Rentero et al., Cell Signal 2006
:
Although both pathways co-exist in cells, we showed that binding of HDL to scavenger receptor BI (SR-BI) in CHO cells activates Ras and MAPK in a PKC independent manner
Murao et al., Am J Physiol Endocrinol Metab 2008
(Atherosclerosis...) :
Expression of a constitutively active p38 MAPK inhibited SR-BI promoter activity in the presence or absence of glucose
Osada et al., J Biochem 2009
(MAP Kinase Signaling System) :
These results collectively suggested the following signalling pathway for the SR-BI induced phagocytosis : ( i ) PS-recognizing SR-BI activates associated GULP ; ( ii ) activated GULP induces MAPK phosphorylation ; ( iii ) activated MAPK increases GTP bound Rac1 ; and ( iv ) activated Rac1 induces a rearrangement of the actin cytoskeleton
Mulay et al., PloS one 2013
(MAP Kinase Signaling System) :
We recently demonstrated that the Ras/mitogen activated protein kinase ( MAPK ) signaling cascade regulates protein stability of Scavenger Receptor BI (SR-BI) through Proliferator Activator Receptor ( PPARa ) -dependent degradation pathways