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NFKB1 — STS

Text-mined interactions from Literome

Manji et al., J Biol Chem 2002 : When expressed in cells, ASC recruits PYPAF1 to distinct cytoplasmic loci and induces the activation of NF-kappaB ... Furthermore, coexpression of PYPAF1 with ASC results in a potent synergistic activation of NF-kappaB ... These findings suggest that PYPAF1 and ASC function as upstream activators of NF-kappaB signaling
Feng et al., Am J Physiol Gastrointest Liver Physiol 2002 (Necrosis) : STS activated I kappa B kinase and nuclear factor-kappa B (NF-kappa B) nuclear translocation and DNA binding but inhibited transactivation of I kappa B-alpha, inducible nitric oxide synthase, and inhibitor of apoptosis protein-1 in hepatocytes and NF-kappa B reporter in transfected Huh-7 cells
Grenier et al., FEBS Lett 2002 : Co-expression of PYPAF5 with ASC results in a synergistic activation of NF-kappaB and the recruitment of PYPAF5 to punctate structures in the cytoplasm
Stehlik et al., J Exp Med 2002 : While coexpression of ASC with certain PAAD-family proteins such as Pyrin and Cryopyrin increases NF-kappaB activity, ASC has an inhibitory influence on NF-kappaB activation by various proinflammatory stimuli, including tumor necrosis factor (TNF)alpha, interleukin 1beta, and lipopolysaccharide (LPS)
Dowds et al., Biochem Biophys Res Commun 2003 (Familial Mediterranean Fever) : Notably, pyrin, the product of the familial Mediterranean fever gene, inhibited cryopyrin mediated apoptosis and NF-kappaB activation by disrupting the cryopyrin-ASC interaction
Stehlik et al., Biochem J 2003 : In gene transfer experiments, POP1/ASC2 suppressed cytokine mediated NF-kappa B activation similar to other PAAD-family proteins previously tested
Hasegawa et al., J Biol Chem 2005 (Inflammation) : ASC mediated NF-kappaB activation leading to interleukin-8 production requires caspase-8 and is inhibited by CLARP ... The catalytic activity of caspase-8 was required for the ASC mediated NF-kappaB activation when caspase-8 was expressed at an endogenous level, although it was not essential when caspase-8 was overexpressed ... These results are the first to indicate that caspase-8 plays an important role in the ASC mediated NF-kappaB activation, and that the ASC mediated NF-kappaB activation actually induces physiologically relevant gene expression
Saito et al., Arthritis Rheum 2005 (Chronic Disease...) : In addition, the Y570C mutation ( with or without the S196N polymorphism ) increased the ability of CIAS1 to induce ASC dependent NF-kappaB activation, unlike the wild-type gene or the gene bearing the S196N polymorphism alone ... The production of interleukin-1beta (IL-1beta) by peripheral blood mononuclear cells ( PBMCs ) was measured by enzyme linked immunosorbent assay, and the ability of the mutant CIAS1 gene to enhance ASC dependent NF-kappaB activation was assessed to confirm that the mutations of CIAS1 found were responsible for the patient 's clinical manifestations of the CINCA syndrome
Sarkar et al., J Immunol 2006 : This RIP2 induced NF-kappaB activity and caspase-1 binding was inhibited in a dose dependent fashion by ASC
Kinoshita et al., Int Immunol 2006 : When co-expressed in HEK293 cells, FAF1 interfere with the NF-kappaB activation induced by PYPAF1 and ASC
Hasegawa et al., J Immunol 2009 : Although the role of ASC in caspase-1 mediated IL-1beta and IL-18 maturation is well known, ASC also induces NF-kappaB activation and cytokine gene expression in human cells
Imamura et al., J Immunol 2010 (Shock, Septic) : Interestingly, the NOD of human PYNOD was sufficient to inhibit caspase-1 mediated IL-1beta secretion, whereas its pyrin domain was sufficient to inhibit ASC mediated NF-kappaB activation and apoptosis and to reduce ASC 's ability to promote caspase-1 mediated IL-1beta production