◀ Back to TNF

SOD1 — TNF

Text-mined interactions from Literome

Yamashita et al., J Exp Med 1999 (Myocardial Infarction...) : The production of reactive oxygen species and endogenous TNF-alpha and IL-1beta induced by exercise leads to the activation of Mn-SOD , which plays major roles in the acquisition of biphasic cardioprotection against ischemia/reperfusion injury in rats
Xu et al., DNA Cell Biol 1999 : An intronic NF-kappaB element is essential for induction of the human manganese superoxide dismutase gene by tumor necrosis factor-alpha and interleukin-1beta
Maehara et al., J Cell Biochem 2000 : A NF-kappaB p65 subunit is indispensable for activating manganese superoxide : dismutase gene transcription mediated by tumor necrosis factor-alpha ... Expression of the manganese superoxide dismutase ( Mn-SOD ) is induced by tumor necrosis factor-alpha (TNF-alpha) , interleukin-1 (IL-1), and lipopolysaccharide (LPS) ... This report describes the minimal promoter region of the Mn-SOD gene and investigates the cis acting elements and trans acting factors responsible for TNF-alpha induced Mn-SOD gene expression ... These results show that a NF-kappaB p65 subunit is mainly involved in the molecular mechanisms controlling TNF-alpha mediated Mn-SOD gene transcription
Liu et al., Free Radic Biol Med 2000 (Carcinoma, Squamous Cell...) : Oxygen free radicals mediate the induction of manganese superoxide dismutase gene expression by TNF-alpha
Strålin et al., Atherosclerosis 2000 : The Mn-SOD activity was strongly up-regulated by TNF-alpha and IL-1alpha and moderately by IFN-gamma
Yamashita et al., Br J Pharmacol 2000 (Myocardial Reperfusion Injury...) : We conclude that the induction and activation of Mn-SOD , mediated by TNF-alpha and IL-1beta after IP, plays an important role in the acquisition of late-phase cardioprotection against ischaemia/reperfusion injury in rats
Shibuya-Fujiwara et al., Life Sci 2001 : Liposome encapsulated superoxide dismutase suppresses liposome mediated augmentation of TNF-alpha production from peripheral blood leucocytes
Karube-Harada et al., Mol Hum Reprod 2001 : The present study was undertaken to investigate the effect of tumour necrosis factor-alpha (TNFalpha) on superoxide dismutase ( SOD ) expression in human endometrial stromal cells ( ESC ) and to determine whether there is a difference in responsiveness to TNFalpha between ESC and decidualized ESC ... TNFalpha increased manganese-SOD ( Mn-SOD ) mRNA level and Mn-SOD activity in a dose dependent manner in ESC ... TNFalpha had no effect on copper-zinc-SOD ( Cu, Zn-SOD ) expression in either type of cell ... Incubation of ESC with actinomycin D, an RNA synthesis inhibitor, blocked TNFalpha induced Mn-SOD mRNA expression, but cycloheximide, a protein synthesis inhibitor, had no effect ... H7, an inhibitor of protein kinase C ( PKC ), also inhibited TNFalpha stimulated Mn-SOD mRNA expression in both types of cells ... These findings suggest that TNFalpha induced Mn-SOD expression is regulated at the transcription level and mediated by PKC dependent phosphorylation and that de-novo protein synthesis is not required for the TNFalpha effect ... In summary, TNFalpha induces Mn-SOD expression in human ESC
Wang et al., Chin Med J (Engl) 2002 (Shock, Septic) : It enhanced plasma SOD activity [ ( 1037.2 +/- 112.8 ) NU/L vs LPS + saline ( 615.4 +/- 92.6 ) NU/L, P < 0.01 ], reduced the MDA content [ ( 5.2 +/- 1.1 ) micromol/L vs. LPS + saline ( 9.8 +/- 1.5 ) micromol/L, P < 0.01 ], and inhibited TNF(alpha) induced [ Ca ( 2+ ) ] ( i ) elevation
Sugino et al., J Clin Endocrinol Metab 2002 : Nuclear factor-kappa B is required for tumor necrosis factor-alpha induced manganese superoxide dismutase expression in human endometrial stromal cells ... We recently found that manganese superoxide dismutase ( Mn-SOD ) is up-regulated by TNF alpha at the transcription level in human endometrial stromal cells ( ESC ) and that TNF alpha induced Mn-SOD expression is mediated by protein kinase C ( PKC ) -dependent phosphorylation ... TNF alpha and TPA significantly increased Mn-SOD activities and Mn-SOD mRNA levels, and those effects were completely inhibited by MG132 and SN50
Guo et al., J Biol Chem 2003 : Role of the intronic enhancer in tumor necrosis factor mediated induction of manganous superoxide dismutase ... Two regulatory regions, the proximal promoter region ( PPR ), which is upstream from the transcription initiation site, and the TNF-responsive element (TNFRE) , which is inside intron 2, are responsible for Mn-SOD expression
Ono et al., Biochem Biophys Res Commun 1992 (Carcinoma, Hepatocellular...) : Induction of Mn-superoxide dismutase by tumor necrosis factor , interleukin-1 and interleukin-6 in human hepatoma cells ... Effects of Tumor Necrosis Factor (TNF) , Interleukin-1 (IL-1), Interleukin-6 (IL-6) and Interferon-gamma (IFN-gamma) on the expression of Mn-superoxide dismutase ( Mn-SOD ) protein were investigated in human hepatoma cells, Hu-H1, which revealed resistance to the cytotoxicity of TNF and IL-1
Pang et al., J Biol Chem 1992 (Carcinoma, Papillary...) : Tumor necrosis factor-alpha activates nuclear factor kappa B and induces manganous superoxide dismutase and phosphodiesterase mRNA in human papillary thyroid carcinoma cells
Heller et al., Cell 1992 : When transfected with the human p70 TNFR, HeLa p70 die within 24 hr. HeLa p70 cells also show reduced c-fos and manganous superoxide dismutase induction by TNF
Tada et al., Hokkaido Igaku Zasshi 1992 (Brain Neoplasms...) : TNF at a low dose ( 10 U/ml ) stimulated production of prostaglandin E2, Mn-superoxide dismutase , interleukin (IL)-6 and IL-8 by glioblastoma cells
Chang et al., Biochem Biophys Res Commun 1992 : Cell killing and induction of manganous superoxide dismutase by tumor necrosis factor-alpha is mediated by lipoxygenase metabolites of arachidonic acid ... Our data reveal that TNF induction of manganous superoxide dismutase ( MnSOD ) is also dependent upon lipoxygenase activity
Tarabin et al., Naunyn Schmiedebergs Arch Pharmacol 2004 : Indeed, TNFalpha stimulated mRNA accumulation of the anti-apoptotic superoxide dismutase 2 through NF-kappaB whereas 6-OHDA induced mRNA accumulation of the pro-apoptotic c-myc
Marklund et al., J Biol Chem 1992 : TNF-alpha , IL-1 alpha, and IFN-gamma stimulated the Mn-SOD activity, as previously known, and these responses were reduced by TGF-beta
Suzuki et al., Free Radic Res Commun 1992 (Myocardial Infarction) : These facts suggest that TNF-alpha secretion from the infarcted area resulted in the production of Mn-SOD and that the induced Mn-SOD was released from myocytes into serum through damaged membranes, resulting in the late elevation
Imoto et al., Diabetes 2006 (Carcinoma, Hepatocellular...) : Using reduced MitoTracker Red probe, we confirmed that TNF-alpha increased mitochondrial ROS production, which was suppressed by overexpression of either uncoupling protein-1 (UCP)-1 or manganese superoxide dismutase ( MnSOD )
Basuroy et al., Am J Physiol Cell Physiol 2006 : The TNF-alpha response was inhibited by superoxide dismutase and catalase suggesting apoptosis is oxidative stress related
Afonso et al., Free Radic Biol Med 2006 : A JNK inhibitor antagonized the negative effects of TNF-alpha on SOD1 promoter activity, suggesting that JNK signaling through c-Jun protein activation is critical for the TNF-alpha dependent SOD1 repression ... A greater understanding of the mechanisms of TNF-alpha induced SOD1 repression could facilitate the design and development of novel therapeutic drugs for inflammatory conditions
Son et al., American journal of physiology. Renal physiology 2008 (Disease Models, Animal...) : Our in vitro studies utilizing cultured tubular cells revealed a role of TNF-alpha in downregulation of Cu/Zn-SOD
Xiao et al., Wei Sheng Yan Jiu 2008 (Obesity...) : ( 2 ) Serum SOD and GR activity decreased, and TNF-alpha level increased with body mass index ( BMI ) and abdominal fat mass, as shown by linear correlation analysis
Hu et al., J Ethnopharmacol 2008 (Drug-Induced Liver Injury) : Pretreatment with CGX significantly restored the reduction of catalase activity and glutathione ( GSH ) content, but not superoxide dismutase ( SOD ) activity, and it inhibited the CCl ( 4 ) -induced high expression of iNOS and TNF-alpha in hepatic tissue
Harris et al., J Immunol 1991 : Mn-SOD is induced by IFN-gamma and also by TNF in all four human cell lines examined : HS153 fibroblasts, ACHN renal carcinoma, A549 lung carcinoma, and A375 melanoma
Brauer et al., Neoplasia (New York, N.Y.) 2010 (Neovascularization, Pathologic) : Short interfering RNA ( siRNA ) -mediated knockdown of one of the photoaffinity labeled proteins, superoxide dismutase 1 , an ROS scavenger, resulted in an increase in tumor necrosis factor-alpha production by RAW 264.7 cells in response to DMXAA compared with negative or positive controls transfected with nontargeting or lamin A/C targeting siRNA molecules, respectively
Chertoff et al., Exp Neurol 2011 (Chronic Disease...) : Protective effects of low TNF-a level could be mediated by TNF-R1, GDNF, and IGF-1 in the SN and SOD activity in the striatum ( ST )
Zhang et al., World J Gastroenterol 2011 (Reperfusion Injury) : In group PHC, the tissue DAO and SOD activity at T2-T6, and IL-10 at T2-T5 increased to higher levels than those in group LIR ( P < 0.05 ) ; however, the levels of MPO, endotoxin, and DAO in the blood at T2-T6, and TNF-a at T2 and T4 decreased ( P < 0.05 )
Kawaguchi et al., Biochem Biophys Res Commun 1990 (Adenocarcinoma...) : Stimulation of Mn-superoxide dismutase expression by tumor necrosis factor-alpha : quantitative determination of Mn-SOD protein levels in TNF-resistant and sensitive cells by ELISA
Tsan et al., Am J Physiol 1990 : Molecular basis for tumor necrosis factor induced increase in pulmonary superoxide dismutase activities
Zhu et al., Nan Fang Yi Ke Da Xue Xue Bao 2012 (Acute Lung Injury) : Compared with those in LPS group, IL-1ß, IL-6, TNF-a and MDA in BALF, W/D, lung injury scores and iNOS mRNA and protein expression were significantly reduced and SOD in the BALF significantly increased in LPS+DAS group
Grdina et al., Radiat Res 2013 (Genomic Instability) : Utilizing these end points, RKO human colon carcinoma and transformed mouse embryo fibroblasts (MEF), wild-type or knockout cells missing TNF receptors 1 and 2 ( TNFR1 ( - ) R2 ( - ) ), and C57BL/6 and TNFR1 ( - ) R2 ( - ) knockout mice, we demonstrate that intact TNF signaling is required for induction of elevated manganese superoxide dismutase ( SOD2 ) activity ( P < 0.001 ) and the subsequent expression of these SOD2 mediated adaptive responses when cells are challenged at a later time with 2 Gy
Kong et al., Lipids in health and disease 2013 : However, comparing to the model rabbits, levels of TNF-a , IL-1ß and MDA decreased significantly and serum SOD activity increased , gene and protein expressions of E-sel, ICAM-1, VCAM-1 and MCP-1 in aortas decreased significantly with the treatment of kaempferol
Asoh et al., Biochem Biophys Res Commun 1989 (Breast Neoplasms) : Induction of manganese superoxide dismutase by tumor necrosis factor in human breast cancer MCF-7 cell line and its TNF-resistant variant ... TNF induced more mitochondrial manganese SOD ( SODm ) in MCF-7 than in Tnf-1000 whereas there appeared to be no significant induction of cytosolic copper/zinc SOD ( SODc ) by TNF in both MCF-7 and Tnf-1000 cell lines
Wong et al., Science 1988 : Induction of manganous superoxide dismutase by tumor necrosis factor : possible protective mechanism
Das et al., Mol Cell Biochem 1995 (Adenocarcinoma...) : TNF alpha and IL-1 each can activate NF-kappa B and induce gene expression of manganese superoxide dismutase ( MnSOD ), a mitochondrial matrix enzyme which can provide critical protection against hyperoxic lung injury
Perera et al., Arch Biochem Biophys 1995 (Carcinoma, Hepatocellular...) : Differential regulation of manganese superoxide dismutase activity by alcohol and TNF in human hepatoma cells
Wong et al., Biochim Biophys Acta 1995 : TNF or LT can specifically and selectively induce the expression of manganous superoxide dismutase ( MnSOD )
Nelson et al., J Mol Cell Cardiol 1995 (Myocardial Ischemia...) : Leukemia inhibitory factor and tumor necrosis factor induce manganese superoxide dismutase and protect rabbit hearts from reperfusion injury
Lin et al., Lymphokine Cytokine Res 1993 (Breast Neoplasms) : Cytotoxicity and manganese superoxide dismutase induction by tumor necrosis factor-alpha and ionizing radiation in MCF-7 human breast carcinoma cells
Niwa et al., Am J Pathol 1993 : Both manganese SOD and copper, zinc SOD activities were significantly induced by paraquat, interleukin-1, tumor necrosis factor , adriamycin, and bleomycin in lymphocytes and neutrophils from asymptomatic non aged adults, whereas neither activity was induced in aged individuals
Nakata et al., Int J Cancer 1993 : These data suggest that, in vivo, the TNF alpha and IL-1 alpha produced by cancer cells and other cells may induce Mn-SOD in vascular endothelial cells as well as other host tissues, resulting in release of a relatively large amount of this protein into the serum
Hirose et al., FASEB J 1993 (Melanoma) : Interleukin-1 (IL-1) and tumor necrosis factor (TNF) selectively induce mitochondrial manganese superoxide dismutase ( MnSOD ) production in various cell types
Nakata et al., Nihon Sanka Fujinka Gakkai Zasshi 1995 (Neoplasms) : These data suggest that in vivo the TNF-alpha produced by cancer cells may induce Mn-SOD in vascular endothelial cells, resulting in release of a relatively large amount of this protein into the serum
Pietarinen-Runtti et al., Cell Biol Toxicol 1996 : We compared induction of manganese superoxide dismutase ( MnSOD ) by asbestos fibers and tumor necrosis factor alpha (TNF) using cultured human mesothelial cells
Liu et al., J Formos Med Assoc 1996 (Gingival Hyperplasia) : To determine whether lipopolysaccharide (LPS) and tumor necrosis factor-alpha (TNF-alpha) are involved in the induction of superoxide dismutase ( SOD ) in gingival tissue, we examined their effect on induction of SOD isozymes in cultured normal ( NGF ) and phenytoin induced hyperplastic ( PHF ) gingival fibroblasts
Polla et al., Free radical research 1996 : Furthermore, SOD was inducible by TNF alpha in L929 cells, but not in L929.12 cells
Antras-Ferry et al., FEBS Lett 1997 : IL-1beta and TNF-alpha both stimulated specifically Mn-SOD gene expression in a time dependent manner ... TNF-alpha rapidly induced Mn-SOD gene expression while IL-1beta was a strong but slow inducer of this gene ... These results suggest that IL-1beta and TNF-alpha regulate Mn-SOD gene transcription by different pathways
Mattson et al., Neurosci Biobehav Rev 1997 (Cerebrovascular Disorders) : For example : basic fibroblast growth factor suppresses expression of a glutamate receptor protein and induces antioxidant enzymes ; tumor necrosis factor induces expression of a Ca ( 2+ ) -binding protein and Mn-superoxide dismutase ; and secreted forms of beta-amyloid precursor protein hyperpolarize neurons by activating K+ channels
Sasaki et al., Photochem Photobiol 1997 : Interleukin-1 alpha and TNF-alpha enhanced both the SOD activity and protein level of Mn SOD, while these cytokines had no effect on Cu-Zn SOD protein levels in cultured human keratinocytes after incubation for 24 h
Shibuya et al., Hepatology 1997 (Liver Diseases...) : After 24 hours of preservation, superoxide generation was inhibited in the control livers by anti-TNF antiserum, whereas TNF release was not inhibited by superoxide dismutase
Liochev et al., Free Radic Biol Med 1997 : The manganese containing mitochondrial superoxide dismutase ( MnSOD ) is induced by TNF and protects against the necrotic effect of this cytokine
Kettritz et al., J Am Soc Nephrol 1997 : No upregulation of endogenous manganese superoxide dismutase mRNA expression was observed in response to TNF alpha as measured by reverse transcription PCR
Arai et al., Biochem J 1998 (Second Messenger Systems) : TNF-alpha upregulation of endothelial-cell ICAM-1 expression was inhibited by the cell-permeable antioxidants, or by the adenovirus mediated intracellular overexpression of Cu, Zn-superoxide dismutase , but not by the exogenous ( extracellular ) administration of the cell-impermeable antioxidants, superoxide dismutase and/or catalase
Takahashi et al., J Dermatol Sci 1998 : Using SV40 transformed human keratinocytes ( SVHK cells ), we investigated the effects of anti-Fas antibody and TNF-alpha on the SOD activity ... The induction of IFN-gamma dependent Mn-SOD activity by anti-Fas antibody or TNF-alpha was concentration dependent ; the maximal effect was observed at 1-10 micrograms/ml and 5-10 ng/ml, respectively ... These results indicate that the stimulation of Fas antigen or TNF receptor increases Mn-SOD activity of SVHK cells in the presence of IFN-gamma and that TPA augments the process through the activation of protein kinase C