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RLN1 — VEGFA

Text-mined interactions from Literome

Unemori et al., Hum Reprod 1999 (Menorrhagia...) : VEGF expression is temporally regulated in the endometrium, and our results suggest that relaxin , which is secreted by the corpus luteum and is present in the endometrium during the menstrual cycle and pregnancy, may be involved in regulating endometrial VEGF expression
Unemori et al., Wound Repair Regen 2000 (Disease Models, Animal...) : Because angiogenic wound cells are frequently macrophages, THP-1 cells, a cell line of monocyte lineage that binds relaxin specifically, were tested for and shown to induce vascular endothelial growth factor and basic fibroblast growth factor in response to relaxin
Koos et al., Ann N Y Acad Sci 2005 : New insight into the transcriptional regulation of vascular endothelial growth factor expression in the endometrium by estrogen and relaxin ... It is likely that studies now under way will also link relaxin induced VEGF expression to HIF-1
Dessauer et al., Ann N Y Acad Sci 2005 : Treatment of THP-1 or MMC cells with the PI3K inhibitor, LY294002, abolished the relaxin mediated stimulation of VEGF transcript levels
Jones et al., IDrugs 2001 : The results showed relaxin induced significantly more blood vessel growth at ischemic sites compared to animals treated with vehicle alone and, when administered systemically, it did not cause an increase in VEGF in non-wound cells
Morelli et al., Ann N Y Acad Sci 2009 (Endometriosis) : Since relaxin regulates the expression of MMPs and VEGF in the endometrium, we tested the hypothesis that relaxin plays a role in endometriosis by comparing the expression of relaxin mRNA and its LGR7 ( RXFP1 ) receptor mRNA in normal human endometrium to those in samples from patients with endometriosis
Figueiredo et al., Ann N Y Acad Sci 2009 : We confirm relaxin induced upregulation of vascular endothelial growth factor expression and regulation of M1/M2 cytokine profiles