Gene interactions and pathways from curated databases and text-mining

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IL1B — SETD2

Text-mined interactions from Literome

Hellwig-Bürgel et al., Blood 1999 (Anoxia...) : Since EPO gene expression is inhibited by the proinflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), while no such effect has been reported with respect to the VEGF gene, we investigated the effects of IL-1beta and TNF-alpha on the activation of the HIF-1 DNA binding complex and the amount of HIF-1alpha protein in human hepatoma cells in culture
Hellwig-Bürgel et al., Cell Physiol Biochem 2005 : HIF-1 is also activated by IL-1beta and may thus be involved in the stimulation of VEGF production by this cytokine
Zhang et al., J Neuroimmunol 2006 : Similarly, HIF-1 binding `` decoy '' oligonuleotide transfected into astrocytes inhibited both hypoxia induced transactivation of the HIF-1 reporter gene and IL-1beta secretion from transfected astrocytes
Kimura et al., Br J Pharmacol 2006 (Burns) : 3. In human keratinocyte cultures ( HaCaT cells ), ginsenoside Rb1 ( 100 fg ml(-1) to 1 ng ml(-1) ) enhanced VEGF production induced by IL-1beta and expression of hypoxia-inducible factor (HIF)-1alpha