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IL6 — SPP1

Text-mined interactions from Literome

Koguchi et al., Infect Immun 2002 (AIDS-Related Opportunistic Infections) : Penicillium marneffei causes osteopontin mediated production of interleukin-12 by peripheral blood mononuclear cells
Himeno et al., J Bone Miner Res 2002 (Ossification, Heterotopic) : In primary culture of Cbfa1-/- chondrocytes, transforming growth factor (TGF) beta1, platelet derived growth factor ( PDGF ), interleukin (IL)-1beta , and thyroid hormone ( T3 ) induced osteopontin and MMP-13 expression
Cho et al., Calcif Tissue Int 2007 (Inflammation) : The mRNA expression of COL1A1 and osteopontin were not changed by IL-6 or its blocking antibody, but the alkaline phosphatase activities of MC3T3-E1 cells were increased by IL-6 and decreased by its blocking antibody
Mas et al., Mult Scler 2007 (Genetic Predisposition to Disease...) : OPN enhances the production of the pro-inflammatory cytokines, interleukin-12 and interferon-gamma, while reducing interleukin-10 levels
Take et al., Arthritis Rheum 2009 (Arthritis, Rheumatoid...) : In cocultures of FLS and B lymphocytes, the effects of OPN on adhesion of B lymphocytes to FLS and the consequent production of interleukin-6 (IL-6) were analyzed in experiments involving overexpression and knockdown of OPN and inhibitory studies with an OPN blocking antibody ... Moreover, OPN overexpression enhanced production of IL-6 in 75-kd OPN positive FLS-B lymphocyte cocultures
Samuvel et al., J Biol Chem 2010 : In our studies to explore the underlying mechanism, we found that the neutralizing antibodies against interleukin (IL)-6 or IL-6 small interfering RNA transfection in adipocytes effectively inhibited coculture stimulated osteopontin expression, suggesting that IL-6 released by adipocytes plays an essential role in the coculture stimulated osteopontin expression by U937 cells
Diao et al., Scand J Infect Dis 2011 (Streptococcal Infections) : We also found that OPN production was suppressed by interleukin-6 and enhanced by tumour necrosis factor-alpha in immunocompetent cells
Pini et al., J Leukoc Biol 2012 (Inflammation...) : In DIO mice, production of OPN and TIMP-1 was increased for a prolonged period, and this was mediated by IL-6 in the liver but not the pancreas
Diao et al., Cytokine 2012 (Drug-Induced Liver Injury...) : Osteopontin regulates interleukin-17 production in hepatitis
Singh et al., J Biol Chem 1995 : In vitro, interleukin-1 beta and interferon-gamma increased osteopontin mRNA levels in CMEC as well as NOS2 expression in both CMEC and cardiac myocytes
Kozawa et al., FEBS Lett 1997 : In the present study, we further investigated the mechanism of IL-6 synthesis induced by SPP in MC3T3-E1 cells ... PD98059, an inhibitor of MAP kinase kinase, suppressed SPP induced IL-6 synthesis as well as SPP induced MAP kinase activation ... TMB-8, an inhibitor of Ca2+ mobilization from intracellular Ca2+ stores, significantly suppressed the SPP induced IL-6 synthesis ... These results strongly suggest that SPP induced IL-6 synthesis is mediated via p42/p44 MAP kinase activation in osteoblast-like cells and that the SPP induced IL-6 synthesis is dependent on intracellular Ca2+ mobilization
Matsumoto et al., Int Immunol 1998 (Leukemia, Monocytic, Acute) : Inducible expression of nuclear factor IL-6 increases endogenous gene expression of macrophage inflammatory protein-1 alpha, osteopontin and CD14 in a monocytic leukemia cell line ... We demonstrated that inducible expression of NF-IL6 is able to increase endogenous gene expression of macrophage inflammatory protein (MIP)-1 alpha, osteopontin and CD14 in M1 cells