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JUN — STAR
Text-mined interactions from Literome
Manna et al., Mol Endocrinol 2004
:
Assessment of the
role of
activator protein-1 on transcription of the mouse
steroidogenic acute regulatory protein gene ... The integrity of the sequence-specific AP-1 element in StAR gene transcription was assessed using the AP-1 family members, Fos ( c-Fos, Fra-1, Fra-2, and Fos B ) and Jun ( c-Jun, Jun B, and Jun D ), which demonstrated the
involvement of Fos and
Jun in
StAR gene transcription to varying degrees
Manna et al., Mol Endocrinol 2006
:
Conversely,
StAR gene transcription was markedly
inhibited by expression of nonphosphorylatable CREB ( Ser ( 133 ) Ala ), dominant negative A-CREB, and dominant negative
c-Jun ( TAM-67 ) mutants
Manna et al., Endocrinology 2011
:
Further studies pointed out that the regulatory events effected by PKD are associated with cAMP response element binding protein ( CREB ) and
c-Jun/c-Fos mediated transcription of the
StAR gene