Gene interactions and pathways from curated databases and text-mining

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AKT1 — SOCS3

Text-mined interactions from Literome

Florholmen et al., Diabetologia 2006 (Insulin Resistance) : Chronic LIF treatment induced insulin resistance, possibly mediated by altered expression of Socs3 and Slc2a4, and impaired insulin mediated phosphorylation of GSK-3 and Akt/PKB
Tortorella et al., J Gerontol A Biol Sci Med Sci 2006 : These results indicate that defective PI3-K/Akt/ERK1/2 activation, likely dependent on elevated SOCS1 and SOCS3 levels, may affect the GM-CSF capacity to delay neutrophil apoptosis in elderly persons