Gene interactions and pathways from curated databases and text-mining

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AKT3 — SLC22A3

Text-mined interactions from Literome

Cho et al., Biochem Biophys Res Commun 2007 : In this report, we suggest phosphatidylinositol 3-OH kinase (PI3K)/Akt signaling is also necessary for TGF-beta induced EMT in lens epithelial cells by showing that LY294002, an inhibitor of the p110 catalytic subunit of PI3K, blocked the expression of alpha-smooth muscle actin ( alpha-SMA ) and morphological changes
Ho et al., Mol Cancer Res 2012 (Carcinoma, Renal Cell...) : Inhibition of PI3K/AKT by LY294002 reactivated GSK-3ß and suppressed the TNF-a induced EMT of RCC cells
Han et al., PloS one 2012 (Breast Neoplasms...) : The inhibitors of PI3K-AKT and ERK1/2 pathways, LY294002 and U0126, both significantly suppressed EMT and CSC phenotype, indicating that AKT and ERK1/2 pathways are required for miR-21 mediating EMT and CSC phenotype