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Pathways - manually collected, often from reviews:
OpenBEL Selventa BEL large corpus:
RPS6KA4
→
MAPK1
(increases, MAPK1 Activity, RPS6KA4 Activity)
Evidence: several downstream substrates of ERK1/2 kinase have been identified (Brunet & Pouyssegur, 1997), including p90 ribosomal S6 kinase (p90rsk, also known as MAPK-activated protein kinase (MAPKAP-K) 1; Zhao et al. 1996) and mitogen- and stress-activated kinases (MSK) 1 and 2 (Deak et al. 1998).