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SYK — VEGFA
Text-mined interactions from Literome
Chakraborty et al., J Biol Chem 2006
(Anoxia...) :
Moreover,
Syk and Lck play differential roles in regulating Sp1 activation and expressions of melanoma cell adhesion molecule (MelCAM), urokinase-type plasminogen activator ( uPA ), matrix metalloproteinase-9 (MMP-9), and vascular endothelial growth factor ( VEGF ) in response to H/R. Overexpression of wild type Syk
inhibited the H/R induced uPA, MMP-9, and
VEGF expression but up-regulated MelCAM expression
Fruchon et al., Leukemia 2012
(Lymphoma, Follicular...) :
Moreover, using Syk small interfering RNA and the Syk inhibitor R406, we demonstrate that, in FL cells,
Syk is
involved in the regulation of MMP-9 and
VEGF expression, and that invasion and angiogenesis is mediated through a phosphatidylinositol-3 kinase (PI3K)-mammalian target of rapamycin module
Wang et al., J Pharmacol Exp Ther 2012
(Asthma) :
Further investigation of potential regulatory mechanisms revealed that inhibition of
Syk suppressed HRV induced
vascular endothelial growth factor expression while promoting the activation of caspase-3, a mediator of epithelial cell apoptosis