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AKT1 — S1PR1

Pathways - manually collected, often from reviews:

• WikiPathways Signal Transduction of S1P Receptor: AKT1/AKT2/AKT3 → S1PR1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: AKT1 — S1PR1 (in vivo) Lee et al., Mol Cell 2001*
• IRef Hprd Interaction: AKT1 — S1PR1 (in vitro) Lee et al., Mol Cell 2001*

Text-mined interactions from Literome

Waeber et al., Drug News Perspect 2004 : Finally, S1P also protects endothelial cells from apoptosis through activation of phosphatidylinositol 3-kinase/Akt/eNOS via S1P(1) and S1P(3) receptors
Lee et al., Histochem Cell Biol 2006 : In this report, we describe that S1P stimulated cortactin translocation to the cell periphery to form lamellipodia is specifically mediated by the endothelial S1P1 G-protein coupled receptor, and is regulated by G ( i ) -mediated Akt dependent S1P1 receptor phosphorylation and Cdc42/Rac activation pathways
Singleton et al., Circ Res 2009 (Disease Models, Animal...) : Silencing ( small interfering RNA ) Akt expression blocked OxPAPC mediated S1P(1) activation ( threonine phosphorylation ), whereas silencing S1P(1) receptor expression blocked OxPAPC mediated Tiam1 recruitment to CEMs, Rac1 activation, and EC barrier enhancement