Kim et al., J Immunol 2008
(Bacterial Infections...) :
Consistently, Nod2-null macrophages tolerant to LPS and MDP showed enhanced production of TNF-alpha and IL-6 as well as increased NF-kappaB and MAPK activation in response to the dipeptide KF1B , the Nod1 agonist
Shembade et al., EMBO J 2009
:
Furthermore, RNF11 was required for A20 to interact with and inactivate RIP1 to inhibit TNF mediated NF-kappaB activation