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FOS — S100B
Text-mined interactions from Literome
Bianchi et al., Neurobiol Aging 2010
(Encephalitis...) :
We show here that : ( 1 )
S100B also stimulates AP-1 transcriptional activity in microglia via RAGE dependent activation of JNK ; ( 2 ) S100B upregulates IL-1beta and TNF-alpha expression in microglia via RAGE engagement ; and ( 3 ) S100B/RAGE induced upregulation of COX-2, IL-1beta and TNF-alpha expression
requires the concurrent activation of NF-kappaB and
AP-1
Bianchi et al., J Biol Chem 2011
(Encephalitis) :
The S100B/RAGE dependent activation of
diaphanous-1/Rac1/JNK/AP-1 , Ras/Rac1/NF-?B and Src/Ras/PI3K/RhoA/diaphanous-1 results in the up-regulation of expression of the chemokines, CCL3, CCL5, and CXCL12, whose release and activity are
required for
S100B to stimulate microglia migration