Gene interactions and pathways from curated databases and text-mining

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Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Thompson et al., Am J Respir Cell Mol Biol 2006 (Asthma) : CysLT1 receptor engagement induces activator protein-1- and NF-kappaB dependent IL-8 expression
Wang et al., Biochim Biophys Acta 2004 (Sarcoma, Kaposi) : Furthermore, using DNA protein binding experiments, we have shown that IL-8 increased AP-1 and NF Kappa B activity in these cells
Frick et al., Inflamm Bowel Dis 2007 (Inflammation...) : Exposure of human epithelial cells to L. fermentum does not induce NF-kappaB activation and subsequent IL-8 secretion in HeLa cells, whereas Y. enterocolitica induces NF-kappaB activation and high levels of IL-8
Takeda et al., Science 1999 (Limb Deformities, Congenital...) : In contrast, there was no impairment of NF-kappaB activation induced by either interleukin-1 or tumor necrosis factor-alpha in IKKalpha-deficient embryonic fibroblasts and thymocytes, indicating that IKKalpha is not essential for cytokine induced activation of NF-kappaB
Vij et al., J Biol Chem 2006 (Cystic Fibrosis) : Inhibition of the proteasome with bortezomib ( PS-341/Velcade ) also rescued CFTR, but with less efficiency, and suppressed NFkappaB mediated IL8 activation ... The inhibition of the major stress-inducible transcription factor CHOP ( CCAAT/enhancer binding protein homologous protein ) /GADD153 together with bortezomib was most effective in repressing NFkappaB mediated IL8 activation compared with interference of VCP, MLN-273 ( proteasome inhibitor ), or 4-phenylbutyrate ( histone deacetylase inhibitor )
Grassl et al., Cell Microbiol 2003 (MAP Kinase Signaling System) : While NF-kappaB and JNK contribute to IL-8 transcription, p38 MAPK also acts through stabilization of IL-8 mRNA, as confirmed by quantitative RT-PCR and electrophoretic mobility shift assays
Lee et al., J Toxicol Environ Health 2005 : Motorcycle exhaust particles induce IL-8 production through NF-kappaB activation in human airway epithelial cells
Théâtre et al., Am J Respir Cell Mol Biol 2009 (Calcium Signaling) : Although these agonists did not induce significant IL-8 gene expression by these cells, they markedly enhanced TNF-alpha induced NF-kappaB activation, resulting in increased IL-8 expression and release
Chung et al., J Biochem Mol Biol 2007 : NF-kappaB activation by STP-C through the ubiquitinated TRAF6 causes the increased production of IL-8 , an inflammatory chemokine and the enhanced expression of costimulatory molecule ICAM, which might ultimately contribute cellular transformation by the exposure of HVS infected cells with inflammatory microenvironment and chronic activation
Bian et al., Exp Eye Res 2003 (Translocation, Genetic) : This study investigates chemokine secretion induced by co-culture of hRPE cells and monocytes and illustrates the roles of p38 kinase, ERK, JNK/SAPK and NF-kappaB inducing kinase signaling pathways for hRPE IL-8 and MCP-1 secretion induced in hRPE by co-culture with monocytes ... These results suggest that activation of DEX-sensitive, CSA-resistant MEK/ERK and p38 pathways, and activation of NF-kappaB , PKC, and PTK are essential for IL-8 and MCP-1 expression by hRPE cells
Balasubramanian et al., J Gen Virol 2005 : Using specific NF-kappaB inhibitors, it was also shown that HCV-LP induced NF-kappaB activity mediated IL8 production in HUVECs
Dey et al., Cell Death Differ 2008 : We show in this study that R-Roscovitine can downregulate nuclear factor-kappa B (NF-kappaB) activation in response to tumor necrosis factor (TNF)alpha and interleukin 1
Chen et al., J Dermatol Sci 2002 : Propionibacterium acnes induced IL-8 production may be mediated by NF-kappaB activation in human monocytes
Perez et al., Am J Physiol Lung Cell Mol Physiol 2007 (Cystic Fibrosis...) : Continuous inhibition of CFTR-Cl ( - ) conductance for 3-5 days resulted in significant increase in IL-8 secretion at basal ( P = 0.006 ) and in response to 10 ( 9 ) Pseudomonas ( P = 0.0001 ), a fourfold decrease in Smad3 expression ( P = 0.02 ), a threefold increase in RhoA expression, and increased NF-kappaB nuclear translocation upon TNF-alpha/IL-1beta stimulation ( P < 0.000001 )
Hohmann et al., J Biol Chem 1992 (Leukemia, Promyelocytic, Acute) : NF-kappa B activation by phorbol 12-myristate 13-acetate ( PMA ) and interleukin-1 was inhibited by staurosporin
Matsuyama et al., J Immunol 2004 : In this study, we report that the interaction of DDR1b with collagen up-regulates the production of IL-8 , macrophage inflammatory protein-1alpha, and monocyte chemoattractant protein-1 in human macrophages in a p38 MAPK- and NF-kappaB dependent manner
Zhou et al., J Clin Immunol 2004 : IL-8 induction by hyperforin required the activation of AP-1 but not the NF-kappaB transcription factor, thereby distinguishing it from the NF-kappaB dependent IL-8 induction mediated by tumor necrosis factor alpha (TNFalpha)
Kettritz et al., J Biol Chem 2004 : GM-CSF and IL-8 did not activate NF-kappaB in suspended neutrophils but rapidly activated NF-kappaB under adherent conditions on matrix, as shown by IkappaB kinase activity assay, IkappaBalpha degradation, electromobility shift assay, and quantitative reverse transcriptase-PCR ... Specific beta ( 2 ) integrin blockade prevented NF-kappaB activation by GM-CSF and IL-8 on fibronectin ... Co-stimulating CD18 and CD11b with activating antibodies resulted in NF-kappaB activation by GM-CSF and IL-8 in suspended cells
Alzoghaibi et al., Am J Physiol Gastrointest Liver Physiol 2004 (Crohn Disease) : We speculate that AA metabolites increased IL-8 production by enhancing NF-kappaB dependent transcription of IL-8
Adam et al., J Biol Chem 2006 (Calcium Signaling...) : Second, Der p 1-mediated IL-8 expression was mainly dependent on NF-kappaB , whereas Der p 3 and PAR(2)AP regulated IL-8 expression through the activation of both NF-kappaB and AP-1
Pace et al., Immunology 2008 : The combined exposure of 16-HBE to CSE and LPS was associated with ERK activation rather than NF-kappaB activation and with a further increase of IL-8 release and of chemotactic activity toward neutrophils
Kormann et al., Allergy 2009 (Genetic Predisposition to Disease...) : Functional effects of TLR2 variants were analyzed by NF-kappaB dependent luciferase reporter assay and interleukin-8 enzyme linked immunosorbent assay in vitro
Greene et al., Biochim Biophys Acta 1999 : Interleukin-1 receptor associated kinase, IRAK, has been shown to activate NFkappaB in response to interleukin-1
Feng et al., Wei Sheng Wu Xue Bao 2005 : These findings suggest that Pseudomonas pyocyanin can increase IL-8 expression by human airway epithelial cells through MAPKs signaling pathways and the activation of NF-kappaB is also involved in this process
Hwang et al., Oncogene 2004 (Stomach Neoplasms) : The above results suggest that MAPK-AP-1 and ROS-NF-kappaB signaling pathways are involved in the IL-1beta induced IL-8 expression and that these paracrine signaling pathways induce endothelial cell proliferation
Kennedy et al., Am J Respir Cell Mol Biol 1998 (Asthma...) : Mucin significantly reduced IL-8 secretion, and ceruloplasmin significantly increased IL-8 secretion and activation of NF-kappaB
Ondrey et al., Mol Carcinog 1999 (Carcinoma, Squamous Cell...) : We concluded that the early transcription factors NF-kappaB, AP-1, and NF-IL6 are constitutively activated in human HNSCC cell lines and that NF-kappaB and AP-1 promote expression of the pro-inflammatory and pro-angiogenic cytokine IL-8 in HNSCC
Trevino et al., Angiogenesis 2006 (Adenocarcinoma...) : Pharmacologic inhibition of NF-kappaB activity significantly reduced basal IL-8 expression and tumor necrosis factor induced IL-8 expression ( P < 0.05 for both ), yet NF-kappaB activity was not dependent on Src ... We therefore suggest that Src activation, through phosphorylation of STAT3, and NF-kappaB are all required for expression of IL-8 a critical angiogenic promoting factor in pancreatic adenocarcinomas
Mazor et al., Cytokine 2000 : Because activation of NF-kappaB is involved in the regulation of the chemokine interleukin 8 (IL-8) , we hypothesized that the sesquiterpene lactones, isohelenin and parthenolide, would inhibit IL-8 gene expression in cultured human respiratory epithelium
Egan et al., J Biol Chem 1999 : Inhibition of interleukin-1 stimulated NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity ... Inhibition of interleukin-1 stimulated NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity
Németh et al., Immunol Lett 2003 : In the present paper we investigated the effect of pharmacological inhibition of NF-kappaB with pyrrolidinedithiocarbamate ( PDTC ) on IL-1beta induced IL-8 production by the human intestinal epithelial cell line HT-29
Lewis et al., Mol Cell Biol 1994 : Mutational analysis of the -127/-118 NF-kappa B site indicates that both NF-kappa B and HMG-I(Y) binding at this site are essential for interleukin-1 induction of the promoter
Wu et al., FEBS Lett 2002 : In HEK293 cells, proteasome inhibitors could concentration-dependently increase IL-8 promoter and activator protein-1 (AP-1) activities, but inhibited nuclear factor (NF)-kappa B activation induced by cytokines
Yeh et al., J Biol Chem 2004 (Inflammation) : We have shown recently that Ox-PAPC mediated induction of IL-8 transcription is independent of NF-kappaB activation, a major transcription factor utilized by cytokines and lipopolysaccharide for the induction of IL-8 transcription
Holden et al., Br J Pharmacol 2007 : Using BEAS-2B bronchial epithelial cells, NF-kappaB dependent transcription and both release and mRNA expression of IL-6 and IL-8 were examined by reporter assay, ELISA and quantitative RT-PCR ... Similarly, H ( 3 ) and H ( 4 ) receptor agonists did not affect TNFalpha induced NF-kappaB dependent transcription, or IL-6 and IL-8 release at concentrations below 10 microM ... The anti-inflammatory glucocorticoid, dexamethasone, inhibited the histamine enhanced NF-kappaB dependent transcription and IL-6 and IL-8 release
Dragneva et al., Infect Immun 2001 : Subcytocidal attack by staphylococcal alpha-toxin activates NF-kappaB and induces interleukin-8 production
Le et al., J Interferon Cytokine Res 2000 (Adenocarcinoma...) : Collectively, our data demonstrated that constitutive NF-kappaB and AP-1 activation contributes to the overexpression of IL-8 , which in turn plays an important role in tumor angiogenesis and contributes to the aggressive biology of human pancreatic cancer
Pei et al., Cytokine 2002 : Asbestos exposure and particulate air pollution have been reported to stimulate the expression of IL-8 and to induce NF-kappaB activation ... We have assessed the effect of adenovirus mediated overexpression of the NF-kappaB inhibitor, IkappaBalpha on PAH induced IL-8 expression in A549 cell line ... This suggests that PAH induced IL-8 gene regulation may be mediated by NF-kappaB
Cogswell et al., J Biol Chem 2003 : Stimulation of cells with inflammatory cytokines such as tumor necrosis factor alpha or interleukin-1 induces the degradation of I kappa B, the inhibitor of NF-kappa B , allowing nuclear accumulation of NF-kappa B and regulation of specific gene expression
Patel et al., J Interferon Cytokine Res 2002 (Melanoma) : These results demonstrate that constitutive and induced NF-kappaB activation regulates IL-8 expression in melanoma cells ... Downregulation of constitutive and induced NF-kappaB activation in malignant melanoma cells leads to inhibition of IL-8 production and in vitro cell proliferation
Morel et al., Lab Invest 2001 (Arthritis, Rheumatoid) : IL-18 induces IL-8 secretion through NFkappaB because RA synovial fibroblasts pretreated with antisense to NFkappaB p65 oligonucleotide produce a mean of 44 % less IL-8 compared with cells pretreated with the control sense oligonucleotide
Wang et al., Infect Immun 2001 : Dominant negative myeloid differentiation protein ( MyD88 ), IL-1 receptor associated kinase (IRAK), NFkappaB inducing kinase (NIK), and IkappaB kinase (IKK) mutant forms completely inhibited micrococcus- and PGN induced activation of NF-kappaB and expression of the gene for IL-8 ... These data indicate that micrococci and PGN induce TLR2 dependent activation of the gene for IL-8 and that this activation requires MyD88, IRAK, NIK, IKK, and NF-kappaB and may also utilize TRAF6 and, to a lesser extent, TRAF2
Wang et al., Exp Eye Res 2010 : Treatment of ARPE-19 cells with CRP resulted in enhanced NF-kB nuclear translocation and dose dependent transient induction of IL-8 mRNA synthesis and protein secretion
Wijagkanalan et al., Mol Pharmacol 2008 (Pneumonia) : DPML significantly inhibited tumor necrosis factor alpha, interleukin-1beta , and cytokine induced neutrophil chemoattractant-1 levels, suppressed neutrophil infiltration and myeloperoxidase activity, and inhibited NFkappaB and p38 mitogen activated protein kinase activation in the lung
Chavey et al., Mol Pharmacol 2008 (Breast Neoplasms) : In summary, our results demonstrate that NF-kappaB pathway repression by HDAC is responsible for the low expression of IL-8 in ERalpha positive breast cancer cells
Kim et al., J Immunol 2000 : We evaluated the role of NF-kappaB in HRV-16 induced IL-8 and IL-6 production by EMSA using oligonucleotides corresponding to the binding sites for NF-kappaB in the IL-6 and IL-8 gene promoters ... Thus, HRV-16 induces epithelial expression of IL-8 and IL-6 by an NF-kappaB independent pathway, whereas induction of GM-CSF is at least partially dependent upon NF-kappaB activation
Huang et al., Cytokines Cell Mol Ther 2000 (Lung Neoplasms...) : The purpose of this study was to determine whether constitutive NF-kappaB activity regulates the expression level of interleukin-8 (IL-8) in metastatic human melanoma cells ... Transfection of melanoma cells with a dominant negative mutant IkappaBalpha expression vector ( pLXSN-IkappaBalphaM ) significantly decreased the level of constitutive NF-kappaB activity and expression of IL-8, demonstrating that constitutive NF-kappaB/relA activities contribute to overexpression of IL-8 in highly metastatic human melanoma cells
Szczepanski et al., Cancer Res 2009 (Carcinoma, Squamous Cell...) : LPS binding to TLR4 on tumor cells enhanced proliferation, activated phosphatidylinositol 3-kinase/Akt pathway, up-regulated IRAK-4 expression, induced nuclear NF-kappaB translocation, and increased production ( P < 0.05 ) of interleukin (IL)-6, IL-8 , vascular endothelial growth factor, and granulocyte macrophage colony stimulating factor
Kwon et al., Mol Cell Biol 2004 : Signaling molecule that interacts with mouse pelle-like kinase ( SIMPL ) is a signaling component required for tumor necrosis factor alpha (TNF-alpha) dependent but not interleukin-1 dependent NF-kappaB activation
Li et al., Am J Physiol Lung Cell Mol Physiol 2002 (MAP Kinase Signaling System) : Recent studies indicate that maximal IL-8 protein expression requires activation of NF-kappaB as well as activation of the MAP kinases ERK, JNK, and p38
Gao et al., Cell Mol Life Sci 2009 : Transforming growth factor-beta activated kinase 1 ( TAK1 ) is a serine/threonine protein kinase that is critically involved in the activation of NF-kappaB by tumor necrosis factor ( TNFalpha ), interleukin-1beta (IL-1beta) and TLR ligands
Natarajan et al., J Interferon Cytokine Res 2001 (Crohn Disease) : Redox imbalance in Crohn 's disease intestinal smooth muscle cells causes NF-kappaB mediated spontaneous interleukin-8 secretion
Bhaumik et al., Oncogene 2008 (Breast Neoplasms...) : Impaired NF-kappaB activity was evident from reduced phosphorylation of the NF-kappaB inhibitor IkappaBalpha, reduced NF-kappaB DNA binding activity and suppressed expression of the NF-kappaB target genes IL-8 , IL-6 and matrix metalloproteinase-9
Zhang et al., Curr Eye Res 2005 : Presence of the NF-kappaB inhibitor kamebakaurin in culture medium blocked P. aeruginosa induced NF-kappaB activation and inhibited IL-6, IL-8 , and TNF-alpha expression and secretion
Kim et al., Int Immunol 2005 (MAP Kinase Signaling System) : Moreover, inhibitors of MAPK ( U0126 and SB203580 ) significantly reduced the IL-8 production, while the inhibition of NF-kappaB ( pyrrolidinedithiocarbamate and retrovirus containing dominant negative IkappaB alpha plasmid ) did not affect the IL-8 expression increased by CpG ODN
Seo et al., J Physiol Pharmacol 2009 : Nitric oxide induced IL-8 expression is mediated by NF-kappaB and AP-1 in gastric epithelial AGS cells
He et al., Zhonghua Yi Xue Za Zhi 2001 (Pulmonary Disease, Chronic Obstructive) : Enhancement of activity of NF kappa B and AP-1 may positively regulate the production of IL-8 and IL-1 beta in the airflow obstruction
Chen et al., Biorheology 2003 (Mechanotransduction, Cellular) : The induction of IL-8 gene expression by laminar shear stress is probably due to the activation of NF-kappaB
Qian et al., J Biol Chem 2001 : IRAK mediated translocation of TRAF6 and TAB2 in the interleukin-1 induced activation of NFkappa B
Hara et al., Molecular vision 2009 : Hypoxia also attenuated both the LPS induced expression of IL-6 and IL-8 , and the activation of NFkappaB in SV40-HCECs
Manna et al., Clin Cancer Res 2007 (Inflammation...) : We showed by DNA binding assay that NF-kappaB activation induced by tumor necrosis factor (TNF), phorbol 12-myristate 13-acetate, lipopolysaccharide, ceramide, interleukin-1 , and H ( 2 ) O ( 2 ) was suppressed by morin ; the suppression was not cell type specific
Zhao et al., J Biol Chem 2001 (Colonic Neoplasms...) : By using reporter gene constructs containing targeted substitutions in the IL-8 promoter, we show that the NF-kappaB , AP-1, and to a lesser degree the C/EBP sites in the IL-8 promoter region are required for IL-8 gene expression induced by NT
Jamaluddin et al., Cell Signal 2007 : These results indicate that the ROS mediated TNF-alpha induced IL-8 transcription is regulated by NF-kappaB/RelA phosphorylation at the critical Ser ( 276 ) residue by PKAc, resulting in stable enhanceosome formation on target genes
Jefferson et al., J Immunol 1999 (Calcium Signaling) : NF-kappa B inhibitors blocked the ability of toxin A to induce IL-8 secretion, and supershift analysis indicated that the major isoform of NF-kappa B activated by the toxin is a p50-p65 heterodimer
Wachter et al., J Biol Chem 2004 (Inflammation) : Surprisingly, cFLIP ( L ) specifically blocked TRAIL induced NF-kappaB activation and TRAIL dependent induction of the proinflammatory target gene interleukin-8
Seppänen et al., Oncol Res 1998 (Adenocarcinoma...) : In the present study, we have investigated the effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ), interleukin-10 (IL-10) and -13 ( IL-13 ), transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors AP-1 and NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro
Ho et al., J Immunol 2009 : In contrast, NE did not induce NRF expression in A549 and Beas-2B cells, where NE only stimulates NF-kappaB activation and IL-8/CXCL8 induction
Takeuchi et al., Antioxid Redox Signal 2000 : Thioredoxin inhibits tumor necrosis factor- or interleukin-1 induced NF-kappaB activation at a level upstream of NF-kappaB inducing kinase
Fickl et al., Clin Exp Immunol 2005 (Hemolysis) : Exposure of neutrophils to pneumolysin was accompanied by influx of Ca ( 2+ ), activation of NFkappaB , and synthesis of IL-8 , all of which were eliminated by inclusion of the Ca ( 2+ ) -chelating agent, EGTA ( 10 m m ), in the cell suspending medium, as well as by pretreatment of the cells with docosahexaenoic acid ( 5 and 10 microg/ml )
De Valck et al., Biochem Biophys Res Commun 1997 : However, A20 mutants that no longer associated with 14-3-3 proteins could still fully inhibit NF-kappaB activation induced by tumor necrosis factor, interleukin-1beta or phorbol 12-myristate 13-acetate, thus excluding a crucial role for 14-3-3 interaction in this A20 function
Cho et al., EMBO J 2009 : An acetylation-deficient cyclin T1 mutant dominantly suppresses NF-kappaB mediated activation of the interleukin-8 promoter but continues to synergize normally with the HIV Tat protein to transactivate the HIV long terminal repeat
Scholz et al., Cardiovasc Res 2003 (Inflammation...) : Furthermore, the ERK 1/2 inhibitor, PD98059, and the p38 MAPK inhibitor, SB203580, markedly reduced 8-isoprostane induced IL-8 expression ( mRNA and protein ), while inhibition of NF-kappaB activation and translocation had no significant effect on IL-8 expression
Tahan et al., Clin Exp Allergy 2008 : TNF-alpha induced IL-8 release was suppressed by an NF-kappaB inhibitor but not by MEK or p38 MAPK inhibitors
Tang et al., J Clin Invest 2003 : NF-kappaB activation and IL-8 secretion were attenuated by the NF-kappaB inhibitors pyrrolidine dithiocarbamate and cell-permeable peptide
Shembade et al., J Virol 2007 : Mouse fibroblasts lacking Ubc13 exhibit impaired Tax activation of NF-kappaB despite normal tumor necrosis factor- and interleukin-1 mediated NF-kappaB activation
Neff et al., Cell Microbiol 2001 (Arthritis, Rheumatoid...) : Our experiments also indicated that stimulation of FLSs with protein I/II induces nuclear translocation of NF-kappaB, AP-1 binding activity and that NF-kappaB plays a major role in IL-6 and IL-8 secretion from activated cells
Frey et al., Ann Rheum Dis 2013 (Arthritis, Psoriatic...) : Functionally, IL-36a induced the expression of IL-6 and IL-8 in FLS through p38/NFkB activation
Kuroiwa et al., Biochem Biophys Res Commun 2009 : Moreover, inhibition of NF-kappaB signaling suppressed IL-8 mRNA expression induced by bacterial neuraminidase
Wullaert et al., J Biol Chem 2007 : Similar to the other ABINs, ABIN-3 binds to A20 and inhibits NF-kappaB activation induced by tumor necrosis factor, interleukin-1 , and 12-O-tetradecanoylphorbol-13-acetate
Raychaudhuri et al., Clin Immunol 2002 (Hypertension, Pulmonary) : However, mRNA expression was decreased compared to controls for NF-kappaB regulated genes, granulocyte macrophage colony stimulating factor, interleukin-6 , macrophage inflammatory protein-1alpha ( MIP-1alpha ), and vascular endothelial growth factor
Friedman et al., J Virol 2002 : We demonstrate here that the E3 region of Ad inhibits the activation of NF-kappa B induced by tumor necrosis factor alpha (TNF-alpha) and interleukin-1
Onodera et al., Arthritis Rheum 2004 (Arthritis, Rheumatoid...) : The mRNA up-regulation of IL-8 and IL-1beta by MIF was inhibited by 2 tyrosine kinase inhibitors, a protein kinase C ( PKC ) inhibitor, an activator protein 1 (AP-1) inhibitor, and by an NF-kappaB inhibitor
Wolf et al., Clin Cancer Res 2001 (Carcinoma, Squamous Cell...) : In this study, we examined the role of IL-1alpha in the activation of NFkappaB and AP-1, the expression of proangiogenic cytokine IL-8 , and in the survival and proliferation of HNSCC cell lines ... IL-1alpha was found to induce coexpression of IL-8 through the activation of NFkappaB and AP-1, in that mutation of the NFkappaB site within the IL-8 promoter abolished autocrine- and recombinant IL-1alpha induced IL-8 reporter gene activity, whereas mutation in AP-1 partially decreased IL-8 reporter gene activity in UM-SCC-9 cells
Giri et al., J Biol Chem 1998 (Lymphoma, T-Cell...) : HuT-78 cells were also resistant to NF-kappaB activation induced by phorbol ester, H2O2, ceramide, endotoxin, and interleukin-1
Shin et al., Immunopharmacol Immunotoxicol 2009 (Inflammation) : MW inhibited secretion of TNF-alpha, IL-6, and IL-8 possibly by inhibiting NF-kappaB activation
Hong et al., Scand J Immunol 2010 : Through ERK inhibitor ( U0126 ) and NF-kB inhibitor ( caffeine acid phenethyl ester ) treatment, it was proven that ERK and NF-kB regulated chitinase induced IL-8 expression
LaVallie et al., J Biol Chem 2006 (Osteoarthritis) : Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes
Chang et al., Experimental biology and medicine (Maywood, N.J.) 2009 : Further studies showed that G308S could increase the phosphorylation of ERK and the translocation of NF-kappaB into the nucleus, and the inhibition of ERK phosphorylation decreased the IL-8 production, mRNA expression and activation of NF-kappaB
Rasmussen et al., Inflamm Res 2008 (Inflammation) : We studied NF-kappaB activation and the induction of interleukin 8 (IL-8) and p53 gene expression in an interleukin 1beta (IL-1beta) stimulated HepG2 cell line ... NF-kappaB induced IL-8 and p53 protein production was studied using specific siRNA, an IkappaB kinase 2 inhibitor, and mitogen activated protein kinase ( MAPK ) inhibitors
Bancroft et al., Int J Cancer 2002 (Carcinoma, Squamous Cell...) : Recombinant EGF induced EGFR phosphorylation, activation of NF-kappaB and AP-1 reporter genes and IL-8 and VEGF expression, indicating that EGFR can mediate coactivation of both transcription factors and cytokine genes in HNSCC
Guo et al., Free Radic Biol Med 2008 : CH3-Avn-c, a synthetically prepared methyl ester derivative of Avn-c with a high biological potency, significantly and dose dependently decreased mRNA expression and secretion of IL-6, IL-8 , and MCP-1 by HAEC as determined by real-time RT-PCR and ELISA, and it inhibited IL-1beta- and TNFalpha stimulated NF-kappaB activation as determined by a NF-kappaB DNA binding assay and a NF-kappaB luciferase reporter assay
Zhao et al., J Biol Chem 2007 (Inflammation) : Lauric acid ( C12 : 0 ) dose dependently activated NF-kappaB and induced IL-8 expression in HCT116 cells, which express both Nod1 and Nod2, but not detectable amounts of TLR2 and TLR4
Hauf et al., J Immunol 2003 (Inflammation) : As a consequence of NF-kappaB suppression, wild-type STEC induces significantly lower mRNA levels of IL-8 , IL-6, and IL-1alpha upon prolonged infection periods compared with bacteria lacking EspB
Li et al., Am J Physiol Lung Cell Mol Physiol 2003 (MAP Kinase Signaling System) : Stretch also induced NF-kappaB inducing kinase (NIK) activation, and inhibition of NF-kappaB attenuated IL-8 mRNA expression and IL-8 production
Rogler et al., Scand J Gastroenterol 2001 (Colitis, Ulcerative...) : The induction of IL-8 , M-CSF and GM-CSF, but not of IL-6 secretion, is mediated mainly by NF-kappaB activation
Smith et al., J Immunol 2001 : IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2 ... It was found that the DNA region between nucleotides -1481 and -546 and the transcription factor NF-kappaB were essential for the maximal induction of IL-8 by 3-O-C12-HSL
Bates et al., Exp Cell Res 2004 (Colonic Neoplasms...) : Using a novel model of EMT in colon carcinoma in which the inflammatory cytokine TNF-alpha accelerates this TGF-beta directed process, we report that TNF-alpha stimulation upregulates expression of the chemokine IL-8 , and that this upregulation is dependent on the transcription factor NF-kappaB
Ng et al., J Biol Chem 1994 : Although tumor necrosis factor (TNF) and interleukin-1 ( IL ) induce the expression of the IL-8, TNF stimulated gene 6, and plasminogen activation inhibitor-2 genes and the activation of NF-kappa B with nearly identical kinetics, the two cytokines differ significantly in the induction of the IL-6 gene in all primary fibroblasts tested
Fiedler et al., J Virol 1999 : Respiratory syncytial virus ( RSV ) infection of airway epithelial cells results in persistent NF-kappaB activation and NF-kappaB mediated interleukin-8 production
Piccagli et al., BMC structural biology 2008 : In this respect, this paper represents the first example of successfully individuation through molecular docking simulations of a promising lead compound for the inhibition of NF-kappaB-p50 biological activity and modulation of the expression of the NF-kB regulated IL8 gene
Maurais et al., Virology 2009 (HIV Infections) : Importantly, we show that wild-type CD40L remains functional since CD40L bearing virions mediate NF-kappaB activation in a CD40 expressing reporter cell line and induce secretion of the chemokine IL-8 by monocyte derived macrophages
Dasu et al., Diabetes 2008 : High glucose increased TLR expression, myeloid differentiation factor 88, interleukin-1 receptor associated kinase-1, and nuclear factor-kappaB (NF-kappaB) p65 dependent activation in THP-1 cells
Karagiannides et al., Proc Natl Acad Sci U S A 2006 (Colitis) : Moreover, human mesenteric preadipocytes transfected with a luciferase promoter/reporter system containing the IL-8 promoter with a mutated NF-kappaB site lost their ability to respond to SP, indicating that SP-induced IL-8 expression is NF-kappaB dependent
Kustermans et al., Biochem Pharmacol 2008 : Actin cytoskeleton differentially modulates NF-kappaB mediated IL-8 expression in myelomonocytic cells
Yang et al., Mol Immunol 2008 (Escherichia coli Infections...) : Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-kappaB in mammary epithelial cells and to quickly induce TNFalpha and interleukin-8 ( CXCL8 ) expression in the udder
Lee et al., Immunology 2005 (Intestinal Diseases...) : Furthermore, BAY11-7082, an inhibitor of NF-kappaB activation, significantly reduced the IL-8 production, NF-kappaB binding activity and IkappaB-alpha degradation induced by V. vulnificus infection
Boost et al., Int J Mol Med 2009 : We, therefore, aimed to investigate the effects of the volatile anesthetics sevoflurane and isoflurane on NF-kappaB/IkappaBalpha dependent intracellular signal transduction in human monocytic THP-1 cells induced by tumor necrosis factor-alpha (TNF-alpha) and production of interleukin-8 (IL-8) and downstream heme oxygenase-1 (HO-1)
Choi et al., Atherosclerosis 2010 : This study suggests that GSA induces expression of IL-8 in VSMCs and that TLR-4, mitogen activated protein kinases, NF-kappaB , and NADPH oxidase are involved in that process
Martin et al., J Biol Chem 2009 : Furthermore, we identified the components of the CBM complex, Carma3, Bcl10, and Malt1, as key mediators of the CXCL8/IL8 induced NFkappaB activation and VEGF up-regulation
Carmona et al., Respir Res 2010 (Calcium Signaling) : Our data provide evidence that PCBG induces phosphorylation of the MAPKs, ERK, and p38, the activation of NF-kappaB and the subsequently secretion of IL-8 in a calcium dependent manner
Delgado et al., Biochem Biophys Res Commun 2003 (Inflammation) : VIP seems to act by inhibiting the NF-kappaB dependent IL-8 gene activation
Hajishengallis et al., Infect Immun 2004 (Inflammation) : In this regard, the ability of LT-IIbB to activate NF-kappaB and induce TNF-alpha and IL-8 was antagonized by the LT-IIb holotoxin
Zouki et al., J Leukoc Biol 2001 : The NO synthase inhibitors aminoguanidine and N ( G ) -nitro-L-arginine methyl ester blocked nuclear accumulation of activator protein-1 (AP-1) and nuclear factor (NF)-kappaB in both polymorphonuclear ( PMN ) and mononuclear leukocytes and inhibited IL-8 mRNA expression and IL-8 release by approximately 90 % in response to IL-1beta and TNF-alpha
Fong et al., J Bone Miner Res 2008 (Neoplasms) : Activation of AP-1 and NF-kappaB DNA-protein binding and MAPKs after TGF-beta1 treatment was shown, and TGF-beta1 induced IL-8 promoter activity was inhibited by the specific inhibitors of MAPK cascades
Nomi et al., Invest Ophthalmol Vis Sci 2010 : The zymosan induced release of IL-6 and IL-8 was attenuated by inhibitors of ERK, p38, JNK, and NF-kappaB signaling
Wu et al., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2001 : and Their time courses were similar, thus suggesting that the induction of IL-8 gene expression by TNF-alpha is probably due to the activation of NF-kappa B
Jandhyala et al., Infect Immun 2010 (Escherichia coli Infections) : Using reporter gene constructs, we showed that flagellin mediated interleukin-8 gene transcription is heavily dependent on both NF-kappaB and extracellular signal regulated kinase 1 and 2 ( ERK-1/2 ) activation
Lixuan et al., Pulm Pharmacol Ther 2010 (Disease Models, Animal...) : The results show that CSE resulted in increasing IL-8 , IL-6 and TNF-alpha expression and activation of NF-kappaB
Hoyle et al., Am J Physiol Lung Cell Mol Physiol 2010 (Pneumonia) : Triptolide inhibited IL-8 production induced by substance P with an IC ( 50 ) of 2.3 x 10 ( -8 ) M and inhibited NF-kappaB activation in response to an agonist of the protease activated receptor 2 with an IC ( 50 ) of 1.4 x 10 ( -8 ) M. Anti-inflammatory effects of triptolide were assessed in vivo using a chlorine gas lung injury model in mice
Zheng et al., Infect Immun 2008 : Campylobacter induced interleukin-8 secretion in polarized human intestinal epithelial cells requires Campylobacter secreted cytolethal distending toxin- and Toll-like receptor mediated activation of NF-kappaB
Hong et al., Vascul Pharmacol 2009 : The present study reports that TLR-4-agonistic LPS upregulates IL-8 at the transcriptional and post-translational level in VSMCs, and that ERK1/2, NF-kappaB , and C/EBP play major roles in the upregulation of IL-8
Dahan et al., Infect Immun 2002 (Escherichia coli Infections) : These findings demonstrate that ( i ) EHEC can induce in vitro a potent proinflammatory response by secretion of IL-8 and ( ii ) the secretion of IL-8 is due to the involvement of MAPK, AP-1, and NF-kappaB signaling pathways
Knobil et al., Am J Physiol 1998 (Lung Neoplasms) : Pretreatment of A549 cells with N-acetyl-L-cysteine attenuated virus induced NF-kappa B activation and interleukin (IL)-8 mRNA induction but did not block induction of MnSOD mRNA
Sougioultzis et al., Biochem Biophys Res Commun 2006 : Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB mediated IL-8 gene expression ... The probiotic yeast Saccharomyces boulardii exerts an anti-inflammatory effect by producing a low molecular weight soluble factor that blocks NF-kappaB activation and NF-kappaB mediated IL-8 gene expression in intestinal epithelial cells and monocytes
Takada et al., J Biol Chem 2004 : PTD-p65-P1 suppressed NF-kappaB activation induced by lipopolysaccharide, interleukin-1 , okadaic acid, phorbol 12-myristate 13-acetate, H ( 2 ) O ( 2 ), and cigarette smoke condensate as well as that induced by TNF
Kim et al., Scand J Gastroenterol 2001 (Adenocarcinoma...) : We studied the role of NF-kappaB on expression of IL-8 and COX-2 in H. pylori stimulated AGS gastric epithelial cells by using antisense oligonucleotide ( AS ODN ) for NF-kappaB subunit p50 and an antioxidant, glutathione ( GSH ) as well as a NF-kappaB inhibitor, pyrrolidine dithiocarbamate ( PDTC ) ... NF-kappaB may play a novel role in expression of IL-8 and COX-2 in H. pylori induced gastric inflammation
Lee et al., Biochim Biophys Acta 2009 : DSCR1-1S also stimulated IL-1R mediated signaling pathways, TAK1 activation, NF-kappaB transactivation , and IL-8 production, all downstream consequences of IL-1R activation
Schwager et al., Vet Immunol Immunopathol 1998 (Ascorbic Acid Deficiency...) : The results suggest that ascorbate levels exert an early effect on immune homeostasis via reactive oxygen intermediates ( ROI ) -dependent expression of interleukin genes, since the transcription factor NF-kappa B is sensitive to ROI and regulates the expression of interleukin genes
Wang et al., Zhonghua Gan Zang Bing Za Zhi 2011 (Carcinoma, Hepatocellular...) : p38 MAPK inhibitor ( SB203580 ) could significantly inhibit IL-8 production in a dose dependent manners ( F = 65.47, P < 0.01 ), and partially inhibited NF-kB p65 nuclear translocation in a dose dependent manner ( F=141.20, P < 0.05 )
Bradbury et al., Cancer Res 2001 : Recently, it also has been demonstrated that nonsteroidal anti-inflammatory agents inhibit tumor necrosis factor and interleukin-1 induced NF-kappaB activation and act as radiosensitizing agents
Huang et al., J Virol 2002 : The IL-8 promoter is regulated by NF-kappaB/p65 in response to tumor necrosis factor alpha and requires the cooperation of the coactivators CBP/p300 and steroid receptor coactivator 1 (SRC-1) and the p300/CBP associated factor (P/CAF) for optimal activation
Shaneyfelt et al., Virology journal 2006 : Two of these four compounds, alpha-mangostin and 18-beta-glycyrrhetinic acid, activated NFkappaB and induced IL-8 secretion
Zhao et al., J Cell Biochem 2006 (Colitis...) : In addition, ghrelin stimulated NF-kappaB binding activity and NF-kappaB p65 subunit phosphorylation, and induced IL-8 promoter activity and IL-8 protein secretion
Raymond et al., PLoS Pathog 2009 (Pneumonia) : We demonstrate that although NF-kappaB is essential for IL-8 expression, LT downregulates this expression without interfering with NF-kappaB activation in epithelial cells
Joshi-Barve et al., Hepatology 2003 : This increase in IL-8 is independent of nuclear factor kappaB (NF-kappaB) activation and is associated with an increase in c-Jun N-terminal kinase (JNK) and activator protein-1 (AP-1) activity
Kim et al., J Ethnopharmacol 2009 (Inflammation) : ACL also inhibited expression of IL-8 and activation of NF-kappaB following PGN induction
Choi et al., Mol Cell Biol 2002 (Astrocytoma...) : These findings collectively indicate that DR5 ligation on human glioma cells leads to apoptosis and that the activation of AP-1 and NF-kappaB leads to the induction of IL-8 expression ; these responses are dependent on caspase activation
Sarir et al., Biochem Pharmacol 2010 (Emphysema) : Preincubation of the cells with antioxidants, such as N-acetyl-L-cysteine (NAC), prevented the overproduction of IL-8 and activation of NF-kappaB
Lakshmanan et al., J Immunol 2007 : Caspase-4 interacts with TNF receptor associated factor 6 and mediates lipopolysaccharide induced NF-kappaB dependent production of IL-8 and CC chemokine ligand 4 ( macrophage-inflammatory protein-1 ) ... Because a specific NF-kappaB inhibitor blocked LPS induced IL-8 and CCL4 mRNA expression as well as IL-8 and CCL4 secretion in THP1 cells, we investigated the role of caspase-4 in NF-kappaB signaling
Hsu et al., Blood 1999 : NF-kappaB activation is required for C5a induced interleukin-8 gene expression in mononuclear cells ... These results suggest that NF-kappaB activation is required for C5a induced IL-8 gene expression and that this response is mediated primarily through a pertussis toxin-insensitive pathway
Regueiro et al., Eur Respir J 2009 : LBP and sCD14 inhibited the nontypeable Haemophilus influenzae ( NTHi ) -dependent secretion of IL-8 and the activation of NF-kappaB and p38 mitogen activated protein kinase signalling pathways but they increased the internalisation of NTHi by airway epithelial cells
Zeng et al., Acta Pharmacol Sin 2005 : Inhibitors of PKC ( calphostin C, 50-500 nmol/L and RO-31-8220, 10-100 nmol/L ), CaM ( W7, 28-280 micromol/L ), ERK1/2 MAPK ( PD 98059, 2-20 micromol/L ), p38 MAPK ( SB 203580, 0.6-6 micromol/L ), JNK MAPK ( curcumin, 2-10 micromol/L ), and NF-kappaB ( PDTC, 10-100 nmol/L ) markedly reduced Hcy 100 micromol/L induced production of MCP-1 and IL-8 in human cultured whole blood, but the inhibitors of PTK ( genistein, 2.6-26 micromol/L and tyrphostin, 0.5-5 micromol/L ) had no obvious effect on MCP-1 and IL-8 production
Bartels et al., J Immunol 2007 (Helicobacter Infections) : Peptide mediated disruption of NFkappaB/NRF interaction inhibits IL-8 gene activation by IL-1 or Helicobacter pylori ... Previous studies suggested that interaction of transcription factors NFkappaB repressing factor (NRF) and NFkappaB play a crucial role in activation of IL-8 gene expression
Gri et al., J Biol Chem 1998 (Cell Transformation, Viral) : Synergistic regulation of the human interleukin-12 p40 promoter by NFkappaB and Ets transcription factors in Epstein-Barr virus transformed B cells and macrophages
Mastronarde et al., J Infect Dis 1996 : Induction of interleukin (IL)-8 gene expression by respiratory syncytial virus involves activation of nuclear factor (NF)-kappa B and NF-IL-6
Peng et al., Exp Cell Res 2007 (Inflammation...) : Furthermore, the production of IL-8 in PMNs is NF-kappaB dependent
Masamune et al., Gastroenterology 1999 (Helicobacter Infections...) : This effect was mimicked by sphingomyelinase, but not by phospholipase A2 or phospholipase C. C2-ceramide induced IL-8 gene transcription mainly through activation of NF-kappaB because mutation of the NF-kappaB binding site completely abrogated the induction of luciferase activity
Fisette et al., J Biol Chem 2003 : We found the purified preparation of Lip to be a potent inflammatory mediator capable of inducing the release of the chemokine interleukin (IL)-8 and the cytokine IL-6 by immortalized human endocervical epithelial cells and the production of IL-8 and the activation of the transcription factor NF-kappaB by human embryonic kidney 293 (HEK) cells transfected with toll-like receptor (TLR) 2
Kim et al., Mol Pharmacol 2008 (Inflammation...) : BOT-64 attenuates NF-kappaB regulated expression of inflammatory genes such as inducible nitric-oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha, interleukin (IL)-1beta , and IL-6 in LPS activated or expression vector IKKbeta transfected macrophages
Scheinman et al., Mol Cell Biol 1995 : In HeLa cells, DEX activation of endogenous GR is sufficient to block tumor necrosis factor alpha or interleukin 1 activation of NF-kappa B at the levels of both DNA binding and transcriptional activation
Schulte et al., FASEB J 2000 : Invasin induced NF-kappaB activation correlated with degradation of IkappaBalpha and the inhibition of NF-kappaB by specific inhibitors of IkappaB activation blocked invasin induced IL-8 secretion
Blanchard et al., Dig Dis Sci 2001 (Adenocarcinoma...) : Previously, we have demonstrated that tumor necrosis factor-alpha (TNF-alpha) and gram negative bacterial lipopolysaccharide stimulate production of IL-6 and IL-8 and activation of the transcription factor NF-kappaB in the well differentiated pancreatic ductal adenocarcinoma cell lines CAPAN-1 and CAPAN-2
Gewirtz et al., J Clin Invest 2000 : IL-8 secretion induced by both the prototypical proinflammatory cytokine TNF-alpha and S. typhimurium was NF-kappaB dependent
Mayet et al., Eur J Clin Invest 1999 (Wegener Granulomatosis) : In addition, we established that the activation of NF-kappaB is critically involved in anti-PR-3 antibody induced endothelial IL-8 production
Cho et al., Infect Immun 2001 : The induction of MCP-1 and IL-8 transcripts in the endothelial cells by O. tsutsugamushi was not blocked by the inhibitors of NF-kappaB
Paik et al., Lab Invest 2006 (Fibrosis...) : TNF-alpha and IL-1beta significantly upregulated the expression of TLR2 mRNA and protein in HSCs. PGN and LTA induced NF-kappaB activation and stimulated production of IL-8 in HSCs. Pretreatment with TNF-alpha or IL-1beta augmented NF-kappaB activation and IL-8 production in response to PGN or LTA
Park et al., Cell Biol Int 2008 (Colonic Neoplasms) : To clarify the role of NF-kappaB on IL-8 expression in echinomycin mediated apoptosis of HT-29 cells, ELISA plus RT-PCR clearly showed that IL-8 production is inducible by echinomycin treatment
Lin et al., J Immunol 2005 : The expression of IL-6, IL-8 , and MCP-1 was blocked by the preabsorption of anti-DV NS1 with DV NS1 or by the inhibition of NF-kappaB activation
Mühlbauer et al., Am J Physiol Gastrointest Liver Physiol 2004 : Our data suggest that DCA induced signal transduction mainly utilized the I kappa B degradation and RelA nuclear translocation pathway, whereas TDCA primarily induced IL-8 gene expression through RelA phosphorylation
Mitsuyama et al., J Bone Miner Res 2004 (Calcium Signaling) : It was demonstrated that Ca2+ signaling pathway involving calcineurin regulates IL-8 gene expression through activation of a transcription factor, NF-kappaB
Manna et al., J Cell Physiol 2006 : Phospholipids significantly protected oleandrin mediated inhibition of IL-8 binding thereby restoring IL-8 induced NF-kappaB activation
Sun et al., Nature 2000 : Activation of NF-kappaB by tumour-necrosis factor alpha and interleukin-1 was unaffected in the mutant mice
Ishihara et al., J Immunol 2004 (Gastritis...) : NF-kappaB activation and activation of IL-8 and MD-2 promoters were assessed by reporter gene assay
Rafiee et al., Am J Physiol Gastrointest Liver Physiol 2009 : Together, these data demonstrate that 1 ) acid is a potent inducer of IL-6 and IL-8 production in HET-1A cells ; 2 ) MAPK and PKC signaling play a key regulatory role in acid mediated IL-6 and IL-8 expression via NF-kappaB activation ; and 3 ) the anti-inflammatory plant compound curcumin inhibits esophageal activation in response to acid
Ahn et al., J Biol Chem 2007 : Besides TNF, gamma-tocotrienol also abolished NF-kappaB activation induced by phorbol myristate acetate, okadaic acid, lipopolysaccharide, cigarette smoke, interleukin-1beta , and epidermal growth factor
Hastings et al., Arterioscler Thromb Vasc Biol 2009 (Atherosclerosis) : Additionally, IL-8 reduced p38 activation and NF-kappaB activity induced by IL-1beta alone
Bruno et al., Mucosal Immunol 2011 : Whereas induction of proinflammatory genes such as interleukin-8 (IL-8) required only RelA , pIgR expression was regulated by complex mechanisms that involved both RelA and RelB
Zhou et al., Virology journal 2007 : These results suggest that E1Blarge interacts with NF-kappaB to prevent transcription and down regulate proinflammatory cytokine IL-8 production
Pena et al., Infect Immun 2009 : P. aeruginosa strain PAK DeltafliC ( flagellin knockout ) did not activate NF-kappaB or interleukin-8 (IL-8) but inhibited flagellin activated NF-kappaB by 40 to 50 % and IL-8 secretion by 20 to 25 %
Xiao et al., J Biol Chem 2008 : Pellino 3b negatively regulates interleukin-1 induced TAK1 dependent NF kappaB activation
Varney et al., In Vivo 2002 (Melanoma...) : The differential expression of IL-8 by monocytes following MCP-1 and M-CSF treatments involved activation of the NFkB transcription factor
Bancroft et al., Clin Cancer Res 2001 (Carcinoma, Squamous Cell...) : Expression of IL-8 and VEGF in the cell lines was associated with coactivation of both NF-kappaB and AP-1, and U0126 inhibited both NF-kappaB and AP-1 reporter activity in UM-SCC-9 and UM-SCC-11B cells
Wu et al., Infect Immun 2004 : Our data suggest that BFT stimulated IL-8 secretion involves tyrosine kinase dependent activation of nuclear factor-kappaB (NF-kappaB) as well as activation of the mitogen activated protein kinases ( MAPKs ), p38 and extracellular signal related kinase ... Simultaneous activation of NF-kappaB and MAPKs appears necessary for secretion of IL-8 by HT29/C1 cells treated with BFT
Fyfe et al., Cytokine 2005 (Inflammation...) : Available data suggest that NF-kappaB activation is required for IL-8 gene expression
Zhang et al., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2002 : The induction of IL-8 gene expression by fluid shear stress is probably due to the activation of NF-kappa B
Jobin et al., J Immunol 1997 : IL-1beta stimulated NF-kappaB nuclear translocation and NF-kappaB dependent IL-1beta and IL-8 expression in both Caco-2 and HT-29 cells as assayed by electrophoretic mobility shift assay, immunofluorescence, kappaB-luciferase transfection, reverse transcriptase-PCR analysis and ELISA
Belt et al., Am J Obstet Gynecol 1999 : In this study we investigated the possible role of the nuclear transcription factor NF-kappaB in interleukin-1 signaling, leading to the expression of cyclooxygenase 2 and prostaglandin production in human myometrial cell cultures ... Stimulation of human myometrial cells with interleukin 1 leads to rapid activation of the transcription factor NF-kappaB , which is functionally linked to the expression of cyclooxygenase 2 messenger ribonucleic acid, protein, and prostaglandin synthesis
Li et al., Pulm Pharmacol Ther 2013 : EM, EM703 inhibit NF-kB activation induced by oxidative stress from diesel exhaust particle in human bronchial epithelial cells : Importance in IL-8 transcription
Carpenter et al., BMC infectious diseases 2002 (Lung Neoplasms) : In this study, we examined the NF-kappaB mediated effects of RSV and the proinflammatory cytokine TNFalpha on the induction of IL-8 , MCP-1 and RANTES chemokine gene expression in A549 epithelial cells
Feng et al., Mol Cell Biol 2005 : The LIM protein Ajuba influences interleukin-1 induced NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex
Son et al., FEBS Lett 2005 : Histidine also abolished the NF-kappaB dependent activation of the IL-8 promoter induced by TNF-alpha
Mahon et al., J Biol Chem 1995 (Lymphoma, T-Cell...) : The tyrosine kinase inhibitor herbimycin A was found to block NF-kappa B stimulation in response to interleukin-1 and phorbol 12-myristate 13-acetate in EL4.NOB-1 thymoma cells and phorbol 12-myristate 13-acetate in Jurkat T lymphoma cells
Komine et al., Mol Immunol 2007 (Periodontitis) : Con A low-affinity saliva Lf peptides, PR3 treated Lf preparation and two of four synthetic polypeptides induced the production of interleukin IL-6, monocyte chemoattractant protein-1 and IL-8, and the activation of NF-kappaB in human oral epithelial HSC-2 cells
Georganas et al., J Immunol 2000 (Arthritis, Rheumatoid) : Inhibition of NF-kappaB activation significantly reduced the spontaneous and IL-1beta induced secretion of IL-6 and IL-8 by RA FLS and the IL-1ss induced production of IL-6 and IL-8 by human dermal fibroblasts
Kim et al., Clin Exp Immunol 2001 : Polarized secretion of CXC chemokines by human intestinal epithelial cells in response to Bacteroides fragilis enterotoxin : NF-kappa B plays a major role in the regulation of IL-8 expression
Lai et al., J Ethnopharmacol 2008 (Gastritis) : Furthermore, H. pylori induced nuclear factor (NF)-kappaB activation, and the subsequent release of interleukin (IL)-8 in AGS cells were also inhibited by the extract PUC
Shimada et al., J Pharmacol Exp Ther 1999 : Because IL-8 expression is regulated by the transcription factor nuclear factor-kappaB (NF-kappaB) , we also examined the effect of polaprezinc on NF-kappaB activity
Munitz et al., Gastroenterology 2010 (Colitis...) : In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6, interleukin-1beta , and tumor necrosis factor alpha ) and activation of MAPK and NF-kappaB in Pirb-/- macrophages following bacterial activation
Sur et al., J Invest Dermatol 2008 : As synthesis of the pro-inflammatory cytokine IL-8 and the prostanoid PGE ( 2 ) are regulated by NF-kappaB , this could be a probable mechanism by which Hsp27 modulates the production of these inflammatory cytokines
Brat et al., Neuro Oncol 2005 (Brain Neoplasms...) : The potential tumor suppressor ING4 was recently shown to be a critical regulator of NF-kappaB mediated IL-8 transcription and subsequent angiogenesis in gliomas
Markovina et al., Molecular cancer 2010 (Multiple Myeloma) : Among the multiple factors evaluated, interleukin-8 was secreted by BMSCs from MM patients at significantly higher levels compared to those from non-MM sources, and we found that IL-8 contributes to BMSC induced NF-kappaB activity
Li et al., Molecular vision 2007 : Cultured limbal and conjunctival cells responded to stimulation by polyriboinosinic polyribocytidylic acid ( poly [ I:C ] ), palmitoyl-3-cysteine-serine-lysine-4 ( Pam3CSK ) and flagellin with increased secretion of IL-6 and IL-8 and the activation of NFkappaB
Vega-Ostertag et al., Arthritis Rheum 2005 : Our data show that aPL induces significant increases in TF transcription, function, and expression, in IL-6 and IL-8 up-regulation, and in iNOS expression on HUVECs and that these processes involve phosphorylation of p38 MAPK and activation of NF-kappaB
Chan et al., Cytokine 2006 (Cell Transformation, Viral) : In human bronchial epithelial cells, binding sites for NFkappaB , AP-1, and NF-IL6 in the 5'-flanking region of the IL-8 promoter are necessary for optimal NaCl induction of IL-8
Jang et al., Life Sci 2006 : In this study, the effects of scoparone on the expression of interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) and activation of nuclear factor-kappaB (NF-kappaB) were examined in U937 human monocytes activated with phorbol 12-myristate 13-acetate ( PMA )
Sheller et al., Exp Lung Res 2009 (Asthma...) : Accompanying the exaggerated inflammation was an increase in the cytokines granulocyte colony stimulating factor ( G-CSF ), interleukin (IL)-15, and KC. Interestingly, the counter regulatory interleukin , IL-10, was suppressed by NF-kappa B activation
Krasnow et al., Cytokine 1991 (Lymphoma, T-Cell) : Tumor necrosis factor-alpha, interleukin 1, and phorbol myristate acetate are independent activators of NF-kappa B which differentially activate T cells
Ivanov et al., Cell Signal 2010 : The NF-kappaB dependent gene expression of IL8 , IL6, PTGS2/COX2, TNF and IL33 in directly irradiated human skin fibroblasts produced the cytokines and prostaglandin E2 ( PGE2 ) with autocrine/paracrine functions, which further activated signaling pathways and induced NF-kappaB dependent gene expression in bystander cells
Wysoczynski et al., Int J Cancer 2010 (Anoxia...) : This suggests that IL-8 expression is regulated in an activating protein (AP)-1- and nuclear factor (NF)-kappaB dependent manner
Wang et al., Nat Immunol 2006 : Tumor necrosis factor receptor associated factor 6 ( TRAF6 ) is critical for mediating Toll-like receptor ( TLR ) -interleukin 1 receptor (IL-1R) signaling and subsequent activation of NF-kappaB and AP-1, transcriptional activators of innate immunity
Kim et al., Parasitol Res 2001 (Toxoplasmosis) : These results suggest that NF-kappaB is a central regulator of the chemokine response in T. gondii infected human epithelial cells and that chemokine IL-8 and MCP-1 secretion might be involved in the pathogenesis of T. gondii, via the recruitment of neutrophils, monocytes, and lymphocytes
Rundall et al., Surgery 2004 (Carcinoma, Non-Small-Cell Lung...) : NF-kappaB activity was determined by reporter-gene assays and by reverse transcriptase-polymerase chain reaction of the endogenous NF-kappaB dependent gene interleukin 8
Inagaki et al., J Biol Chem 2008 : Tumor necrosis factor- and interleukin-1 induced activation of TAK1 was entirely normal in Tab1-deficient MEFs and could activate both mitogen activated protein kinases and NF-kappaB
Zhao et al., J Biol Chem 2006 : We have demonstrated earlier that lysophosphatidic acid (LPA) induced interleukin-8 (IL-8) secretion is regulated by protein kinase Cdelta (PKCdelta) dependent NF-kappaB activation in human bronchial epithelial cells ( HBEpCs )
Harimaya et al., Int J Pediatr Otorhinolaryngol 2007 (Gram-Positive Bacterial Infections...) : We investigated the role of NF-kappaB and mitogen activated protein ( MAP ) kinases in chemokine interleukin-8 (IL-8) production by human peripheral blood mononuclear cells ( PBMCs ) after stimulation with A. otitidis ... And, inhibitors of NF-kappaB ( caffeic acid phenylethyl ester ), p38 ( SB 203580 ), or ERK1/2 ( PD 98059 ) significantly reduced IL-8 induction by the organism
Sadik et al., Int J Biochem Cell Biol 2008 (Lyme Disease) : Systematic analysis highlights the key role of TLR2/NF-kappaB/MAP kinase signaling for IL-8 induction by macrophage-like THP-1 cells under influence of Borrelia burgdorferi lysates
Jaspers et al., J Biol Chem 1999 : IL-8 expression is regulated at the transcriptional level in part by the transcription factor nuclear factor (NF)-kappaB
Ye et al., Biochem Biophys Res Commun 2009 (Inflammation) : ROS and NF-kappaB are involved in upregulation of IL-8 in A549 cells exposed to multi walled carbon nanotubes
Im et al., Am J Physiol Gastrointest Liver Physiol 2009 (Colitis, Ulcerative) : B.P. CM also increased NF-kappaB activation, and inhibitors of NF-kappaB suppressed B.P. CM-induced tube formation and IL-8 production
Kang et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2008 : These results suggest that HSP22 induces IL-8 in VSMCs via ERK1/2, and that transcription factor NF-kB may be required for the HSP22 induced IL-8 up-regulation
Béraud et al., Proc Natl Acad Sci U S A 1999 : The compound had virtually no effect on tumor necrosis factor- and interleukin-1 induced NF-kappaB activities
Nanua et al., Am J Respir Cell Mol Biol 2006 : Quercetin also inhibited TNF-alpha induced PI 3-kinase activity, Akt phosphorylation, intracellular H ( 2 ) O ( 2 ) production, NF-kappaB transactivation , IL-8 promoter activity, and steady-state mRNA levels, consistent with the notion that quercetin inhibits chemokine expression by attenuating NF-kappaB transactivation via a PI 3-kinase/Akt dependent pathway
Sadowska et al., Pharmacol Res 2006 : Neutrophils from healthy volunteers ( NAC naïve ) were pre incubated with NAC for 30 min and the effects on the release of elastase and IL-8 , the respiratory burst in response to fMLP and PMA, on TNFalpha induced NFkappaB activation and on the migration across an endothelial-epithelial bilayer were investigated
Pati et al., J Virol 2001 (Sarcoma, Kaposi) : NF-kappaB activation was enhanced by the chemokine GROalpha, but not by IL-8
Kim et al., J Ethnopharmacol 2005 : Cheongyeolsaseuptang inhibits production of TNF-alpha, IL-6 and IL-8 as well as NF-kappa B activation in human mast cells
King et al., J Biol Chem 2009 : Thus, MKP-1 attenuates TNFalpha dependent activation of p38 MAPK, induction of IL-8 expression, and NF-kappaB dependent transcription
Bowie et al., J Biol Chem 1997 : Here we have investigated the effect of a range of putative antioxidants on NF-kappaB activation by interleukin-1 and tumor necrosis factor as well as the ability of H2O2 to activate NF-kappaB in primary human umbilical vein endothelial cells and the transformed human endothelial cell line ECV304
Kempuraj et al., Int Arch Allergy Immunol 2003 : Azelastine inhibits secretion of IL-6, TNF-alpha and IL-8 as well as NF-kappaB activation and intracellular calcium ion levels in normal human mast cells ... Azelastine inhibited hCBMC secretion of IL-6, TNF-alpha and IL-8 , possibly by inhibiting intracellular Ca2+ ions and NF-kappaB activation
Sakamoto et al., J Clin Endocrinol Metab 2003 (Endometriosis) : We hypothesize that TNFalpha may induce IL-8 production in endometriotic cells through nuclear factor-kappa B (NF-kappa B) activation ... These findings demonstrate that NF-kappa B activation is critical for TNFalpha induced IL-8 expression in endometriotic stromal cells
Wickremasinghe et al., J Immunol 1999 : Such IL-8 secretion is NF-kappa B dependent , NF-IL-6 requiring, and activated by an IL-1 mediated pathway as a consequence of phagocytosis of M. tuberculosis by monocytes
Takeuchi et al., PLoS Pathog 2013 : NF-?B is a transcriptional regulator that controls important aspects of innate immune responses, and NF-?B RelA/p65 homodimers regulate transcription of IL8
Iber et al., Arch Biochem Biophys 2000 : Suppression of CYP2C11 gene transcription by interleukin-1 mediated by NF-kappaB binding at the transcription start site
Fujioka et al., Clin Cancer Res 2003 (Neoplasm Metastasis...) : Inhibiting NFkappaB activation by expressing IkappaBalphaM and using pharmacologic NFkappaB inhibitor PS-341 also significantly reduced cytokine induced vascular endothelial growth factor and interleukin-8 expression in AsPc-1 pancreatic cancer cells
Im et al., Mol Immunol 2009 : Furthermore, NF-kappaB and NF-IL6 transcription factors played an important role in the flagellin induced IL-8 gene expression in A549 cells
Yu et al., J Immunol 2002 : However, ectopic expression of a mouse pellino-2 antisense construct inhibited IL-1 or LPS induced activation of NF-kappaB dependent IL-8 promoter activity
Ren et al., Laryngoscope 2004 (Carcinoma...) : LMP1 induces IL-8 mainly through the activation of NF-kappa B and partly through AP-1 in NPC model cell lines, NPC-KT, and this suggests that LMP1 plays an important role in the angiogenesis of NPC
Rajaram et al., J Immunol 2010 : The induced IL-8 response mediated by mannose capped lipoarabinomannan and the mannose receptor is independent of TLR2 and NF-kappaB activation
Ryu et al., Infect Immun 2004 (Trichomonas Vaginitis) : Furthermore, an NF-kappaB inhibitor ( pyrrolidine dithiocarbamate ), a mitogen activated protein ( MAP ) kinase ( MEK ) inhibitor ( PD98059 ), and a p38 MAP kinase inhibitor ( SB203580 ) significantly suppressed IL-8 synthesis in neutrophils
Purkerson et al., Eur J Immunol 2005 : The TRAF6, but not the TRAF2/3, binding domain was found to regulate IL-8 and IL-6 production, and induce activation of NF-kappaB and Jun kinase in lung fibroblasts, demonstrating for the first time that CD40ct domains can function independently to regulate pro-inflammatory responses of primary human fibroblasts
Chen et al., J Biomed Sci 2004 (MAP Kinase Signaling System) : A specific inhibitor of p38 MAPK ( SB203580 ) and an NF-kappaB inhibitor ( pyrrolidine dithiocarbamate ), but not an ERK inhibitor ( PD 98059 ), significantly inhibited neutrophil elastase induced IL-8 release and mRNA expression
Lerner et al., J Physiol Pharmacol 2009 : Inhibition of NF-kappaB with curcumin or parthenolide resulted in a decrease of IL-8 secretion
Yang et al., Cancer Res 2011 (Carcinoma, Squamous Cell...) : Depletion of RelA or dNp63 by small interfering RNA ( siRNA ) significantly inhibited NF-?B-specific, or TNF-a induced IL-8 reporter activation
Vilela et al., Int Immunopharmacol 2006 : As fenretinide is a ceramide up-regulating drug that inhibits the activation of the pro-inflammatory transcriptional factor, nuclear factor (NF)-kappaB, the impact of fenretinide on unstimulated and tumor necrosis factor (TNF)-alpha stimulated production of NF-kappaB dependent interleukin (IL)-8 was studied in immortalized wild-type ( non-CF ; 9HTEo- ) and mutant DeltaF508 CFTR ( CF ; CFTE29o- ) tracheal epithelial cells
Buchholz et al., Cell Microbiol 2006 : The AP-1, NFIL6 ( C/EBPbeta ) and NFkappaB transcriptional regulatory sites of the IL-8 promoter and the host NFkappaB signalling pathway were necessary for IL-8 induction by C. trachomatis
Ghadimi et al., Inflamm Bowel Dis 2010 : In response to apically applied natural commensal-origin DNA, polarized HT-29 and T84 cells enhanced expression of TLR9 in a specific manner, which was subsequently associated with attenuation of TNF-alpha induced NF-kappaB activation and NF-kappaB mediated IL-8 expression
Wright et al., Am J Physiol Heart Circ Physiol 2002 : However, interleukin-1beta and phorbol 12-myristate 13-acetate also activated NF-kappaB but did not evoke TNF-alpha expression, revealing that this factor is not sufficient for cytokine production
Soares et al., J Immunol 1998 : We report here that adenovirus mediated expression of a dominant negative C-terminal truncation mutant of p65/RelA ( p65RHD ) inhibits the induction of proinflammatory genes, such as E-selectin, ICAM-1, VCAM-1, IL-8 , and inducible nitric oxide synthase, in EC as efficiently as does I kappaB alpha
Powolny-Budnicka et al., Immunity 2011 (Bacterial Infections) : RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin dependent interleukin-17 production in ?d T cells
Akhtar et al., FASEB J 2003 (MAP Kinase Signaling System) : In contrast, inhibitors of NFkappaB activity ( PDTC, SN50 ) did not block E. coli DNA induced IL-8 production
Moreira et al., Invest Ophthalmol Vis Sci 2009 (Choroidal Neovascularization) : Inhibition of NF-kappaB with BAY 11-7082 reduced IL-8 but not VEGF induction
Kunsch et al., J Immunol 1994 : These data demonstrate that RelA and members of the C/EBP/NF-IL-6 family can functionally cooperate in transcriptional activation of the IL-8 gene and suggest a common mechanism for inducible regulation of cytokine gene expression
Chu et al., Dig Dis Sci 2003 (Helicobacter Infections...) : Role of NF-kappaB and AP-1 on Helicobater pylori induced IL-8 expression in AGS cells ... IL-8 may be regulated by oxidant-sensitive transcription factors, NF-kappaB , and AP-1 ... The present study aims to investigate whether H. pylori induced IL-8 expression is regulated by NF-kappaB and AP-1 in gastric epithelial AGS cells and whether this transcriptional regulation of IL-8 is inhibited by N-acetylcysteine (NAC)
Shishodia et al., J Biol Chem 2004 (Inflammation...) : Guggulsterone suppressed DNA binding of NF-kappaB induced by tumor necrosis factor (TNF), phorbol ester, okadaic acid, cigarette smoke condensate, hydrogen peroxide, and interleukin-1
Takizawa et al., Respirology 2000 (Inflammation...) : Transient transfection of airway epithelial cells with wild and NF-kappaB binding motifs indicated that the activation of NF-kappaB was essential for IL-8 gene upregulation by reporter gene assay
Sato et al., J Rheumatol 1996 (Arthritis, Rheumatoid) : Our data suggest that TNF-alpha induces expression of proinflammatory cytokines such as IL-8 and MCP-1 through generation of reactive oxygen intermediates and subsequent activation of NF-kappa B in human synovial cells, and the antioxidants may inhibit, at least in part, the activation of NF-kappa B by TNF-alpha
Zoja et al., Kidney Int 2002 (Hemolytic-Uremic Syndrome) : Shiga toxin-2 triggers endothelial leukocyte adhesion and transmigration via NF-kappaB dependent up-regulation of IL-8 and MCP-1
Mullan et al., Am J Respir Cell Mol Biol 2008 : beta-tryptase also up-regulated IL-8 mRNA expression, as analyzed by RT-PCR and real-time PCR, which was abolished by the transcription inhibitor actinomycin D. Reporter gene assay showed that beta-tryptase induced IL-8 transcription was mediated by the transcription factors activator protein-1, CCAAT/enhancer binding protein, and NF-kappaB , and chromatin immunoprecipitation assay demonstrated that beta-tryptase induced in vivo binding of these transcription factors to the IL-8 gene promoter
Escotte et al., Eur Respir J 2003 (Cystic Fibrosis) : To determine whether FP reduces cytokine production in bronchial epithelial cells via NF-kappaB, the authors investigated the nonstimulated and the Pseudomonas aeruginosa lipopolysaccharide (LPS) stimulated production of NF-kappaB dependent interleukin (IL)-6, IL-8 and RANTES ( regulated on activation, T-cell expressed and secreted ) along with the activation of NF-kappaB in non-CF and CF human bronchial gland epithelial cells
Sodin-Semrl et al., Int J Immunopathol Pharmacol 2004 (Arthritis, Rheumatoid) : A human IL-8 promoter luciferase construct was transfected into CHO cells stably expressing ALXR in order to determine the role of NF-kappaB and/or AP-1 in the regulation of IL-8 gene expression
Kang et al., Stem Cells Dev 2007 : On the basis of an IkappaB kinase (IKK) inhibitor study, expression of IL-8 induced by TNF-alpha was dependent on NF-kappaB activity
Jiang et al., J Biol Chem 2004 : Without ERK activation, interleukin-1beta induces only acute and transient NF-kappaB activation
Méndez-Samperio et al., Cell Immunol 2001 : Roles of intracellular calcium and NF-kappaB in the Bacillus Calmette-Guérin induced secretion of interleukin-8 from human monocytes
Finotti et al., Artif DNA PNA XNA 2012 (Cystic Fibrosis) : Since transcription factor NF-kappaB plays a critical role in IL-8 expression, the transcription factor decoy ( TFD ) strategy might be of interest
Lee et al., Helicobacter 2007 (Helicobacter Infections) : Nontoxic dose of capsaicin inhibited H. pylori induced IL-8 production by gastric epithelial cells through the modulation of IkappaB-, NF-kappaB- , and IL-8 pathways
Shibata et al., J Photochem Photobiol B 2009 (Arthritis, Rheumatoid...) : We also found that IL-1beta induced release of IL-8 from MH7A cells was completely blocked by pretreatment with the ( IL-8 ) inhibitor Bay11-7085, indicating that activation of NF-kappaB signaling plays an important role in the secretion of IL-8
Holtmann et al., J Biol Chem 2001 : Recently we found that coordinate activation of NF-kappaB and c-Jun N-terminal protein kinase (JNK) is required for strong IL-8 transcription, whereas the p38 MAP kinase ( MAPK ) pathway stabilizes the IL-8 mRNA
Cowburn et al., Eur J Immunol 2004 : These data suggest that cross-talk between NF-kappa B and PI3-kinase pathways in TNF-alpha -stimulated neutrophils results from NF-kappa B/ERK1/2 dependent IL-8 production which acts in an autocrine manner to drive PI3-kinase dependent survival
Li et al., J Immunol 2003 : In surviving cells, TRAIL activates NF-kappaB , induces expression of E-selectin, ICAM-1, and IL-8 , and promotes adhesion of leukocytes
Palanki , Curr Med Chem 2002 (Autoimmune Diseases) : In activated T cells, transcription factors such as the activator protein-1 (AP-1) regulate IL-2 production and production of matrix metalloproteinases, the nuclear factor kappa B (NF-kappa B) is essential for the transcriptional regulation of the proinflammatory cytokines IL-1, IL-6, IL-8 and TNF alpha, and nuclear factor of activated T-cells ( NFAT ) is required for the transcriptional regulation of IL-2, IL-3, IL-4, IL-5, IL-8 , IL-13, TNF alpha, and GM-CSF
Puthia et al., Eukaryotic cell 2008 (Blastocystis Infections) : Furthermore, we show that NF-kappaB activation is involved in the production of IL-8
Chen et al., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2001 : The induction of IL-8 gene expression by laminar shear stress is probably due to the activation of NF-kappa B
Li et al., Nan Fang Yi Ke Da Xue Xue Bao 2007 (Burns...) : Compared to that of the control group, activity of pulmonary NF-kappaB in burned rats was markedly increased within 1 PBH and kept increasing till 24 h. Expressions of pulmonary TNF alpha and IL-8 mRNAs increased gradually, reaching the peak level at 6 PBH, and PDTC could effectively inhibit pulmonary NF-kappaB activation and expression of the pulmonary cytokines induced by the burn injury
Schreck et al., EMBO J 1991 : NAC and other thiol compounds also blocked the activation of NF-kappa B by cycloheximide, double stranded RNA, calcium ionophore, TNF-alpha, active phorbol ester, interleukin-1 , lipopolysaccharide and lectin
Lee et al., Korean J Parasitol 2008 (Inflammation) : T. gondii lysate triggered nuclear factor (NF)-kappaB dependent IL-8 expression in HEK293 cells transfected with TLR2
Li et al., J Exp Med 1999 : Accordingly, IKKbeta-deficient cells are defective in activation of IKK and NF-kappaB in response to either tumor necrosis factor alpha or interleukin 1
Simeonova et al., Lab Invest 1999 : Furthermore using cell transfection and mobility shift assays, it was found that transcriptional activation of the IL-8 gene required TNF-alpha induced activation and binding of nuclear factor-kappaB (NF-kappaB)- and NF-IL-6, nuclear transcription factors to regulatory elements in the IL-8 promoter
Zhang et al., J Leukoc Biol 2005 : NF-kappaB mediated IL-8 release was independent of Pneumocystis phagocytosis
Ning et al., Respirology 2007 (Respiratory Distress Syndrome, Adult) : Role of Rel A and IkappaB of nuclear factor kappaB in the release of interleukin-8 by cyclic mechanical strain in human alveolar type II epithelial cells A549 ... This study aimed to determine whether stretch induced IL-8 production is dependent on degradation of IkappaB ( IkappaB ) and the resulting Rel A translocation into the nucleus ... Cyclic mechanical stretch can activate Rel A translocation and IkappaBalpha degradation, thus inducing the secretion of IL-8 in alveolar epithelial type II cells
Chen et al., J Vasc Res 2007 (Vasculitis) : Exposure to Ang II ( 10 ( -6 ) M for 24 h ) also enhanced intracellular ROS elaboration and the levels of tumor necrosis factor (TNF)-alpha and interleukin (IL)-8 , upregulated chemokine receptor CXCR2 mRNA expression, increased adhesion of endothelial cells to monocytes and induced a significant increase in the activity of nuclear factor (NF)-kappaB , which was attenuated by pretreatment with the Ang II receptor blocker losartan ( 1, 3 and 10 muM )
Harrison et al., Infect Immun 2008 : Vibrio cholerae flagellins induce Toll-like receptor 5-mediated interleukin-8 production through mitogen activated protein kinase and NF-kappaB activation ... Each purified recombinant V. cholerae flagellin induced IL-8 production in T84 intestinal epithelial cells and also induced nuclear factor kappa B (NF-kappaB) activation in HEK293T/TLR5 transfectants, which was blocked by cotransfection with a TLR5 dominant negative construct, demonstrating TLR5 specificity
Henness et al., Am J Physiol Lung Cell Mol Physiol 2006 (Lung Neoplasms) : As IL-17A had no effect on the activity of NF-kappaB , a key transcriptional regulator of IL-8 gene expression, we then examined whether IL-17A acts at the posttranscriptional level
Nowak et al., Mol Cell Biol 2008 : Here we find that phospho-Ser ( 276 ) RelA is required only for activation of IL-8 and Gro-beta, with IkappaBalpha being unaffected
Fiedler et al., Am J Physiol 1996 (Respiratory Syncytial Virus Infections) : Mutational analysis of the 200-bp 5'-untranslated region of the IL-8 gene demonstrated that activation of NF-kappa B and NF-IL-6 were required for RSV induced transcriptional activation of the IL-8 gene
Oh et al., Am J Chin Med 2009 : Furthermore, resveratrol inhibited extracellular signal regulated kinase ( ERK ) and p38 MAPK phosphorylation, IkappaBalpha degradation, NF-kappaB activation and cyclooxygenase (COX)-2 expression, which suggest that resveratrol inhibits IL-8 secretion by blocking MAPK phosphorylation and NF-kappaB activation
Wheeler et al., J Nutr 2004 : Because the gene expression of interleukin-8 (IL-8) , the major human neutrophil chemoattractant, is dependent on activation of NF-kappa B , IL-8 gene expression in human lung epithelial ( A549 ) cells treated with human IL-1 beta was used as a model of IL-1 beta signal transduction
Fowler et al., Biochem Cell Biol 1999 : Nitric oxide regulates interleukin-8 gene expression in activated endothelium by inhibiting NF-kappaB binding to DNA : effects on endothelial function
Higashihara et al., Redox Rep 2004 : These results suggest that NF-kappaB and PPAR-gamma regulate H/R stimulated IL-8 production in U937 cells
Coward et al., Clin Exp Allergy 2004 : The NF-kappaB inhibitors, calpain inhibitor 1 ( 10 microm ), pentoxifylline ( 0.5 mm ), pyrrolidine dithiocarbamate ( PDTC, 10 microm ) or gliotoxin ( 1 pg/mL ) reduced the generation of GM-CSF, TNF-alpha and IL-8 in parallel with their inhibition of NF-kappaB
de Mejia et al., Peptides 2009 (Inflammation) : The 5 kDa peptide inhibited most potently pro-inflammatory markers including interleukin-6 production ( IC ( 50 ) =2 microM ), interleukin-1beta production ( IC ( 50 ) =13 microM ), nuclear factor-kappa B (NF-kappaB) transactivation ( IC ( 50 ) =21 microM ), cyclooxygenase-2 expression ( IC ( 50 ) =25 microM ), nitric oxide production ( IC ( 50 ) =28 microM ), inducible nitric oxide synthase expression ( IC ( 50 ) =37 microM ), prostaglandin E ( 2 ) production ( IC ( 50 ) =41 microM ), p65 nuclear translocation ( IC ( 50 ) =48 microM ) and p50 nuclear translocation ( IC ( 50 ) =77 microM )
Garrouste et al., Cell Death Differ 2002 : Correspondingly, IGF-I markedly enhanced the TNF- and IFN/TNF induced NF-kappaB dependent interleukin-8 production
Kim et al., Cytokine 2005 : Involvement of mitogen activated protein kinase and NF-kappaB activation in Ca2+ induced IL-8 production in human mast cells ... NF-kappaB inhibitors blocked the ability of Ca ( 2+ ) to induce IL-8 production, and the activation of NF-kappaB was required for intracellular Ca ( 2+ ) -induced up-regulation of IL-8
Gobert et al., J Immunol 2007 : Consequently, the NF-kappaB dependent CCL20 and IL-8 gene transcription and chemokine production were enhanced in T84 cells infected with the Stx mutant in comparison to the wild-type strain
Alvarez et al., J Immunol 2006 (MAP Kinase Signaling System) : When analyzing the role of these pathways on neutrophil functions, we observed that up-regulation of CD11b triggered by bacterial DNA was decreased by pharmacological inhibitors of the p38 MAPK, ERK1/2, and JNK, whereas stimulation of IL-8 release was dependent on p38, ERK1/2, and NF-kappaB
Kim et al., Mol Immunol 2007 (Ovarian Neoplasms) : TNF-alpha induced IL-8 promoter activation that is inhibited by saxatilin treatment was dependent on activating protein-1 (AP-1) instead of nuclear factor-kappa B (NF-kappaB)
Hii et al., J Infect Dis 2008 : We showed that B. pseudomallei activates NF-kappaB via Toll-like receptor (TLR) 2, TLR4, and TLR5 but can also activate NF-kappaB and induce interleukin (IL)-8 without involving TLRs. TLR independent activation depends on a functional Bsa type III secretion system ( T3SS ) and requires internalization
Suzuki et al., Trends Immunol 2006 : Although each system seems to possess distinct activation mechanisms, interleukin-1 receptor associated kinase ( IRAK)-4 is essential for NF-kappaB activation in Toll-like receptor ( TLR ) and T-cell receptor ( TCR ) signaling pathways
Delgado et al., Infect Immun 2006 (Cystic Fibrosis...) : IL-8 secretion was not due to an increase in NF-kappaB- or activator protein-1 dependent IL-8 promoter transcription, but instead depended on p38 and Erk mitogen activated protein kinases
Qiu et al., J Biol Chem 1999 : In 16HBE human bronchial epithelial cells, IL-8 expression is regulated predominantly by NF-kappaB , and PG490 but not cyclosporin A can completely inhibit expression of IL-8
Heitmeier et al., J Biol Chem 1998 : Double stranded RNA induced inducible nitric-oxide synthase expression and interleukin-1 release by murine macrophages requires NF-kappaB activation
Foryst-Ludwig et al., Biochem Biophys Res Commun 2004 (Helicobacter Infections) : Here we report that H. pylori induced NF-kappaB activation and the subsequent release of interleukin 8 (IL-8) are inhibited by curcumin ( diferuloylmethane ), a yellow pigment in turmeric ( Curcuma longa L. )
Li et al., Molecular vision 2007 : Inhibition of NF-kappaB partially prevented the induction of IL-1alpha, IL-8 , and ELAM-1, but not IL-6
Sawai et al., Med Sci Monit 2005 (Pancreatic Neoplasms) : These results suggest that MAPK/AP-1 and ROS/NF-kappaB signaling pathways are involved in IL-1alpha induced IL-8 secretion and that these paracrine signaling pathways enhance endothelial cell proliferation
Oda et al., J Immunol 2002 : Although NF-kappaB is involved in regulating the IL-1alpha induced expression of MCP-1 and IL-8 , the degradation of IkappaB-alpha stimulated by IL-1alpha was not inhibited by alprazolam ... Alprazolam prevented NF-kappaB from binding to the MCP-1 promoter region ( the A2 and A1 oligonucleotide probes ), but binding of NF-kappaB to IL-8/NF-kappaB was not inhibited
Saatian et al., Biochem J 2006 : Furthermore, SB203580 attenuated LPA dependent phosphorylation of IkappaB ( inhibitory kappaB ), NF-kappaB and phospho-p38 translocation to the nucleus, NF-kappaB transcription and IL-8 promoter mediated luciferase reporter activity, without affecting the JNK pathway and AP-1 transcription
Li , J Pharmacol Sci 2003 (Bacterial Infections...) : Among those signaling pathways, activation of NF-kappaB leads to up-regulation of IL-1beta, IL-8 and TNF-alpha, mucin MUC2 and Toll-like receptor 2 (TLR2), whereas activation of p38 MAP kinase mediates not only up-regulation of inflammatory mediators and mucin MUC5AC but also down-regulation of TLR2
Choi et al., World J Gastroenterol 2006 : Although all three MAP kinase family members were phosphorylated in response to TNF-alpha, a selective inhibitor of p38 kinase SB203580 only could inhibit both NF-kappaB dependent transcriptional activity and IL-8 and CCL20 production, suggesting a potential link between p38 kinase and NF-kappaB dependent pathways in AGS cells
Tanaka et al., Biochem Biophys Res Commun 1997 (Astrocytoma) : Redox regulation of lipopolysaccharide (LPS) induced interleukin-8 (IL-8) gene expression mediated by NF kappa B and AP-1 in human astrocytoma U373 cells
Lee et al., Clin Exp Allergy 2007 (Asthma) : IL-8 promoter deletion analysis indicated that position -132 to +41 was essential for GCE induced IL-8 transcription, and mutants with substitutions in activator protein (AP)-1, nuclear factor (NF)-IL6 and NF-kappaB binding sites revealed a requirement for NF-kappaB and NF-IL6, but not AP-1, in GCE induced activation of the IL-8 promoter
Lim et al., Am J Physiol Gastrointest Liver Physiol 2009 : Through reporter gene studies, we show that poly ( I:C ) -induced NF-kappaB activation is critical for the transactivation of the IL-8 promoter in vitro and that nuclear translocation of NF-kappaB occurs at an early time point following poly ( I:C ) stimulation of esophageal epithelial cells
Ju et al., Ann N Y Acad Sci 2006 : Role of mitogen activated protein kinases, NF-kappaB , and AP-1 on cerulein induced IL-8 expression in pancreatic acinar cells
Karashima et al., Clin Cancer Res 2003 (Anoxia...) : Nuclear factor kappaB (NF-kappaB)/relA regulates IL-8 expression in several neoplasms ... The purpose of this study was to determine whether the organ microenvironment ( hypoxia, acidosis ) regulates the expression of IL-8 in TCC via NF-kappaB, and whether inhibition of NF-kappaB function by mutant IkappaB-alpha prevents induction of IL-8 expression ... The involvement of NF-kappaB and activator protein 1 in the regulation of IL-8 production was evaluated by electrophoretic mobility shift assay
Simone et al., PloS one 2011 : Lycopene inhibits NF-kB mediated IL-8 expression and changes redox and PPAR? signalling in cigarette smoke stimulated macrophages ... NF-kB controlled the transcription of IL-8 induced by CSE, since PDTC prevented such a production
Fichorova et al., J Infect Dis 2001 (HIV Infections...) : Analysis of molecular and cellular components in cervicovaginal secretions, as well as results from in vitro activation of cervicovaginal epithelial cells and U1/HIV promonocytic cells, showed that multiple N-9 use can promote HIV-1 transmission through interleukin-1 mediated NF-kappaB activation, which leads to chemokine induced recruitment of HIV-1 host cells and increased HIV-1 replication in infected cells
Manna et al., J Biol Chem 2005 : In this report we provide evidence that like TNF, an inducer of NF-kappaB and also a NF-kappaB dependent gene product, IL-8 induces NF-kappaB in a unique pathway ... IL-8 induces NF-kappaB activation in a dose dependent manner in different cell types as detected by a DNA-protein binding assay ... IL-8 induces NF-kappaB dependent reporter gene expression as well as ICAM-1, VCAM-1, and Cox-2 expression ... IL-8 induced NF-kappaB activation is for the most part unaltered when cells are transfected with dominant negative TRADD, FADD, or TRAF2, but is inhibited with dominant negative TRAF6-, NIK-, IKK-, or IkappaBalpha transfected cells ... The data suggest that IL-8 induced NF-kappaB activation proceeds through a TRAF2 independent but TRAF6 dependent pathway, followed by recruitment of IRAK and activation of IKK ... IL-8 induced NF-kappaB activation is not observed in a cell-permeable peptide that has TRAF6 binding motif treated cells or IRAK-deficient cells ... IL-8 induced NF-kappaB activation proceeds mostly through interaction with TRAF6 and partially through the Rho-GTPase pathways ... This is the first report that IL-8 induces NF-kappaB in a distinct pathway, and activation of NF-kappaB and its dependent genes may be one of the pathways of IL-8 induced inflammation and angiogenesis
Zwergal et al., J Immunol 2006 : Earlier experiments in TNF-tolerant cells display inhibition of NF-kappaB dependent IL-8 gene expression at the transcriptional level with potential involvement of C/EBPbeta
Dosch et al., Virus Res 2009 (Severe Acute Respiratory Syndrome) : An NF-kappaB inhibitor, TPCK ( N-Tosyl-L-Phenylalanine Chloromethyl Ketone ) could suppress IL-8 production and secretion in response to S protein in PBMC and THP-1 cells and in HCoV-229E virus infected PBMC
Takenaka et al., Microbiology 2004 (Inflammation) : These findings suggest that H. pylori HSP60 activates NF-kappaB and induces IL-8 production through TLR triggered pathways in gastric epithelial cells
Varro et al., Cancer Res 2004 (Neoplasm Invasiveness...) : The activation of NFkappaB was required for interleukin-8 and cyclooxygenase-2 activation but did not occur in cells responding to these paracrine mediators
Vitiello et al., Cytokine 2004 (MAP Kinase Signaling System) : Our results elucidate some of the molecular mechanisms by which AP-1 and NF-kappaB regulate IL-8 release and open new strategies for the design of specific molecules that will modulate IL-8 effects in various infectious diseases
Liacini et al., Matrix Biol 2002 (Osteoarthritis, Hip) : Inhibition of interleukin-1 stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes
Bernasconi et al., J Biol Chem 2005 : Moreover, NF-kappaB was not essential for virus replication but triggered the expression of proinflammatory cytokines in infected lung cells and was directly responsible for production of high levels of interleukin-8 , a chemokine associated with influenza induced inflammation and airway pathology
Karimi et al., Respir Res 2006 : In addition, NFkappaB-inhibitor blocked cigarette smoke induced IL-8 production
Mondal et al., Am J Respir Cell Mol Biol 2000 : However, neither NF-kappaB translocation nor IL-8 gene induction occurred in adhered or ROFA exposed AMs
Si et al., J Immunol 2004 (Acquired Immunodeficiency Syndrome) : Interestingly, although LPS induced IL-8/CXCL8 was dependent on NF-kappaB , the baseline or 15d-PGJ ( 2 ) -mediated IL-8/CXCL8 production was NF-kappaB independent
Khan et al., J Immunol 2010 : Conversely, stable overexpression of Sigirr diminished NF-kappaB mediated IL-8 responses to TLR ligands
Van Huffel et al., J Biol Chem 2001 : NF-kappaB activation induced by TNF and interleukin-1 is inhibited by overexpression of ABIN-2
Bosch et al., J Virol 2002 : We studied the transcriptional regulation of IL-8 in the ECV304 and 293T cell lines and found that the induction of IL-8 gene expression involved the activation of NF-kappa B ( P = 0.001 ) and, to a lesser extent, the activation of NFIL-6 in ECV304 cells only
Chang et al., J Dent Res 2005 : Consistently, both TNF and LPS rapidly induced the expression of the NF-kappaB dependent gene interleukin-8 (IL-8)
Yoshida et al., Invest Ophthalmol Vis Sci 1998 (Anoxia...) : Role of NF-kappaB mediated interleukin-8 expression in intraocular neovascularization
Xu et al., PloS one 2010 : Reduction of CFTR expression in AM resulted in increased secretion of IL-8, increased phosphorylation of NF-kappaB , a positive regulator of IL-8 expression, and decreased expression of IkappaB-alpha, the inhibitory protein of NF-kappaB activation
Tsuchiya et al., Laryngoscope 2007 : However, the PGPS induced IL-8 promoter activation in rodent middle ear epithelial cells required NF-kappaB and NF-IL6 but not AP-1
Vig et al., J Biol Chem 1999 : Modulation of tumor necrosis factor and interleukin-1 dependent NF-kappaB activity by mPLK/IRAK
Zhang et al., Wei Sheng Yan Jiu 2011 : To investigate the effects of NF-kappaB on the expression of IL-8 in human bronchial epithelial cells induced by cigarette smoke condensates ( CSC )
Blumberg et al., J Interferon Cytokine Res 2005 : Extensions of these findings revealed that the Ctx A subunit induces transcriptional activation of proinflammatory genes in addition to TNF-alpha ( interleukin-8 [ IL- 8 ], intracellular adhesion molecule-1 [ ICAM-1 ], and IL-6 ) and that such transactivation is mediated by the transcriptional regulator NF-kappaB
Bobrovnikova-Marjon et al., Cancer Res 2004 (Breast Neoplasms) : Blocking NFkappaB and AP-1 activation with curcumin as well as expression of dominant inhibitors, inhibitor of nuclear factor-kappaB ( IkappaB ) super repressor ( IkappaBM ), and a mutant form of c-Fos ( A-Fos ) demonstrated that the activation of NFkappaB and AP-1 transcription factors was necessary for the induction of IL-8 expression but dispensable for the induction of VEGF expression
Zhu et al., J Biol Chem 2003 : Transcriptional regulation of interleukin (IL)-8 by bradykinin in human airway smooth muscle cells involves prostanoid dependent activation of AP-1 and nuclear factor (NF)-IL-6 and prostanoid independent activation of NF-kappaB ... Transcriptional activation of the IL-8 promoter by BK involves the prostanoid independent activation of NF-kappaB , and prostanoid dependent activation of AP-1 and NF-IL-6 plays a key role in augmenting the response
Xie et al., Oncol Rep 2010 (Glioblastoma...) : Constitutive NF-kappaB activity regulates the expression of VEGF and IL-8 and tumor angiogenesis of human glioblastoma
Fritz et al., J Orthop Res 2005 (MAP Kinase Signaling System) : Chemokine IL-8 induction by particulate wear debris in osteoblasts is mediated by NF-kappaB ... Particulate wear debris induced NF-kappaB activation, the major transcriptional regulator of IL-8 and MCP-1 pro-inflammatory genes and, indeed, both IL-8 and MCP-1 chemokine gene expressions were upregulated in titanium particulate stimulated human osteoblasts
Chen et al., J Cell Biochem 2003 : Our results suggest that NF-kappaB activation in PIMs followed by phagocytizing lipopolysaccharide resulted in the up-regulation of TNF-alpha, IL-1beta, IL-6, IL-8 , and COX-2, which could be alleviated by dexamethasone
Medin et al., J Infect Dis 2006 (Dengue) : We studied the mechanisms of IL-8 induction, using luciferase reporter constructs, and the effect of pharmacological inhibitors of either IL-8 secretion or nuclear factor- kappa B (NF-kappa B) activation on IL-8 induction by dengue 2 virus ( DEN2V ) infection
Takamatsu et al., BMC microbiology 2010 (Legionnaires' Disease) : Inhibitors of NF-kappaB , p38 MAPK, and JNK blocked L. pneumophila induced IL-8 expression
Chaturvedi et al., J Biol Chem 1997 : As sanguinarine also inhibited NF-kappaB activation induced by interleukin-1 , phorbol ester, and okadaic acid but not that activated by hydrogen peroxide or ceramide, the pathway leading to NF-kappaB activation is likely different for different inducers