UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

IL12A — SOCS1

Pathways - manually collected, often from reviews:

NCI Pathway Database IL12-mediated signaling events: SOCS1 (SOCS1) → IL12/IL12R/TYK2/JAK2/SOCS1 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SOCS1) (modification, collaborate)
Endo et al., Nature 1997
Evidence: physical interaction
NCI Pathway Database IL12-mediated signaling events: SOCS1 (SOCS1) → IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2) (modification, collaborate)
Endo et al., Nature 1997
Evidence: physical interaction
NCI Pathway Database IL12-mediated signaling events: IL12/IL12R/TYK2/JAK2/SOCS1 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SOCS1) → IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2) (modification, collaborate)
Endo et al., Nature 1997
Evidence: physical interaction

Text-mined interactions from Literome

Davey et al., Tissue Antigens 2006 : In addition, SOCS1 has a complex role in T cell activation, and studies have revealed significant roles for SOCS1 in the regulation of IL-4, IL-12 and IL-15 in vivo
Zhang et al., J Immunol 2011 (Hepatitis C, Chronic) : Conversely, silencing SOCS-1 expression using small interfering RNAs increased IL-12 expression and inhibited PD-1 upregulation