Rosewicz et al., Neuroendocrinology 2004
:
In parallel to growth inhibition, we observed a profound inhibition of VEGF gene transcription by IFN-alpha in human neuroendocrine tumor cells due to an Sp1/Sp3 dependent inhibition of VEGF promoter activity
Pagès et al., J Cell Physiol 2007
(MAP Kinase Signaling System) :
Sp3 mediated VEGF regulation is dependent on phosphorylation by extra-cellular signals regulated kinases ( Erk )
Finkenzeller et al., Oncogene 1997
:
Our data strongly suggest that enhanced VEGF gene expression in PDGF induced NIH3T3 cells is mediated by Sp1 and/or Sp3 transcription factors bound to the -85 to -50 promoter region of the VEGF gene