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PRKAR1B — RELA
Text-mined interactions from Literome
Chen et al., J Biol Chem 1999
:
The
PKA inhibitor, H8,
inhibited the
NF-kappaB activation induced by 6- or 12-h treatment with LPS but not that induced after 1, 3, or 24 h
Du et al., Cell Immunol 2000
:
Inhibition of PKC and
PKA activation
results in suppression of activation and translocation of
NF-kappaB
Zhang et al., Cell Immunol 2000
:
The results in this paper indicate that LPS induced
NF-kappa B binding activity was
independent of PKC,
PKA , ERK, and p38 MAPK, but was regulated by proteasome
Herring et al., Cell Signal 2001
(MAP Kinase Signaling System) :
Therefore, the objective of the present studies was to determine the
role of cAMP and
protein kinase A (PKA) in the CBN mediated inhibition of IL-2, CREB, and
NF-kappaB in PMA/Io activated thymocytes
Um et al., Oncogene 2001
:
Furthermore,
PKA inhibitor
suppressed markedly the constitutive and drug induced activities of
NF-kappaB and Ku in MDR cells and subsequently potentiated the cytotoxic activity of anticancer drugs
Bengoechea-Alonso et al., Nitric Oxide 2003
:
These observations are consistent with the inhibition caused by W-7, NMLA, H-89, and cyclosporin A on NF-kappaB induction by these agonists, indicating the
involvement of
PKA and PP2B in the regulation of
NF-kappaB in human monocytes
Takeuchi et al., J Neurochem 2003
(Neuroblastoma) :
Stimulation with forskolin and overexpression of constitutively active
PKA suppressed
NF-kappaB activity, likely due to D1R stimulation
Aizawa et al., Circ Res 2003
:
The effects of SNAP and CNP on
NF-kappaB are
mediated by cAMP dependent
protein kinase (PKA) but not cGMP dependent protein kinase ( PKG ) based on the findings that the selective PKA inhibitor, PKI, abolished the effects of SNAP and CNP on NF-kappaB, whereas the PKG inhibitor Rp-8-Br-PET-cGMP had no effect
Yu et al., J Mol Med (Berl) 2004
:
The activity of
NF-kappaB can be
regulated by
protein kinase A (PKA) in a cAMP independent manner
Boonyaratanakornkit et al., FASEB J 2005
:
Since
NF-kappaB , AP-1, and CREB are all
regulated by
PKA and are transcription factors predicted by microarray analysis to be involved in the altered gene expression in vectorless gravity, the data suggest that PKA is a key player in the loss of T-cell activation in altered gravity
Wei et al., Biochem Pharmacol 2007
(Adenocarcinoma...) :
Activation of ERK and p38 MAPK appeared to be mediated primarily by transactivation of EGFR, whereas activation of CREB and
NF-kappaB was
mediated by
PKA , PKC and ERK
Manna et al., Mol Immunol 2009
(Neoplasms) :
It
inhibited phosphorylation of
Rel A ( p65 ) by inhibiting activity of
protein kinase A (PKA)
Lee et al., Toxicology 2009
:
Taken together, these results suggest that
PKA dependent
NF-kappaB inhibition stimulates 15d-PGJ ( 2 ) -mediated mitochondrial apoptotic pathway through alterations in expression of the NF-kappaB target genes Bax
Hong et al., J Surg Res 2010
:
In this study, the
role of
PKA in mediating the effect of cAMP on
NF-kappaB was investigated ... Overexpression of
PKA increased IL-1beta plus IFNgamma induced
NF-kappaB binding ... These results suggest that
PKA is not
essential for the inhibitory effect of cAMP on
NF-kappaB binding activity in hepatocytes
Gao et al., J Biol Chem 2010
(Breast Neoplasms) :
In this study, we have demonstrated the
effect of
PKA on
NF-kappaB activity in view of AKIP1 action ; and in 293 and HeLa cells, where the endogenous AKIP1 expression is minimal, PKA activating agents inhibited the NF-kappaB dependent reporter gene expression, blocked the interaction of PKAc and p65 subunit of NF-kappaB, and attenuated PKA dependent phosphorylation of p65 on Ser-276
Ghosh et al., Nature 1990
(Second Messenger Systems) :
Using gel retardation assays we found that PKC, cyclic AMP dependent
protein kinase (PKA) and a haem regulated eIF-2 kinase ( HRI ) could
activate NF-kappa B in vitro, whereas casein kinase II was ineffective
Shirakawa et al., Mol Cell Biol 1989
:
In contrast,
PKA and PKC did not
activate NF-kappa B in nuclear extracts from unstimulated cells
Neumann et al., EMBO J 1995
:
These results indicate that
PKA mediated suppression of
NF-kappa B activity plays an important role in the control of activation of peripheral T lymphocytes
Muroi et al., Cell Signal 1993
:
LPS induced activation of
NF-kappa B was
inhibited by a
protein kinase A (PKA) inhibitor ( H-89 ), but not by a protein kinase C ( PKC ) inhibitor ( H-7 ) ... Thus, these data suggested a probable
involvement of
PKA in LPS induced
NF-kappa B activation in macrophages
Zhong et al., Mol Cell 1998
:
The transcriptional activity of
NF-kappa B is
stimulated upon phosphorylation of its p65 subunit on serine 276 by
protein kinase A (PKA) ... Therefore,
PKA regulates the transcriptional activity of
NF-kappa B by modulating its interaction with CBP/p300