Gene interactions and pathways from curated databases and text-mining

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CA2 — SFTPC

Text-mined interactions from Literome

Lyons et al., J Bone Miner Res 2001 (Calcium Signaling...) : Consistent with the coupling of Edg receptors to G proteins, SPP- and SPC induced Ca2+ signaling was inhibited by pretreatment of the cells with pertussis toxin ( PTx )
Mathieson et al., Br J Pharmacol 2006 : 3. In enzymatically dispersed cerebral artery myocytes, SPC increased [ Ca2+ ] i in a concentration dependent manner ( peak response at 10 microM : 0.4+/-0.02 ratio units ) as determined using the Ca2+ indicator, Fura 2 ... 5. In conclusion, S1P and SPC activate distinct MAP kinase isoforms and increase [ Ca2+ ] i via different mechanisms in rat cerebral artery
Hemmings et al., Naunyn Schmiedebergs Arch Pharmacol 2006 : As well, both S1P and SPC induce Ca2+-sensitization in vascular smooth muscle which is mediated through Rho kinase activation
Mulders et al., Auton Autacoid Pharmacol 2007 (Prostatic Neoplasms) : S1P and SPC increased intracellular Ca2+ levels, most likely in a receptor independent manner
Dettbarn et al., Brain Res 1995 : SPC induced CA2+ release differs from IP3 induced Ca2+ release in that it is more extensive in the cerebrum than in the cerebellum ... SPC induced Ca2+ release is inhibited by ryanodine receptor blockers but not by selective blockers of IP3 receptors
Ghosh et al., J Biol Chem 1994 : Sphingosine- but not SPC mediated Ca2+ release was blocked by 10 mM oxalate
Törnquist et al., Biochem J 1994 : In addition, the increase in [Ca2+ ] i in response to SPC , but not to SP, was attenuated in cells treated with phorbol myristate acetate or with the putative Ca ( 2+ ) -channel blocker SKF 96365, and in cells pretreated with pertussis toxin for 24 h. SPC did not activate the production of IP3 ... The results suggest that sphingosine derivatives are putative regulators of Ca2+ fluxes in FRTL-5 cells, and that SP and SPC may act on [Ca2+ ] i via different mechanisms
Yule et al., J Biol Chem 1993 : 1,4,5-IP3 but not SPC induced Ca2+ release was blocked by heparin, indicating that SPC induced Ca2+ release was not mediated through the IP3 receptor-channel complex
Betto et al., Biochem J 1997 : SPC causes a rise in diastolic Ca2+ , which is greatly reduced when the sarcoplasmic reticulum is depleted of Ca2+ by prior thapsigargin treatment
Chin et al., Am J Physiol 1998 : In cultured porcine aortic smooth muscle cells, sphingosylphosphorylcholine (SPC) , ATP, or bradykinin ( BK ) induced a rapid dose dependent increase in the cytosolic Ca2+ concentration ([Ca2+]i) and also stimulated inositol 1,4,5-trisphosphate ( IP3 ) generation ... Pretreatment of cells with pertussis toxin blocked the SPC induced IP3 generation and [Ca2+ ] i increase but had no effect on the action of ATP or BK
Gonda et al., Biochem J 1999 : In K562 cells stably expressing AGR16, S1P and sphingosylphosphorylcholine (SPC) dose-dependently increased [ Ca2+ ] i with half-maximal values of 3 nM and 100 nM respectively