◀ Back to AKT1
AKT1 — SPRY2
Text-mined interactions from Literome
Lito et al., J Biol Chem 2009
:
In agreement with these findings, overexpression of
Spry2 in the parental non transformed fibroblasts
led to increased
Akt activation and to the stabilization of HDM2
Lee et al., Hepatology 2010
(Carcinoma, Hepatocellular...) :
In HCC cell lines,
Spry2 overexpression
inhibits c-Met induced cell proliferation as well as ERK and
AKT activation, whereas loss of Spry2 potentiates c-Met signaling
Patel et al., J Clin Invest 2013
(Cell Transformation, Neoplastic...) :
Here, we show that
SPRY2 deficiency alone
triggers activation of
AKT and ERK, but this is insufficient to drive tumorigenesis
Zhu et al., Dev Biol 2013
:
The pattern of
SPRY2 expression, and thus of
Akt activation and branch initiation, was controlled by mechanical signaling from endogenous cytoskeletal contractility