol through inhibition of Ikappakappa and proteasome activation, inhibition of IkappaBalpha phosphorylation and degradation, and inhibition of nuclear translocation of NF-kappaB
Badgwell et al., Surgery 2002 (Escherichia coli Infections...) : The 2 groups of mice were analyzed for serum levels of interferon-gamma, tumor necrosis factor-alpha, and interleukin-1beta as well as activation of NFkappaB and STAT1, 2 proinflammatory transcription factors
Nagamatsu et al., J Pharmacol Sci 2006 : However, both IL-1beta and IL-6 mRNA induction was suppressed by nuclear factor kappaB (NF-kappaB) inhibitors
Onodera et al., Arthritis Rheum 2004 (Arthritis, Rheumatoid...) : The mRNA up-regulation of IL-8 and IL-1beta by MIF was inhibited by 2 tyrosine kinase inhibitors, a protein kinase C ( PKC ) inhibitor, an activator protein 1 (AP-1) inhibitor, and by an NF-kappaB inhibitor
van der Helm et al., Biochim Biophys Acta 2000 : The results show that the IL-1beta induced expression of group V sPLA ( 2 ) mRNA was time dependent and, similar to that of group IIA sPLA ( 2 ) mRNA, involves activation of NF-kappaB
Sahni et al., Blood 2004 : Compared with free form, fibrinogen bound IL-1beta stimulated increased activation of endothelial cell nuclear factor kappaB (NF-kappaB) , monocyte chemoattractant protein-1 ( MCP-1 ) secretion, and nitric oxide ( NO ) synthesis
Place et al., Biochem Pharmacol 2005 : The selective impact of HDAC inhibitors on TNF-alpha induced NF-(kappa)B activation appears to relate to the fact that the TNF-alpha induced activation of NF-(kappa)B is mediated by the proteasome, whereas NF-kappaB activation by IL-1beta is largely proteasome independent
Xia et al., Glia 2010 : IL-1beta stimulated IkappaBalpha degradation, NF-kappaB nuclear translocation, and transactivation in astrocytes
An et al., Int Immunopharmacol 2002 : Catalposide, the major iridoid glycoside isolated from the stem bark of Catalpa ovata G. Don ( Bignoniaceae ), was found to inhibit the productions of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) , and interleukin-6 (IL-6), and the activation of nuclear factor kappaB (NF-kappaB) in RAW 264.7 macrophages activated with lipopolysaccharide (LPS)
Brouillard et al., J Biol Chem 2001 : Gel shift analysis showed that IL-1beta activated NF-kappaB in Calu-3 cells, and transfection experiments using p50 and RelA expressing vectors showed that exogenous transfected NF-kappaB subunits increased the concentration of CFTR mRNA ... Gel shift analysis with antibody supershifting also showed that IL-1beta caused the binding of NF-kappaB to a kappaB-like response element at position -1103 to -1093 in the CFTR 5'-flanking region
Zetterström et al., Eur Cytokine Netw 1998 (Fever) : Interleukin-1 mediated febrile responses in mice and interleukin-1 beta activation of NFkappaB in mouse primary astrocytes, involves the interleukin-1 receptor accessory protein ... With the aim of investigating the importance of the IL-1RAcP in IL-1 signalling, IL-1alpha and IL-1beta induced febrile responses and IL-1beta mediated activation of NFkappaB in primary astrocyte cultures were examined using IL-1RAcP-deficient ( IL-1RAcP KO ) and wild type mice, respectively ... Furthermore, it was shown that rhIL-1beta activated, in a concentration dependent manner, nuclear translocation of the transcriptional nuclear factor kappa B (NFkappaB) in primary astrocyte cultures prepared from wild type mice, whereas no IL-1beta induced translocation of NFkappaB could be detected in cultures prepared from IL-1RAcP-deficient mice, as revealed by electrophoretic mobility shift assay ( EMSA )
Parhar et al., Mol Cell Biochem 2007 : Investigation of interleukin 1beta mediated regulation of NF-kappaB activation in colonic cells reveals divergence between PKB and PDK transduced events ... We have investigated the role of PKB and PDK1 in IL-1beta induced NF-kappaB activation ... N-tosyl phenylalanyl chloromethyl ketone ( TPCK ), wortmannin and Ly294002 inhibited IL-1beta induced NF-kappaB activation in both systems indicating involvement of the PI3K axis in this response
Martin et al., Inflammation 2003 (MAP Kinase Signaling System...) : Rhein inhibits interleukin-1 beta induced activation of MEK/ERK pathway and DNA binding of NF-kappa B and AP-1 in chondrocytes cultured in hypoxia : a potential mechanism for its disease modifying effect in osteoarthritis
Kidd et al., Neurogastroenterol Motil 2009 (Crohn Disease) : We examined whether interleukin (IL)1beta and Escherichia coli lipopolysaccharide (LPS) induced EC cell 5HT release through Toll-like/IL-1 (TIL) receptor activation, nuclear factor kappa B (NFkappaB) and mitogen activated protein kinase ( MAPK ) phosphorylation and evaluated whether somatostatin could inhibit this phenomenon ... IL1beta caused significant ( P < 0.05 ) NFkappaB and MAPK phosphorylation ( 40-55 % )
Kanda et al., Eur J Immunol 2008 : All the three IL enhanced the basal and IL-1beta induced transcriptional activities of NF-kappaB , while IL-12 and IL-27 enhanced STAT3 and STAT1 activities, respectively
Ahmed et al., J Nutr 2005 : PFE also inhibited the IL-1beta induced phosphorylation of IkappaBalpha and the DNA binding activity of the transcription factor NF-kappaB in OA chondrocytes
Lin et al., J Biomed Sci 2004 : Furthermore, IL-1beta induced activation of nuclear factor-kappaB (NF-kappaB) was inversely correlated with the degradation of IkappaB-alpha in HTSMCs. IL-1beta induced COX-2 expression and PGE ( 2 ) synthesis were inhibited by the NF-kappaB inhibitor pyrrolidinedithiocarbamate
Takada et al., J Biol Chem 2006 (Neoplasm Invasiveness) : Because several of these genes are regulated by NF-kappaB, we postulated that SAHA mediates its effects by modulating NF-kappaB and found that SAHA suppressed NF-kappaB activation induced by TNF, IL-1beta , okadaic acid, doxorubicin, lipopolysaccharide, H ( 2 ) O ( 2 ), phorbol myristate acetate, and cigarette smoke ; the suppression was not cell type-specific because both inducible and constitutive NF-kappaB activation was inhibited
Ikeda et al., Cardiovasc Res 2002 (Cardiomyopathy, Dilated...) : Addition of IL-1beta activated NF-kappaB in cardiac myocytes, while CRP did not affect IL-1beta induced NF-kappaB activation
Shakibaei et al., Biochem Pharmacol 2007 (Osteoarthritis) : Treatment of chondrocytes with curcumin suppressed IL-1beta induced NF-kappaB activation via inhibition of IkappaBalpha phosphorylation, IkappaBalpha degradation, p65 phosphorylation and p65 nuclear translocation
Xiong et al., J Biol Chem 2004 : Similarly, NO attenuates IL-1beta induced NF-kappaB activation
Wu et al., J Neurochem 2004 (Translocation, Genetic) : Consistently, IL-1beta stimulated translocation of NF-kappaB into the nucleus and degradation of inhibitory kappa B-alpha ( IkappaB-alpha ) was revealed by western blotting and immunofluorescence staining, which was blocked by helenalin, but not by U0126, SB202190, or SP600125
Kim et al., J Ethnopharmacol 2007 (Atherosclerosis) : In lipopolysaccharide (LPS) stimulated RAW264.7 cells, HMCO5 inhibited NF-kappaB activation as well as iNOS promoter activity, inhibited the secretion of TNF-alpha and IL-1beta , and directly inhibited the intracellular accumulation of reactive oxygen species
Cepinskas et al., J Cell Biol 2003 (Inflammation...) : We show that the interleukin 1beta induced accumulation of nuclear NFkappaB in human umbilical vein endothelial cell monolayers is dramatically reduced when polymorphonuclear leukocytes ( PMN ) are allowed to migrate across these monolayers ... Furthermore, cross linking of platelet-endothelial cell adhesion molecule-1 ( PECAM-1 ), but not intercellular adhesion molecule-1, reduces human umbilical vein endothelial cell nuclear NFkappaB induced by interleukin 1beta
Quiles-Perez et al., Hepatology 2010 (Carcinoma, Hepatocellular...) : Furthermore, the results obtained in mice treated with DEN to induce hepatocarcinogenesis showed, after treatment with a PARP inhibitor ( DPQ ), a significant reduction both in preneoplastic foci and in the expression of preneoplastic markers and proinflammatory genes ( Gstm3, Vegf, Spp1 [ Opn ], IL6, IL1b , and Tnf ), bromodeoxyuridine incorporation, and NF-kappaB activation in the initial steps of carcinogenesis ( P < 0.05 )
Dauletbaev et al., Respiration 2010 (Cystic Fibrosis) : Both TNF-alpha and IL-1beta activated NF-kappaB and stimulated IL-8 production
Lieb et al., J Neurochem 1996 (Astrocytoma) : Here, we describe that both IL-1 beta and TNF alpha activate the transcription factor nuclear factor-kappa B (NF-kappa B) via production of reactive oxygen intermediates resulting in ACT expression
Bours et al., Toxicology 2000 (Inflammation...) : We demonstrated that NF-kappaB activation by IL-1beta follows three distinct cell-specific pathways
Tetsuka et al., Biochem Biophys Res Commun 1996 : Tyrosine kinase inhibitors, genistein and herbimycin A, do not block interleukin-1 beta induced activation of NF-kappa B in rat mesangial cells ... Since both COX-2 and iNOS promoters have a kappa B binding motif, we have evaluated the effects of tyrosine kinase inhibitors on IL-1 beta induced nuclear factor-kappa B (NF-kappa B) activation by electromobility shift assays ... IL-1 beta rapidly induced the translocation of NF-kappa B in rat mesangial cells ... These data suggest that an upstream tyrosine kinase pathway may not be required for IL-1 beta induced NF-kappa B activation and that the tyrosine kinase pathway may converge with the NF-kappa B pathway down-stream of NF-kappa B activation in rat mesangial cells
Vakkila et al., Drug Discov Today 2005 : NF-kappaB responses to IL-1beta , CD40L, and LPS were donor dependent ( n = 7 ), correlated with the quality of iDC preparations ( p = 0.002 ), and IL-12 p70 production ( p = 0.010 )
Lentsch et al., Am J Pathol 1998 (Alveolitis, Extrinsic Allergic...) : NF-kappaB activation during IgG immune complex induced lung injury : requirements for TNF-alpha and IL-1beta but not complement ... In the current studies we sought to determine whether TNF-alpha, IL-1beta , the complement system and oxidants contribute to the activation of NF-kappaB in the lung
Bian et al., Exp Eye Res 2001 (MAP Kinase Signaling System) : Furthermore, co-administration of U0126 and SB202190 did not affect the induced degradation of IkappaB-alpha and NF-kappaB nuclear translocation, indicating that NF-kappaB is activated by IL-1beta and TNF-alpha independently of activation of MEK/MAPK and p38 pathways in hRPE cells
Kunze et al., Prostaglandins Other Lipid Mediat 2010 (Inflammation) : C4S inhibited the enhanced expression of COX-2 and mPGES1 but had no effect on the IL1beta induced decrease of I-kappaBalpha and nuclear translocation of NF-kappaB
Samuelsson et al., Int J Mol Med 2005 : beta-Amyloid and interleukin-1beta induce persistent NF-kappaB activation in rat primary glial cells ... We observed that the induction of NF-kappaB binding activity induced by either IL-1beta or Abeta ( 25-35 ) showed a peak at 30 min, and significantly declined after 2 h ... The potentiating effect of Abeta ( 25-35 ) on IL-1beta induced NF-kappaB binding activity was observed after 30 min, 2 h and 24 h, and did not significantly differ over time
Goto et al., Cytokine 1999 : Involvement of NF-kappaB p50/p65 heterodimer in activation of the human pro-interleukin-1beta gene at two subregions of the upstream enhancer element
Liu et al., J Biol Chem 2009 : NF-kappaB p65, induced by IL-1beta , interacts with a novel element in the PDGF-D promoter and inhibits PDGF-D transcription
Yasui et al., Thromb Res 2001 : IL-1beta stimulation caused activation of nuclear factor-kappaB (NF-kappaB) and expression of cyclooxygenase-2 (COX-2) mRNA and protein, which were inhibited by daunorubicin
Hu et al., J Huazhong Univ Sci Technolog Med Sci 2005 : It was concluded that the expressions of NF-kappaB in hRPE cells could be increased significantly by IL-1beta and depressed effectively by PDTC ... Also, PDTC could significantly inhibit the activation of NF-kappaB induced by IL-1beta
Castro-Caldas et al., Mediators Inflamm 2003 (Leukemia-Lymphoma, Adult T-Cell) : Finally, when the cells were exposed to Dex ( 1 microM ) prior to stimulation with IL-1beta ( 20 ng/ml ), Dex was efficient in preventing IL-1beta induced NF-kappaB activation
Oakley et al., J Biol Chem 2009 : Lipid rafts and caveolin-1 coordinate interleukin-1beta (IL-1beta) dependent activation of NFkappaB by controlling endocytosis of Nox2 and IL-1beta receptor 1 from the plasma membrane
Zhang et al., Blood 2000 : Exposing primary rat hepatocytes to IL-1beta had no effect on IL-6 mediated STAT3 activation ; instead, IL-1beta activated NF-kappaB associated with 2 IL-6 responsive elements ( STAT3 binding site ) on the rat gamma fibrinogen promoter and blocked STAT3 binding to these regions
Wang et al., Respirology 2001 (Tuberculosis, Pulmonary) : An inhibition of NF-kappaB by pyrrolidine dithiocarbamate attenuated IL-1beta and TNF-alpha synthesis
Liu et al., Zhonghua Yan Ke Za Zhi 2002 : To evaluate the inductive role of interleukin (IL)-1 beta and the inhibitory role of pyrrolidine dithiocarbamate ( PDTC ) on the activation of nuclear factor (NF)-kappaB in the rat retina ... NF-kappa B in the retina can be activated by intraocular IL-1 beta
Guo et al., Glia 2004 (Calcium Signaling...) : Caffeic acid phenethyl ester ( CAPE ), a specific inhibitor of NF-kappaB activation, not only abrogated IL-1beta induced NF-kappaB promoter activation , but also blocked IL-1beta mediated induction of NK-1R gene expression
Liu et al., Proc Natl Acad Sci U S A 2009 : Neither JNK1 activation by IL-1beta or UV nor TNF-alpha induced activation of p38, ERK, or IkappaB kinase complex is affected by the loss of Miz1
Iha et al., EMBO J 2008 (Heart Diseases...) : Here, we show that Tax1 binding protein 1 (TAX1BP1) is a negative regulator of TNF-alpha- and IL-1beta induced NF-kappaB activation and that binding to mono- and polyubiquitin by a ubiquitin binding Zn finger domain in TAX1BP1 is needed for TRAF6 association and NF-kappaB inhibition
Hecker et al., FEBS Lett 1996 : They also suggest that reactive oxygen intermediates do not play a role in the activation of NF-kappa B by IL-1 beta in VSMC, and that transcription factors other than NF-kappa B mediate the induction of iNOS expression by elevating the intracellular concentration of cyclic AMP
Hershko et al., Clin Sci (Lond) 2002 : IL-1beta increased NF-kappaB DNA binding activity, IL-6 mRNA levels and IL-6 production
Brechter et al., Bone 2008 : EMSA showed that IL-1beta and TNF-alpha activated NF-kappaB and AP-1 in MG-63 cells ... IL-1beta stimulated NF-kappaB via a non-canonical pathway ( p52/p65 ) and TNF-alpha via the canonical pathway ( p50/p65 )
Schanstra et al., Immunopharmacology 1999 : It has been shown that B1-receptor induction during inflammation involves interleukin-1beta (IL-1beta) production and activation of nuclear factor-kappaB (NF-kappaB)
Deisher et al., FEBS Lett 1993 : Interleukin-1 beta , TNF-alpha, and LPS induce nuclear factor (NF)-kappa B-like binding activity, which precedes VCAM-1 transcription
Takaya et al., Pancreas 2000 (Pancreatic Neoplasms) : IL-1beta and TNF-alpha induced a rapid activation of nuclear factor (NF)-kappaB in PANC-1 cells, and the increase in chemokine mRNA expression correlated with NF-kappaB activation
Lee et al., Am J Respir Cell Mol Biol 2004 : Dexamethasone, a glucocorticoid, inhibited IL-1beta induced nuclear translocation of NF-kappaB and also the secretion of IL-13 from mast cells
Lacey et al., Arthritis Rheum 2003 (Hyperplasia) : Activation of NF-kappa B was induced by IL-1 beta , but not by MIF ... Anti-MIF mAb had no effect on IL-1 beta induced NF-kappa B nuclear translocation
Legendre et al., Clin Exp Rheumatol 2007 : The drug reduced IL-1Beta induced NF-kappaB and AP-1 DNA binding, as well as the phosphorylation of ERK and JNK
Lührs et al., Dig Dis Sci 2001 (Translocation, Genetic) : Extracellular stimuli, notably interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha) activate NF-kappaB nuclear translocation via IkappaB phosphorylation and degradation ... In cells pretreated with butyrate, a time- and dose dependent inhibition of IL-1beta mediated NF-kappaB nuclear translocation was observed ... These data indicate that inhibition of IL-1beta induced NF-kappaB activation by butyrate does not require an intact IkappaB alpha protein
Katsuyama et al., Endocrinology 1999 : Both IL-1beta and TNF-alpha activated nuclear factor (NF)-kappaB as demonstrated by electrophoretic mobility shift assay
Hattori et al., Hypertension 2006 : A pharmacological activator of AMPK, 5-amino-4-imidazole carboxamide riboside ( AICAR ), dose-dependently inhibited TNF-alpha- and interleukin-1beta induced NF-kappaB reporter gene expression
Tozawa et al., Cancer Lett 2003 (Neoplasms) : Here we demonstrate that IL-1beta induces nuclear translocation of NF-kappaB in human umbilical vein endothelial cells ( HUVEC ) followed by induction of cell surface expression of E-selectin, ICAM-1 and VCAM-1, and subsequently augments adhesion of cancer cells expressing sialyl Lewis antigen, a ligand of E-selectin
Illek et al., Am J Physiol Lung Cell Mol Physiol 2008 : Neither flagellin nor IL-1beta altered transepithelial fluxes of membrane-impermeant dextran ( 10 kDa ) or lucifer yellow ( mol wt = 457 ), but both activated p38, NF-kappaB , and IL-8 secretion ... It is concluded that : 1 ) flagellin and IL-1beta activated p38, NF-kappaB , IL-8, and CFTR dependent anion secretion without altering tight junction permeability ; 2 ) p38 played a role in regulating I ( Cl ) and IL-8 but not NF-kappaB ; and 3 ) p38 was more important in flagellin- than IL-1beta stimulated responses
Kang et al., Cancer Lett 2004 : These results suggest that AAF inhibits IL-1beta gene expression by blocking NF-kappaB/Rel activation
Lindström et al., Mol Pharmacol 2008 : Short-term exposure to HDACi enhanced interleukin (IL)-1beta induced NF-kappaB activity as a result of potentiating IkappaB kinase (IKK)beta activity, thereby leading to persistent turnover of IkappaBalpha/epsilon proteins and prolonging NF-kappaB phosphorylation, nuclear localization, and DNA binding
Waters et al., Arthritis Rheum 2006 (Scleroderma, Diffuse) : IL-1beta signaling required NF-kappaB and MEK activation, along with activation of PKCdelta
Nadjar et al., Biol Psychiatry 2005 (Body Weight) : To assess whether this action is mediated by NFkappaB activation, rats were injected into the lateral ventricle of the brain with a specific inhibitor of NFkappaB activation, the NEMO Binding Domain (NBD) peptide that has been shown previously to abolish completely IL-1beta induced NFkappaB activation and Cox-2 synthesis in the brain microvasculature ... These findings strongly support the hypothesis that IL-1beta induced NFkappaB activation at the blood-brain interface is a crucial step in the transmission of immune signals from the periphery to the brain that underlies further events responsible of sickness behavior
Parikh et al., Shock 2000 (Adenocarcinoma...) : IL-1beta induction of NF-kappaB activation in human intestinal epithelial cells is independent of oxyradical signaling ... Similarly, scavenging of free radicals and oxidants by pyrrolidine dithiocarbamate and dimethyl sulfoxide did not block IL-1beta induced IkappaBalpha degradation and NF-kappaB activation ... Genistein, a nonspecific tyrosine kinase inhibitor, also had no effect on IL-1beta mediated effects on NF-kappaB