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NFKB1 — SHH

Text-mined interactions from Literome

Schmidt-Ullrich et al., Development 2006 : We show that NF-kappaB activation is essential for induction of Shh and cyclin D1 expression and subsequent placode down growth
Nakashima et al., Cancer Res 2006 (Carcinoma, Pancreatic Ductal...) : We hypothesized that nuclear factor-kappaB (NF-kappaB) , a hallmark transcription factor in inflammatory responses, contributes to the overexpression of Shh in pancreatic cancer ... NF-kappaB induced Shh expression actually activated the Hh pathway in a ligand dependent manner and enhanced cell proliferation in pancreatic cancer cells
Heo et al., Stem Cells 2007 (Calcium Signaling...) : Subsequently, Shh increased the nuclear factor (NF)-kappaB p65 phosphorylation, which was inhibited by blocking PKC and EGFR tyrosine kinase
Kasperczyk et al., FASEB J 2009 (Neoplasms) : To explore mechanisms controlling sonic hedgehog (Shh) expression in human cancers, we investigated regulation of Shh by the transcription factor NF-kappaB ... Specific NF-kappaB inhibition by inhibitory NF-kappaBalpha ( Ikappa-Balpha ) superrepressor or p65 knockdown inhibits NF-kappaB induced Shh promoter activation and Shh expression ... NF-kappaB mediated Shh expression promotes proliferation and confers resistance to TRAIL induced apoptosis
Cui et al., Cancer Sci 2010 (Breast Neoplasms...) : Taken together, these observations suggest that Shh overexpression is a critical event in breast carcinogenesis, and Shh promoter hypomethylation and NF-kappaB up-regulation are responsible for the up-regulation of Shh