Gene interactions and pathways from curated databases and text-mining

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NOTCH2 — SMN1

Text-mined interactions from Literome

Noseda et al., Circ Res 2006 : Here, we show that Notch directly regulates expression of the mesenchymal and smooth muscle cell marker smooth muscle alpha-actin (SMA) in endothelial and vascular smooth muscle cells via activation of its major effector, CSL ... Notch/CSL activation induces SMA expression during endothelial-to-mesenchymal transformation, and Notch activation is required for expression of SMA in vascular smooth muscle cells ... CSL directly binds a conserved cis element in the SMA promoter, and this consensus sequence is required for Notch mediated SMA induction
Ono et al., J Cell Physiol 2007 (Fibrosis...) : Overexpression of active Notch2 inhibited TGF-beta1 induced expression of alpha-SMA and collagen I. Interestingly, transient knockdown of Notch2 by siRNA in C2C12 myoblasts and primary cultured muscle derived progenitor cells resulted in differentiation into myofibroblastic cells expressing alpha-SMA and collagen I without TGF-beta1 treatment
Tang et al., Circ Res 2008 : The Notch intracellular domain ( NotchICD ) forms a complex with CBF-1 ( C-promoter binding factor-1 ) and directly induces SMA expression
Zhang et al., Int J Biochem Cell Biol 2013 : Moreover, Notch stimulated expression of mature smooth muscle genes SMA , MHC, SM22, and calponin, which define the physiologic phenotype of normal vascular smooth muscle, was inhibited by type IV collagen in A7R5 cells