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NOTCH2 — SMN1
Text-mined interactions from Literome
Noseda et al., Circ Res 2006
:
Here, we show that
Notch directly
regulates expression of the mesenchymal and smooth muscle cell marker
smooth muscle alpha-actin (SMA) in endothelial and vascular smooth muscle cells via activation of its major effector, CSL ...
Notch/CSL activation
induces SMA expression during endothelial-to-mesenchymal transformation, and Notch activation is required for expression of SMA in vascular smooth muscle cells ... CSL directly binds a conserved cis element in the SMA promoter, and this consensus sequence is required for
Notch mediated
SMA induction
Ono et al., J Cell Physiol 2007
(Fibrosis...) :
Overexpression of active
Notch2 inhibited TGF-beta1 induced expression of
alpha-SMA and collagen I. Interestingly, transient knockdown of Notch2 by siRNA in C2C12 myoblasts and primary cultured muscle derived progenitor cells resulted in differentiation into myofibroblastic cells expressing alpha-SMA and collagen I without TGF-beta1 treatment
Tang et al., Circ Res 2008
:
The
Notch intracellular domain ( NotchICD ) forms a complex with CBF-1 ( C-promoter binding factor-1 ) and directly
induces SMA expression
Zhang et al., Int J Biochem Cell Biol 2013
:
Moreover,
Notch stimulated expression of mature smooth muscle genes
SMA , MHC, SM22, and calponin, which define the physiologic phenotype of normal vascular smooth muscle, was inhibited by type IV collagen in A7R5 cells