Nishiumi et al., Toxicological sciences : an official journal of the Society of Toxicology 2010
(Insulin Resistance) :
TCDD also stimulated the phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2 and c-Jun N-terminal kinase (JNK), and their inhibitors abrogated the TCDD induced downregulation of IRbeta, IRS1, and GLUT4 ; upregulation of TNF-alpha ; and activation of NF-kappaB Wei et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2010
(Diabetes, Gestational...) :
The inhibition of NF-kappaB activity can increase the expression of GLUT-4 in uterus of GDM rats, indicating that the occurrence of GDM in rats with uteru insulin resistance may be related with the intervention of NF-kappaB activity on the down regulation of the expression of GLUT-4