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CASP1 — SLPI

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Lahusen et al., Mol Carcinog 2003 : Alp caused early activation of both caspase-8 and -9, leading to cleavage of caspase-3 and poly ( ADP-ribose ) polymerase ( PARP ) ... Studies of mitochondrial membrane potential also demonstrated that Alp is able to disrupt mitochondrial potential in the presence of ZVAD, suggesting that the activation of caspase-9 by Alp follows mitochondrial perturbation ... In summary, these experiments suggest that Alp activates caspase-9 via mitochondrial perturbation
Mogi et al., J Biol Chem 2003 : Peptide inhibition of caspase activity led to a dramatic reduction in ALP activation and PTH induced production of cAMP in BMP-4 treated cells