◀ Back to SP1
SP1 — SREBF1
Pathways - manually collected, often from reviews:
-
FastForward regulation:
SP1
→
SREBF1
(transcriptional regulation, unknown)
Evidence: DNABINDING
-
Reactome Reaction:
SP1
→
SREBF1
(indirect_complex)
Xiong et al., Proc Natl Acad Sci U S A 2000*, Amemiya-Kudo et al., J Lipid Res 2002*, Oh et al., J Biol Chem 2003*, Shin et al., J Nutr 2007, Rome et al., Physiol Genomics 2008, Reed et al., PLoS Genet 2008, Choi et al., J Biol Chem 2008*, Bennett et al., J Biol Chem 1995*, Inoue et al., J Biochem 1998, Pai et al., J Biol Chem 1998
-
Reactome Reaction:
SP1
→
SREBF1
(reaction)
Xiong et al., Proc Natl Acad Sci U S A 2000*, Amemiya-Kudo et al., J Lipid Res 2002*, Oh et al., J Biol Chem 2003*, Shin et al., J Nutr 2007, Rome et al., Physiol Genomics 2008, Reed et al., PLoS Genet 2008, Choi et al., J Biol Chem 2008*, Bennett et al., J Biol Chem 1995*, Inoue et al., J Biochem 1998, Pai et al., J Biol Chem 1998
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Deng et al., J Biol Chem 2007
:
These studies identify a novel mechanism by which maximal activation of the rat
SREBP-1c gene expression by insulin is
mediated by
Sp1 and its enhanced ability to interact with other transcriptional regulatory proteins
Damiano et al., Biochem J 2009
:
Our data show that PUFA inhibition of hepatic Cic gene transcription is mediated not only by the nuclear level of
SREBP-1c , but also might
involve a reduction in
Sp1 and NF-Y DNA binding, suggesting differential mechanisms in the Cic gene regulation by different PUFA
Yamamoto et al., J Lipid Res 2010
(Diabetes Mellitus, Experimental) :
Knockdown of Sp proteins demonstrated that Sp3 and
Sp1 play reciprocally negative and positive roles in nutritional regulation of
SREBP-1c , respectively
Deng et al., J Biol Chem 2012
:
CA-FoxO1
inhibited SREBP-1c by reducing the transactivational capacity of both
Sp1 and SREBP-1c