Kessaris et al., Development 2004
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SHH activity also depends on mitogen activated protein kinase ( MAPK ) but SHH does not itself activate MAPK
Elia et al., Biochim Biophys Acta 2007
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Most importantly, we report that Shh induces MAPK/ERK and phosphoinositide 3-kinase (PI3K) dependent Akt phosphorylation and that activation of both signaling pathways is essential for Shh 's signaling in muscle cells
Atkinson et al., J Neurochem 2009
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Using this model we show for the first time that Shh pathway activation mediates rapid increases in p38 MAPK phosphorylation, without altering phosphorylation of either extracellular-signal regulated kinases or c-jun N-terminal kinases