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NFKB1 — RHO

Text-mined interactions from Literome

Reyes-Reyes et al., J Cell Sci 2001 (Leukemia) : In addition, a dominant negative form of Rho augmented NF-kappaB activation and blocked MAPK activation, implying that these two pathways are in competition with each other
Cammarano et al., J Biol Chem 2001 : Here we show that although Dbl activation of NF kappa B requires Cdc42, Rac, and Rho , the different GTPases activate NF kappa B by different mechanisms ... Whereas Rac stimulates the activity of the I kappa B kinase IKK beta, Cdc42 and Rho activate NF kappa B without activating either IKK alpha or IKK beta
Hippenstiel et al., Biochem Pharmacol 2002 : In order to analyze the role of Rho proteins in TNF-alpha induced NF-kappaB-activation in human umbilical cord vein endothelial cells ( HUVEC ) we used Clostridium difficile toxin B-10463 ( TcdB-10463 ) which inactivates RhoA/Rac1/Cdc42 by glucosylation and Clostridium botulinum C3-toxin which inhibits RhoA/B/C by ADP-ribosylation ... Blocking of Rho reduced NF-kappaB DNA binding as shown by electrophoretic mobility shift assays ... Therefore, TNF-alpha related Ikappa-B-degradation is Rho independent in HUVEC, whereas a Rho protein dependent signal is necessary to induce nuclear transport of NF-kappaB in these cells pointing to a novel and unique role of Rho in NF-kappaB-translocation
Grassl et al., Cell Microbiol 2003 (MAP Kinase Signaling System) : Using Clostridium difficile toxins that specifically inactivate small GTPases, and transfection of inhibitory proteins of the Rho-GTPases, we demonstrate that Rac1, but not Cdc42 or Rho , is required for activation of NF-kappaB by invasin
Liu et al., J Biomed Sci 2004 (Adenocarcinoma...) : We conclude that Rho/RTKN mediated NF-kappaB activation leading to cell survival may play a key role in gastric tumorigenesis
Liu et al., Oncogene 2004 : Rho/Rhotekin mediated NF-kappaB activation confers resistance to apoptosis
Morigi et al., Am J Pathol 2005 (Chronic Disease...) : These data suggest that reorganization of the actin cytoskeletal network in response to protein load is implicated in modulation of the ET-1 gene via Rho kinase dependent FAK activation of NF-kappaB and Ap-1 in differentiated podocytes
Wei et al., Mol Pharmacol 2006 : Further studies showed that LPS down-regulated Rho and ROCK activity, whereas IL-1beta increased them, suggesting a negative role of Rho and ROCK signaling, which is regulated in contrary manners by IL-1beta and LPS, in IKK/NF-kappaB activation
Iwasaki et al., Atherosclerosis 2008 (Hyperglycemia) : High glucose induces plasminogen activator inhibitor-1 expression through Rho/Rho-kinase mediated NF-kappaB activation in bovine aortic endothelial cells
Meyer-Schwesinger et al., American journal of physiology. Renal physiology 2009 (Nephritis...) : We therefore examined NF-kappaB signal transduction and found that NF-kappaB p65 phosphorylation and nuclear translocation were reduced by Rho kinase inhibition
Perona et al., Genes Dev 1997 : In contrast, activation of NF-kappaB by UV light was not affected by Rho , CDC42, or Rac-1 dominant negative mutants