Gene interactions and pathways from curated databases and text-mining

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PPP2R1A — SRC

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Colello et al., J Cell Sci 2010 : Androgen and Src signaling regulate centrosome activity
Hu et al., BMC neuroscience 2009 (Brain Ischemia...) : Ischemia induced Src activation is followed by phosphorylation of PP2A at Tyr307 leading to its inhibition in the rat hippocampus
Xiong et al., Neurobiol Aging 2013 (Tauopathies) : Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A ( tyrosine 307 ) phosphorylation
Nho et al., J Biol Chem 2011 : The inhibition of Src activity dramatically increases PP2A and 4EBP-1 expression
Yokoyama et al., FEBS Lett 2001 : Addition of okadaic acid, a PP2A phosphatase inhibitor, abolished the PP2A dependent inhibition of v-Src ... These results imply that PP2A activity is essential for inhibition of v-Src
Switzer et al., Mol Cancer Res 2012 : NO, at physiologically relevant concentrations, induced an EGFR/Src mediated activation of oncogenic signal transduction pathways ( including c-Myc, Akt, and ß-catenin ) and the loss of PP2A tumor suppressor activity
Gupta et al., Biochem Biophys Res Commun 1994 : We report here that expression of the catalytic subunit of PP2A upregulates v-Src- and v-HaRas induced TRE mediated gene expression, whereas PP2A downregulates v-Src- and v-HaRas induced SRE mediated gene expression