Chen et al., J Biol Chem 2009
(MAP Kinase Signaling System) :
We subsequently discovered that SMG-1 kinase activity was activated by hypoxia, and depletion of SMG-1 up-regulated MAPK activity under low oxygen
Hwang et al., Biochem Pharmacol 2010
:
SMG-1 attenuated FMLP induced increase of cytosolic calcium concentration and phosphorylation of p38 MAPK , ERK, JNK, and AKT