◀ Back to RELA
RELA — SOCS1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
SOCS1
—
RELA
(physical association, affinity chromatography technology)
Ryo et al., Mol Cell 2003
-
IRef Biogrid Interaction:
SOCS1
—
RELA
(direct interaction, pull down)
Maine et al., EMBO J 2007
-
IRef Biogrid Interaction:
SOCS1
—
RELA
(physical association, affinity chromatography technology)
Strebovsky et al., FASEB J 2011*
-
IRef Hprd Interaction:
RELA
—
SOCS1
(in vivo)
Ryo et al., Mol Cell 2003, Maine et al., EMBO J 2007
-
IRef Hprd Interaction:
RELA
—
SOCS1
(in vitro)
Ryo et al., Mol Cell 2003, Maine et al., EMBO J 2007
-
IRef Intact Interaction:
Complex of TCEB2-CUL2-SOCS1-RELA-RBX1-TCEB1
(association, pull down)
Nishi et al., FEBS Lett 2009
-
IRef Intact Interaction:
SOCS1
—
RELA
(physical association, pull down)
Maine et al., EMBO J 2007
Text-mined interactions from Literome
Chong et al., J Biol Chem 2002
(MAP Kinase Signaling System) :
A further analysis revealed that
SOCS-1 deficiency
results in augmented TNF signaling via the p38 mitogen activated protein kinase pathway but not
NFkappaB or c-Jun N-terminal kinase pathways
Wesemann et al., J Immunol 2002
:
Additionally, IFN-gamma induced TNF-alpha secretion, as well as STAT-1alpha and
NF-kappaB activation, are inhibited in the
presence of
SOCS-1
Kinjyo et al., Immunity 2002
:
LPS induced I-kappaB and p38 phosphorylation was upregulated in SOCS1 ( -/- ) macrophages, and forced expression of
SOCS1 suppressed LPS induced
NF-kappaB activation
Ohishi et al., J Immunol 2005
(Bone Resorption) :
These data suggest that both
SOCS1 and SOCS3
regulate osteoclastogenesis by blocking the inhibitory effect of inflammatory cytokines on receptor activator of the
NF-kappaB ligand mediated osteoclast differentiation signals
Dai et al., J Invest Dermatol 2006
:
However,
SOCS1 did not
affect NF-kappaB signaling
Prêle et al., J Immunol 2008
:
Analysis of the early signaling pathway downstream of TLR4 demonstrated that
SOCS1 had no regulatory effect on the activation or on the DNA binding capacity of
NFkappaB
Koelsche et al., Mol Immunol 2009
:
In contrast,
nuclear factor kappaB (NFkappaB) signaling was not
affected by
SOCS1 wt or mutants
Charoenthongtrakul et al., J Virol 2011
:
Human T cell leukemia virus type 1 Tax inhibits innate antiviral signaling via
NF-kappaB dependent induction of
SOCS1