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AKT3 — S1PR2

Text-mined interactions from Literome

Green et al., Nat Immunol 2011 : We found that antagonism of the kinase Akt mediated by S1P(2) and its downstream mediators Ga ( 12 ), Ga ( 13 ) and p115RhoGEF regulated cell viability and was required for growth control in chronically proliferating GCs
Takuwa et al., American journal of cancer research 2011 : S1PR2 could also mediate inhibition of Akt and cell proliferation/survival signaling via Rho-ROCK-PTEN pathway
Green et al., Immunol Rev 2012 : S1PR2 also dampens Akt activation and deficiency in S1PR2 or components of its signaling pathway result in a loss of growth control in chronically stimulated mucosal GCs
Beckham et al., Oncogenesis 2013 : Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling