Gene interactions and pathways from curated databases and text-mining

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MAPK15 — S100A12

Text-mined interactions from Literome

Kawase et al., J Periodontal Res 1999 : In addition, CGRP 's activation of MAPK stimulated its ability to phosphorylate the Elk-1 transcription factor
Durham et al., J Neurosci 2003 (Migraine Disorders) : Treatment with sumatriptan repressed NGF- and MAPK stimulated CGRP promoter activity
Hou et al., J Neurosci Res 2003 : The inhibitors of PKC, JNK MAPK and NF-kappaB, but not p38 or ERK1/2 MAPK , blocked IL-1beta induced CGRP release
Liu et al., Chin Med Sci J 2003 (Coronary Restenosis) : In addition, ET and AII attenuated the expression of HRG-1 in aorta and stimulated mitogen activated protein kinase ( MAPK ) activity, while CGRP and Adm potentiated the expression of HRG-1 and inhibited MAPK
Kawase et al., Am J Physiol Cell Physiol 2005 : CGRP acted as a significant agonist only upon ERK dephosphorylation, whereas this analog effectively antagonized CGRP induced cAMP production and phosphorylation of cAMP response element binding protein ( CREB ) and p38 MAPK ... Although it had no agonistic action when used alone, CGRP ( 8-37 ) potently blocked CGRP actions on cAMP, CREB, and p38 MAPK but had less of an effect on ERK
Park et al., J Biol Chem 2008 : These results demonstrate that USF1 and USF2 are important contributors to neuronal-specific and mitogen activated protein kinase regulation of the CGRP gene in trigeminal ganglion neurons
Park et al., Neuroscience 2010 : Inhibiting mitogen activated protein kinase ( MEK ) activity also blocks the ability of NGF to increase CGRP expression